Growth of Human Tumors in Hibernating Hamsters.

Wb, Patterson; Cp, Lyman; Hr, Patterson

doi:10.3181/00379727-96-23402

Cited by 10 publications

(2 citation statements)

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“…Inhibiting somatic cell apoptosis can to some extent prolong the natural cell survival cycle and ensure the necessary number of basal cells in the organism. Moreover, the inhibition of apoptosis of immune cells can maintain a certain degree of immunity with minimal energy consumption, preventing the emergence of massive cell death caused by microbial infection during dormancy ( Patterson et al, 1957 ).…”

Section: Discussionmentioning

confidence: 99%

Comparative transcriptomic evidence of physiological changes and potential relationships in vertebrates under different dormancy states

Niu,

Guan,

Wang

et al. 2024

Zoological Research

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Dormancy represents a fascinating adaptive strategy for organisms to survive in unforgiving environments. After a period of dormancy, organisms often exhibit exceptional resilience. This period is typically divided into hibernation and aestivation based on seasonal patterns. However, the mechanisms by which organisms adapt to their environments during dormancy, as well as the potential relationships between different states of dormancy, deserve further exploration. Here, we selected Perccottus glenii and Protopterus annectens as the primary subjects to study hibernation and aestivation, respectively. Based on histological and transcriptomic analysis of multiple organs, we discovered that dormancy involved a coordinated functional response across organs. Enrichment analyses revealed noteworthy disparities between the two dormant species in their responses to extreme temperatures. Notably, similarities in gene expression patterns pertaining to energy metabolism, neural activity, and biosynthesis were noted during hibernation, suggesting a potential correlation between hibernation and aestivation. To further explore the relationship between these two phenomena, we analyzed other dormancy-capable species using data from publicly available databases. This comparative analysis revealed that most orthologous genes involved in metabolism, cell proliferation, and neural function exhibited consistent expression patterns during dormancy, indicating that the observed similarity between hibernation and aestivation may be attributable to convergent evolution. In conclusion, this study enhances our comprehension of the dormancy phenomenon and offers new insights into the molecular mechanisms underpinning vertebrate dormancy.

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Section: Discussionmentioning

confidence: 99%

Comparative transcriptomic evidence of physiological changes and potential relationships in vertebrates under different dormancy states

Niu,

Guan,

Wang

et al. 2024

Zoological Research

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“…This signal can effectively inhibit the growth and development of autologous cells in these mammals. It can also be recognized and used by mammalian tumor cells that Frontiers in Genetics frontiersin.org cannot hibernate on their own (Bischoff et al, 1940;Lyman and Fawcett, 1954;Patterson et al, 1957). In the last century, Swan et al (1968) also found antimetabolic factors in the brains of aestivating African lungfish.…”

Section: Potential Cancer-inhibiting Abilitymentioning

confidence: 99%

Aestivation induces widespread transcriptional changes in the African lungfish

Niu

Guan²,

Wang³

et al. 2023

Front. Genet.

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Aestivation is a special ability possessed by some animals to cope with hot and dry environments utilizing dormancy. At a macroscopic level, dormant animals stop moving and eating. At the microscopic level, the expression of a large number of genes in these animals is strictly controlled. However, little is known about what changes occur during aestivation, especially in fish. In this study, we used transcriptome analysis to examine what changes occur in the gills and lungs of the African lungfish (Protopterus annectens) during the maintenance phase of aestivation and speculated on their causes. We found that aestivating transcriptomes were highly similar between gills and lungs. We also found that some genes showed differential expression or alternative splicing, which may be associated with different organs. In addition, differential expression analysis revealed that the lungs maintained significantly higher bioactivity during aestivation, which suggests that the main respiratory organ in aestivating lungfish can transform. Our study provides a reference point for studying the relationship between aestivation and hibernation and further increases understanding of aestivation.

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CRISPR Challenges and Opportunities for Space Travel

Gouw

2020

Human Enhancements for Space Missions

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Growth of Human Tumors in Hibernating Hamsters.

Cited by 10 publications

References 0 publications

Comparative transcriptomic evidence of physiological changes and potential relationships in vertebrates under different dormancy states

Comparative transcriptomic evidence of physiological changes and potential relationships in vertebrates under different dormancy states

Aestivation induces widespread transcriptional changes in the African lungfish

CRISPR Challenges and Opportunities for Space Travel

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