In this study, 2D multimetallic MOFs combined with the advantages of 2D nanosheets, with the synergetic effect of multimetallic nodes, exhibited good photocatalytic activity for reduction of CO2. Herein, a 2D MOF‐Co/Cu/Fe were successfully prepared via one‐pot stirring of the solutions of multimetal salts and organic ligands at room temperature. Introduction of the second and third metal (Cu and Fe) into MOF‐Co does not change the 2D morphology of MOFs, although it improved the photocatalytic CO2 reduction performance by broadening the light absorption range of 2D MOF‐Co, accelerating the separation efficiency and transfer rate of photogenerated carriers. Upon irradiation with full‐spectrum light, the average CO yield of 2D MOF‐Co/Cu/Fe achieved 17.06 µmol·g−1·h−1, being about 1.8 and 1.2 times that of 2D MOF‐Co and 2D MOF‐Co/Cu. This work provides an insight into 2D multimetallic MOFs‐based photocatalysts in catalytic CO2 reduction.