Growth of seventy-eight recurrent mammary cancers:Quantitative study

Philippe, E; Gal, Yaniv

doi:10.1002/1097-0142(196803)21:3<461::aid-cncr2820210317>3.0.co;2-v

Cited by 59 publications

(7 citation statements)

References 23 publications

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“…Fifteen months elapsed from tracheostomy placement and symptomatic diagnosis of the 3‐ × 4‐cm recurrent growth at the stoma site, a time interval that may seem exceedingly short for such a large recurrence to develop. However, in agreement with the short volume doubling time of breast cancer recurrences, reported to range between 25 and 51 days, we estimated that a micrometastasis growing up to 4 cm in diameter in 15 months would have a volume doubling time of about 30 days. Interestingly, a review of percutaneous endoscopic gastrostomy (PEG)–associated metastases from head and neck tumors reported that stomal recurrence became clinically evident at a mean of 8 months (range, 2–24 months) after PEG placement…”

Section: Discussionsupporting

confidence: 85%

Metastasis at a tracheostomy site as the presenting sign of late recurrent breast cancer

et al. 2013

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Section: Discussionsupporting

confidence: 85%

Metastasis at a tracheostomy site as the presenting sign of late recurrent breast cancer

et al. 2013

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“…Twelve studies included non‐inflammatory primary breast cancer only. Four studies included T4 tumors, local recurrences, and distant metastasis 4,10,27,28 . T stage at diagnosis was mainly T1 or T2.…”

Section: Resultsmentioning

confidence: 99%

Has tumor doubling time in breast cancer changed over the past 80 years? A systematic review

et al. 2021

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BACKGROUNDTumor doubling time (DT) is defined by the number of days required for a tumor to double its volume. A shorter DT indicates a faster tumor growth rate. 1 The duration of the cell cycle is similar in tumors and healthy tissues, but tumors present a higher proportion of cells undergoing mitosis. This proportion of cells is called: "the growth fraction", which is highly variable and dependent on the type of tumor. Metastases commonly have a growth rate almost twice that of the primary tumor. 2,3 Tumor DT is an important element for cancer progression prediction models and depends on the duration of the cell cycle, the growth fraction, and the rate of cell loss. 4 A better understanding

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“…Mean tumor diameter = e, where X and Y are the diameters (mm) of 2 orthogonal measurements. Doubling time was calculated according to the following equation (Estrada et al, 1989;Phillipe and LeGal, 1968):…”

Section: Spontaneous Metastasis Assaymentioning

confidence: 99%

Characterization of a highly invasive and spontaneously metastatic human malignant melanoma cell line

Welch¹,

Bisi²,

Miller³

et al. 1991

Intl Journal of Cancer

180

131

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Although the incidence of, and deaths due to, malignant melanoma are rising at a rapid rate, few experimental models mimic the highly metastatic properties associated with the pathogenesis of the human disease, making study of the disease difficult. Thus, new human models are required to understand melanoma biology, especially its metastatic properties. Here we describe C8161, a highly invasive and spontaneously metastatic human melanoma cell line, which grows progressively in the subcutis of athymic nude mice with an average doubling time of approximately 6 days. By the time the tumor reaches a diameter of 1 cm, amelanotic metastases in lymph nodes, skin, peritoneal wall, spleen and lungs have formed. By comparing C8161 to variants from other well-characterized human malignant melanomas (A375 and MeWo) with differing metastatic traits, properties presumed to be involved in metastatic propensity were examined. C8161 showed a 2- to 14-fold higher ability to invade reconstituted basement membrane barriers in the MICS and correspondingly high type-IV collagenase mRNA levels and collagenolytic activity, as compared with other melanoma cell lines. Likewise, differential adhesion to immobilized RBM or HUVEC monolayers was observed, but did not correlate to rank orders of malignant properties. Recently, a correlation between surface expression of ICAM-1 and secondary tumor formation by human melanomas has been described in several laboratories. Basal levels of ICAM-1 on C8161, A375 and MeWo human melanomas were compared, but no correlation with metastatic potential was noted. Proto-oncogene expression in C8161 cells was compared with A375P and A375M variants using Northern blot analysis. c-myc expression was 6-fold greater than both A375 variants; c-fos expression was 3.4-fold less than A375P and 1.7-fold less than A375M; c-jun in C8161 cells was 2.5-fold and 2.1-fold greater than expression in A375P and A375M, respectively. Because C8161 is so highly malignant, amenable to experimental manipulation, and its behavior in nude mice mimics the clinical course of malignant melanoma, this cell line will prove valuable for studying properties associated with human melanoma tumor progression.

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Growth of seventy-eight recurrent mammary cancers:Quantitative study

Cited by 59 publications

References 23 publications

Metastasis at a tracheostomy site as the presenting sign of late recurrent breast cancer

Metastasis at a tracheostomy site as the presenting sign of late recurrent breast cancer

Has tumor doubling time in breast cancer changed over the past 80 years? A systematic review

Characterization of a highly invasive and spontaneously metastatic human malignant melanoma cell line

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