Growth pattern of rabbit fetuses during normal pregnancy and with inhibition of the “gestation dominant”

Bal'magiya, T. A.; Surovtseva, Z. F.

doi:10.1007/bf00798092

Cited by 4 publications

(2 citation statements)

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“…Nevertheless, further studies are required to comprehend the underlying mechanisms and the extent to which the consequences may reach [71]. Stress in pregnant does can trigger several outcomes, depending on the pregnancy period in which they are subjected to the stressful stimuli [72].…”

Section: Maternal Stressmentioning

confidence: 99%

“…On the other hand, when the stress was induced at the end of the fetal period (from days 25 to 27), it increased the size of the placenta, accelerated the growth of the organs, and increased the fetuses' weight when compared to controls. This interesting event can be an adaptative reaction of the fetus in response to stress [72]. Rabbits have very sensitive hearing and were already associated with a threshold area lying between 0 and 20 dB in the sensitive range.…”

Section: Maternal Stressmentioning

confidence: 99%

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Pregnancy Complications and Feto-Maternal Monitoring in Rabbits

Pinto-Pinho,

Pinto,

Monteiro

et al. 2023

Veterinary Sciences

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Rabbit production holds significant relevance in modern agriculture due to its potential as a sustainable source of high-quality protein and efficient feed conversion, contributing to food security and economic diversification. Nevertheless, studies incorporating feto-maternal monitoring in this species are uncommon. This review gathers research on the monitoring and evaluation of factors affecting rabbit gestation, providing a better understanding of the causes of prenatal development abnormalities. These include studies regarding how chronic maternal hypertension, gestational diabetes, maternal stress, ectopic gestation, maternal uterine ischemia and fetal hypoxia, intrauterine growth restriction, superfetation, maternal age, maternal nutritional status, maternal physical condition, maternal and embryonic genotype, and the intrauterine location of rabbit fetuses can potentially impact rabbits’ reproduction and maternal and fetal health. Among other monitoring techniques, ultrasonography, considered one of the best tools for diagnosing pregnancy and conducting follow-up, is also reviewed. Details on measurable fetal-development parameters in rabbits and precautions to be considered before and during the examination are also provided. