Growth of functional cranial components in rats with intrauterine growth retardation after treatment with growth hormone

Quintero, Fabián Aníbal; Castro, Luís; Luna, María Eugenia; Guimarey, Luis Manuel; Cesani, María Florencia; Fucini, María Cecilia; Villanueva, Myriam; Prio, Verónica; Oyhenart, Evelia Edith

doi:10.1093/ejo/cjr101

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…The time point of ossification has interspecific and interindividual variation 16,31 . Thyroid 32 and sexual hormone status 33 , as well as duration of general skeletal growth 34 have a major influence on the individual postnatal ossification of the synchondroses. Skull base synchondroses of both peke-face and doll-face Persians ossified between 12 and 14 months, while the synchondroses of the DSHs ossified much later (18-29 months).…”

Section: Discussionmentioning

confidence: 99%

Closure times of neurocranial sutures and synchondroses in Persian compared to Domestic Shorthair cats

Schmidt

Farke

Staszyk

et al. 2022

Sci Rep

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Human-directed selective breeding has modified the phenotype of the modern Persian cat towards an extreme brachycephalic phenotype (‘peke-face’ Persian), which originates from a spontaneous mutation that first appeared in the 1950s in traditional Persian types. It was suggested that the peke-face phenotype results from pathologic skull development and might represent a craniosynostosis of the coronal sutures. We followed this hypothesis and investigated the time dependent status of the neurocranial sutures and synchondroses in an ontogenetic series of doll-faced and peke-faced Persian cats compared to Domestic Shorthair cats (DSHs). Cranial suture closure was assessed by examining an ontogenetic series of formalin-fixed head specimens (n = 55) and dry skulls (n = 32) using micro-computed tomography. Sagittal, metopic, coronal and lambdoid sutures as well as intersphenoidal, spheno-occipital and spheno-ethmoid synchondroses were examined. Logistic regression analysis was performed to test the global effect of age on suture closure within a group of peke-face Persians, doll-face Persians and DSHs and the 50% probability of having a closed suture was calculated and compared between groups. Age was a perfect predictor for the condition of the coronal sutures in peke-face Persians. Coronal sutures were found to be closed at 0–0.3 months. In doll-face and DSHs, coronal sutures were open throughout the lifetime with the exception of a few very old cats. Results of this study confirmed a coronal craniosynostosis that likely causes the extreme brachycephalic skull morphology in the peke-face Persian.

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Section: Discussionmentioning

confidence: 99%

Closure times of neurocranial sutures and synchondroses in Persian compared to Domestic Shorthair cats

Schmidt

Farke

Staszyk

et al. 2022

Sci Rep

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“…Algunos de los resultados obtenidos a partir de estos estudios mostraron cambios ocurridos a nivel morfológico, tales como reducción del peso y tamaño corporal al nacimiento, retardo del crecimiento y efecto alométrico en los huesos del cráneo y del esqueleto postcraneano y modificación de los patrones de dimorfismo sexual, entre otros (Oyhenart et al, 1998(Oyhenart et al, , 1999(Oyhenart et al, , 2003a. Fueron varios los autores que acompañaron a Oyhenart en la realización de estos estudios (Dressino et al, 2002;Guimarey et al, 2003;Cesani et al, 2009;Quintero et al 2005Quintero et al , 2012Gonzalez et al, 2011a, b;Luna et al, 2014). Como parte de esta línea de investigación surgió el interés por analizar la acción de la hormona de crecimiento GH y su relación con las hormonas sexuales (andrógenos y estró-genos) frente al RPC y su eventual recuperación (Guimarey et al 2003Oyhenart et al 2008;Quintero, 2008;Quintero et al 2004Quintero et al , 2005Quintero et al , 2012, así como el efecto de la reducción del flujo sanguíneo materno-fetal seguido de subnutrición proteico calórica postnatal sobre el crecimiento ponderal, craneano y de órganos y tejidos funcionalmente asociados al segmento cefálico (Luna, 2012;Luna et al, 2014).…”

Section: Historia Del Empleo Del Método Experimental En Antropología unclassified

The experimental method in Biological Anthropology. History and current status in Argentina

