Growth of <i>Candida albicans</i> on the stratum corneum of diabetic and non‐diabetic patients

Rurangirwa, A.; Piérard‐Franchimont, C.; Piérard, G. E.

doi:10.1111/myc.1990.33.5.253

Cited by 15 publications

(8 citation statements)

References 18 publications

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“…5,12 Rurangirwa et al suggested that the inner face of the superficial layers of the stratum corneum of diabetics could be more prone to Candida invasion than that of non-diabetics. 13 In diabetic patients with vulvovaginal candidosis blood glucose level should be controlled in order to prevent future outbreakes of infection. 14 High concentration of glucose, arabinose and rybose in diet, enhances oral carriage, since Candida cells absorbs carbon from these sugars.…”

Section: Discussionmentioning

confidence: 99%

Species distribution and influence of glycemic control on fungal infections in pregnant women with diabetes

Nowakowska

Kurnatowska

Stray‐Pedersen

et al. 2004

Journal of Infection

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Section: Discussionmentioning

confidence: 99%

Species distribution and influence of glycemic control on fungal infections in pregnant women with diabetes

Nowakowska

Kurnatowska

Stray‐Pedersen

et al. 2004

Journal of Infection

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“…We have not explored in depth such findings which could indicate an indi vidual susceptibility of the human stratum corneum to fungal infections. This was shown in the past for C. albicans in diabetic and non diabetic patients [12].…”

Section: Discussionmentioning

confidence: 99%

“…The problem is even more difficult in the clin ical situation where diseases are obviously not standardized with regard to the strain and amount of the fungi, and to the inhibitory activity of the immune and nonimmune re sponses to the infectious agent. Experimental infections in volunteers do not eliminate the intervention of the host response which is [9,10], The aim of the present study is to improve on previous approaches made in our labora tory [10][11][12][13] to quantify the inhibition of fun gal growth on stratum corneum following standardized topical application of antifun gals commercially available in Europe.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of the Activity and Lingering Effect of Topical Antifungals

Pierard

Piérard-Franchimont

Estrada³

1993

Skin Pharmacol Physiol

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We present a combined method of culturing pathogenic der-matophytes and yeasts on human stratum corneum. Topical marketed antifungals are applied in vivo, and the stratum corneum is removed by cyanoacrylate skin surface strippings. After inoculation of the test organism, the extent of fungal growth is measured, indicating by comparison with controls the level of inhibitory effect of the antifungal. Other samples of stratum corneum collected at different time intervals after the arrest of antimicrobial treatment are used to evaluate the lingering effect of the drug. The combination of the data gained by these approaches close to the in vivo situation is used to introduce a classification of antifungals.

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“…47 This may explain the significant vulvar findings found in some women with diabetes with VVC. Furthermore, Segal et al 48 reported that adhesion (attachment) of C albicans to vaginal epithelial cells is increased in patients with diabetes compared with controls without diabetes.…”

Section: Glucosementioning

confidence: 97%

Genital Mycotic Infections in Patients With Diabetes

Nyirjesy

Sobel

2013

Postgraduate Medicine

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Patients with diabetes, especially those with poorly controlled glycemia, are prone to developing genital mycotic infections-vulvovaginal candidiasis in women and Candida balanitis in men-the latter almost exclusively in uncircumcised men. Candida albicans is the most common pathogen causing balanitis and is also the dominant cause of vulvovaginal candidiasis in women with diabetes, although Candida glabrata is a prominent pathogen in women with type 2 diabetes mellitus. Candida glabrata is less virulent but also less susceptible to conventional antifungal treatment. High blood glucose levels promote yeast attachment and growth, and also interfere with immune responses in the host. In uncircumcised men, the moist, warm space underneath the foreskin is thought to promote yeast growth, especially when hygiene is poor. Several other risk factors have been identified that predispose to genital mycotic infections, including antibiotic use, corticosteroid use, immunosuppression, atopy, and, in women only, genetics, pregnancy, estrogen/oral contraceptive use, and select sexual behaviors (eg, orogenital sex). In patients with hyperglycemia, risk is increased for not only incident infection but also for recurrence, underscoring the key role of establishing and maintaining euglycemia in the management of genital mycotic infections in patients with diabetes. In addition to blood glucose control, first-line treatment involves either an antifungal cream/ointment (or suppository for women only) that is applied intravaginally by women and directly to the affected area(s) by men, or oral treatment, which infrequently causes systemic side effects. Antifungal treatment should also be offered to sexual partners of patients with diabetes with a genital mycotic infection if the partner is similarly infected. Given high efficacy rates, follow-up test-of-cure after the completion of treatment is generally unnecessary.

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Growth of Candida albicans on the stratum corneum of diabetic and non‐diabetic patients

Cited by 15 publications

References 18 publications

Species distribution and influence of glycemic control on fungal infections in pregnant women with diabetes

Species distribution and influence of glycemic control on fungal infections in pregnant women with diabetes

Comparative Study of the Activity and Lingering Effect of Topical Antifungals

Genital Mycotic Infections in Patients With Diabetes

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