Growth of hamsters during continual centrifugation

Briney, Stanley R.; Wunder, Charles C.

doi:10.1152/ajplegacy.1962.202.3.461

Cited by 18 publications

(6 citation statements)

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“…Hypergravity hamsters weighed less than hamsters conceived and born in normal gravity (HL and HS hamsters vs. CON and ROT hamsters), which is in accordance with earlier studies concerning the effect of hypergravity on body weight in rodents [3,22]. Rotation in the centre of the centrifuge (ROT group) did not result in a body weight decrease, a finding also reported by Martin [18].…”

Section: Discussionsupporting

confidence: 91%

Altered Behaviour in Hamsters Conceived and Born in Hypergravity

Sondag

Jong

Oosterveld

1997

Brain Research Bulletin

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Section: Discussionsupporting

confidence: 91%

Altered Behaviour in Hamsters Conceived and Born in Hypergravity

Sondag

Jong

Oosterveld

1997

Brain Research Bulletin

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“…Body mass loss has been previously observed in centrifuging studies using chickens (Smith et al 1959), mice (Wunder 1960), hamsters (Briney and Wunder 1962) and rats (Oyama and Platt 1965). It has been suggested that major cause of loss of body mass could be the decreased amount of fatty tissue in the presence of muscle hypertrophy (Amtmann and Oyama 1973;Keil 1969).…”

Section: Discussionmentioning

confidence: 89%

Effects of centrifuging at 2g on rat long bone metaphyses

et al. 1999

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Hypergravity may be considered as a means of counteracting the deleterious effects of microgravity on bone tissue. The effects of exposure to 4 days of hypergravity provided by centrifuging, on bone tissue were studied using histomorphometry. Young 53-day-old male Sprague Dawley rats were randomly divided into a centrifuged group (2g, n = 10), a rotated group (ROTATE, n = 6) of rats exposed to 1.03 g placed in cages near the centre of rotation of the centrifuge and a stationary control group (CONTROL, n = 10). The body mass of the 2g rats was decreased by this experience by 16% compared to CONTROL. The width of the tibial growth plate of 2g was decreased. In two out of ten 2g rats, the hypertrophic zone was injured. In both the tibial and humeral primary (1 degrees ) spongiosae, a reduced 1 degrees spongiosa width (-35% and -24%, ROTATE versus CONTROL respectively; -37% and -41%, 2g versus CONTROL respectively) associated with bone gain (+27% for tibia and humerus ROTATE versus CONTROL; + 16% and +20%, 2g versus CONTROL respectively) was observed in both ROTATE and 2g. In the tibial secondary (2 degrees) spongiosa, bone mass was increased in the 2g (+13% 2g versus CONTROL) rats due to thicker trabeculae, but was decreased in ROTATE rats (-12% versus CONTROL) due to thinner trabeculae. The parameters of formation and resorption activities were stimulated in the 2g and ROTATE groups, the formation activity being more enhanced in 2g. No structural changes were observed in the humeral 2 degrees spongiosa in any of the groups. Numeral bone formation parameters were decreased in 2g and ROTATE but resorption activity was increased in 2g and decreased in ROTATE compared to CONTROL. In conclusion, as early as the 4th day, 2g hypergravity induced reduced endochondral bone formation and increased cancellous bone mass. Rotation led to mixed results including reduced endochondral bone formation, increased bone volume in the 1 degrees spongiosa and bone loss in the 2 degrees spongiosa.

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“…Since body weight is evaluated as b.w. = ma, where m = body mass, and a = acceleration (typically, a is the acceleration due to gravity), a desired, simulated increase in body weight can be accomplished by producing an appropriate increase in acceleration.The studies in the literature on the effects of hypergravity on bone growth are consistent in using accelerations greater than 2.OG (an effective doubling of body weight), and in reporting a repression of bone growth under hypergravity (Amtmann and Oyama, 1976; Briney and Wunder, 1962;Smith 1975Smith ,1977; and many others). However, when lambs were loaded by weights totaling 40% of total body weight (1.4G) positive bone growth effects were reported (Tulloh and Romberg, 1963).…”

mentioning

confidence: 68%

“…The studies in the literature on the effects of hypergravity on bone growth are consist-ent in using accelerations greater than 2.OG (an effective doubling of body weight), and in reporting a repression of bone growth under hypergravity (Amtmann and Oyama, 1976; Briney and Wunder, 1962;Smith 1975Smith ,1977; and many others). However, when lambs were loaded by weights totaling 40% of total body weight (1.4G) positive bone growth effects were reported (Tulloh and Romberg, 1963).…”

mentioning

confidence: 99%

The effects of simulated increases in body weight for 30 and 60 days on bone robusticity of limb bones in rats

1984

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The purpose of this study was to subject groups of weanling male rats each to a specific 10% simulated increase in body weight, ranging from 1.1G-2.0G, using constant centrifugation. (In this paper, "G" is the acceleration due to gravity.) After 30 and 60 days, rats were killed and perfused with 10% buffered neutral formalin (B.N.F.). The humerus, radius, ulna, femur, and tibia were removed, cleared of all soft tissues, weighed, and the total length measured. Bone robusticity was calculated using the ponderal index: bone length/3 square root bone weight. Tukey's Multiple Range Test was used. The data suggest that the specific limb bone, G, and duration of centrifugation are each factors in the response of limb bones to simulated increases in body weight.

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Growth of hamsters during continual centrifugation

Cited by 18 publications

References 0 publications

Altered Behaviour in Hamsters Conceived and Born in Hypergravity

Altered Behaviour in Hamsters Conceived and Born in Hypergravity

Effects of centrifuging at 2g on rat long bone metaphyses

The effects of simulated increases in body weight for 30 and 60 days on bone robusticity of limb bones in rats

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