Oyhenart¹,

Cesani²

2016

rev arg antrop biol

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RESUMEN La práctica experimental en Antropología no difiere en esencia de la de otras ciencias. Consiste en reproducir, bajo condiciones controladas, un hecho natural previamente observado, con el objetivo de estudiar su causa y efecto. Cuando se considera al hombre inmerso en un ambiente bio-físico-sociocultural, se torna dificultoso establecer patrones de diferenciación debido a la multiplicidad de factores actuantes y sus probables interacciones. En este contexto, surgió la necesidad de incorporar la metodología experimental en los estudios antropológicos. En el presente trabajo se realiza una revisión histórica y actual del em-PALABRAS CLAVE antropología biológica; método experimental; Argentina pleo del método experimental en Antropología Biológica. Se destacan los trabajos pioneros de Sherwood Washburn y Samuel Detwiler, realizados en anfibios, y los de Melvin Moss, en ratas, para estudiar el crecimiento craneano, entre otros. En Argentina, en particular, se reconoce a Héctor Pucciarelli como el responsable de incorporar dicha metodología en los estudios bioantropológicos en la década de los años 70 y de consolidar un grupo de trabajo y distintas líneas de investigación que continúan su desarrollo en la actualidad. Rev Arg Antrop Biol 18(1), 2016 doi:10.17139/ raab.2016.0018.01.07 KEY WORDS biological anthropology; experimental method; ArgentinaABSTRACT Experimental methods in Anthropology are not different from those of other sciences. They are used to simulate previously observed natural events under controlled conditions, in order to study their causes and effects. Given that humans are immersed in a biological, physical and socio-cultural environment, establishing differentiation patterns proves more difficult because of the multiplicity of factors involved and their probable interactions. In this context, it became necessary to incorporate the experimental method in anthropological studies.In our study we review the past and present of the experimental method in Biological Anthropology, namely, the pioneering work of Sherwood Washburn and Samuel Detwiler, in amphibians, and that of Melvin Moss, in rats, to study cranial growth. In Argentina, Héctor Pucciarelli is recognized as the first to introduce this methodology in bioanthropological studies in the seventies. He also consolidated a work group and developed different lines of research still in progress today. Rev Arg Antrop Biol 18(1), 2016 doi:10.17139/raab.2016.0018.01.07 Historia del empleo del método experimental en Antropología BiológicaUno de los principales temas de interés de la Antropología Biológica es el conocimiento del origen y variación del hombre, que si bien data de la antigüedad comienza a ser explíci-to, en la literatura, en el siglo XVIII. Ese fue también el momento en que se formalizó el concepto de "raza" y se propusieron diversos sistemas de clasificación (Little y Sussman, 2010). Fue el taxónomo sueco Carl von Linné (también conocido como Linneo) (1707-1778) quien identificó por primera vez la estrecha relación entre humanos ...

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“…So, the skull of all vertebrates is not a single developing unit but a complex structure that comprises recognizable parts that are coherent according to their developmental origin, structure, and function. These parts can be thought of as modules in the sense that they are highly integrated by numerous and usually strong interactions, while the interactions among them are relatively weaker [13,14,15].…”

Section: Introductionmentioning

confidence: 99%

Craniofacial catch-up growth in intrauterine growth retarded rats following postnatal nutritional rehabilitation

Me¹,

Fa²,

Cesani³

et al. 2014

Clin. Exp. Obstet. Gynecol.

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The aim of the study was to analyze the effect of postnatal nutritional rehabilitation on the craniofacial growth in rats with intrauterine growth retardation (IUGR). Materials and Methods: Wistar rats were assigned to one of the following groups: control, Sham-operated, and IUGR. The IUGR was produced by uterine vessels bending (day 14 of pregnancy). At days 1, 21, 42, 63, and 84 of postnatal life, each animal was X-rayed, and neural and facial length, width and height were measured. Volumetric and morphometric indices were calculated. Results: The decreased maternal-fetal blood flow during the last-third of the gestation period modified cranial size and shape of both sexes at birth. Discussion: Postnatal nutritional rehabilitation is not fully sufficient to reverse the prenatal growth retardation. There are specific responses depending on the sex and the age of the IUGR pups. Regardless of the changes in size, the shape is not modified during all the postnatal period.

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Growth of functional cranial components in rats with intrauterine growth retardation after treatment with growth hormone

Cited by 4 publications

References 37 publications

Closure times of neurocranial sutures and synchondroses in Persian compared to Domestic Shorthair cats

Closure times of neurocranial sutures and synchondroses in Persian compared to Domestic Shorthair cats

The experimental method in Biological Anthropology. History and current status in Argentina

Craniofacial catch-up growth in intrauterine growth retarded rats following postnatal nutritional rehabilitation

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