Growth of strontium hydrogen phosphate/gelatin composites: a biomimetic approach

Gashti, Mazeyar Parvinzadeh; Stir, M.; Hulliger, Jürg

doi:10.1039/c5nj03575a

Cited by 36 publications

(33 citation statements)

References 47 publications

(68 reference statements)

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“…A promising approach to overcome these limitations, and also meet the biomimetic suggestion is to reinforce it with bioactive bioceramics to achieve an optimal tradeoff between bioactive and chemical behaviors, and physiomechanical properties [1,5]. Furthermore, some researchers reported the effect of GEL in bioactivity through modulating the diffusion of calcium ions that leads to enhance biomineralization specially when impregnated by various inorganic agents [14][15][16]. HA is a widely used bioactive phase in BTE scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Novel layered double hydroxides-hydroxyapatite/gelatin bone tissue engineering scaffolds: Fabrication, characterization, and in vivo study

Fayyazbakhsh

Solati‐Hashjin

Keshtkar

et al. 2017

Materials Science and Engineering: C

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Developing porous biodegradable scaffolds through simple methods is one of the main approaches of bone tissue engineering (BTE). In this work, a novel BTE composite containing layered double hydroxides (LDH), hydroxyapatite (HA) and gelatin (GEL) was fabricated using co-precipitation and solvent-casting methods. Physiochemical characterizations showed that the chemical composition and microstructure of the scaffolds were similar to the natural spongy bone. Interconnected macropores ranging over 100 to 600μm were observed for both scaffolds while the porosity of 90±0.12% and 92.11±0.15%, as well as, Young's modulus of 19.8±0.41 and 12.5±0.35GPa were reported for LDH/GEL and LDH-HA/GEL scaffolds, respectively. The scaffolds were degraded in deionized water after a month. The SEM images revealed that between two scaffolds, the LDH-HA/GEL with needle-like secondary HA crystals showed better bioactivity. According to the alkaline phosphatase activity and Alizarin red staining results, LDH-HA/GEL scaffolds demonstrated better bone-specific activities comparing to LDH/Gel scaffold as well as control sample (P<0.05). The rabbit adipose stem cells (ASCs) were extracted and cultured, then seeded on the LDH-HA/GEL scaffolds after confluence. Three groups of six adult rabbits were prepared: the scaffold+ASCs group, the empty scaffold group and the control group. The critical defects were made on the left radius and the scaffolds with or without ASCs were implanted there while the control group was left without any treatment. All animals were sacrificed after 12weeks. Histomorphometric results showed that the regeneration of defects was accelerated by scaffold implantation but ASC-seeding significantly improved the quality of new bone formation (P<0.05). The results confirmed the good performance of LDH-HA/GEL scaffold to induce bone regeneration.

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Section: Introductionmentioning

confidence: 99%

Novel layered double hydroxides-hydroxyapatite/gelatin bone tissue engineering scaffolds: Fabrication, characterization, and in vivo study

Fayyazbakhsh

Solati‐Hashjin

Keshtkar

et al. 2017

Materials Science and Engineering: C

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“…The second thermal degradation for composite particles is due to the removal of chemisorbed and coordinated water molecules, as well as gelatin entrapment in sheets. We recently demonstrated this change at a higher temperature of 200°C for calcium hydrogen phosphate, barium hydrogen phosphate, and strontium hydrogen phosphate sheets . It should be expressed that the thermal degradation at the second region is due to the pyrolytic breakage between the gelatin polar groups of amine and carboxylic acids on the one hand and the zinc and phosphate ions of ZP/gelatin composite crystals.…”

Section: Resultsmentioning

confidence: 92%

“…Note that, the ionic strength of gelatin can be modulated via zinc ions, therefore, the number of hydrogen bonds and the coupling of zinc ions with the gelatin carboxylate anions can be changed due to pH changes in gel. We postulate that zinc ions are probably able to produce parallel conformations of peptides and ordering of triple helices resulting to sheet‐like structures of ZP …”

Section: Resultsmentioning

confidence: 99%

“…We postulate that zinc ions are probably able to produce parallel conformations of peptides and ordering of triple helices resulting to sheet-like structures of ZP. 21,22 The XRD diffractograms recorded for gelatin-free ZP as well as the ZP/gelatin nanocomposite sheets synthesized at different pH are presented in Fig. 3.…”

Section: à2mentioning

confidence: 99%

“…We recently demonstrated this change at a higher temperature of 200°C for calcium hydrogen phosphate, barium hydrogen phosphate, and strontium hydrogen phosphate sheets. 13,14,22 It should be expressed that the thermal degradation at the second region is due to the pyrolytic breakage between the gelatin polar groups of amine and carboxylic acids on the one hand and the zinc and phosphate ions of ZP/gelatin composite crystals. Similar results were observed in our former studies on calcium hydrogen phosphate, barium hydrogen phosphate, and strontium hydrogen phosphate composite samples produced in gelatin hydrogel.…”

Section: à2mentioning

confidence: 99%

See 2 more Smart Citations

Biomineralization‐Inspired Green Synthesis of Zinc Phosphate‐Based Nanosheets in Gelatin Hydrogel

Gashti

Helali

Karimi

2016

Int J Applied Ceramic Tech

Self Cite

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Diffusion of inorganic salts in gels is a simple, inexpensive, and versatile technique for the synthesis of inorganic/organic hybrid nanocomposite particles with various morphologies. This paper introduces a novel method for producing zinc phosphate (ZP) nanosheets using single diffusion of zinc ions in gelatin at ambient temperature. FTIR spectra showed the entrapment of gelatin in ZP sheets due to electrostatic interactions between charged groups of gelatin and diffused ions. This study demonstrated that hydrogels can be used for crystallization of ZP. Such a nanocomposite particle may open a new window for producing antimicrobial and materials for use in tissue engineering.

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Unraveling Structural and Acidic Properties of Al‐SBA‐15‐supported Metal Phosphates: Assessment for Glucose Dehydration

Rakngam,

Khemthong,

Osakoo

et al. 2023

ChemPlusChem

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5‐hydroxymethylfurfural (5‐HMF) synthesized through glucose conversion requires Lewis acid (L) site for isomerization and Brønsted acid (B) site for dehydration. The objective of this work is to investigate the influence of the metal type of Al‐SBA‐15‐supported phosphates of Cr, Zr, Nb, Sr, and Sn on glucose conversion to 5‐HMF in a NaCl‐H2O/n‐butanol biphasic solvent system. The structural and acid property of all supported metal phosphate samples were fully verified by several spectroscopic methods. Among those catalysts, CrPO/Al‐SBA‐15 provided the best performance with the highest glucose conversion and 5‐HMF yield, corresponding to the highest total acidity of 0.65 mmol/g and optimal L/B ratio of 1.88. For CrPO/Al‐SBA‐15, another critical parameter is the phosphate‐to‐chromium ratio. Moreover, DFT simulation of glucose conversion to 5‐HMF on the surface of the optimized chromium phosphate structure reveals three steps of fructose dehydration on the Brønsted acid site. Finally, the optimum reaction condition, reusability, and leaching test of the best catalyst were determined. CrPO/Al‐SBA‐15 is a promising catalyst for glucose conversion to high‐value‐added chemicals in future biorefinery production.

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Growth of strontium hydrogen phosphate/gelatin composites: a biomimetic approach

Abstract: Our study has focused on the crystal growth of strontium phosphates via gel growth method due to the bioactivity and biocompatibility of these materials with bone tissue.

Cited by 36 publications

References 47 publications

Novel layered double hydroxides-hydroxyapatite/gelatin bone tissue engineering scaffolds: Fabrication, characterization, and in vivo study

Novel layered double hydroxides-hydroxyapatite/gelatin bone tissue engineering scaffolds: Fabrication, characterization, and in vivo study

Biomineralization‐Inspired Green Synthesis of Zinc Phosphate‐Based Nanosheets in Gelatin Hydrogel

Unraveling Structural and Acidic Properties of Al‐SBA‐15‐supported Metal Phosphates: Assessment for Glucose Dehydration

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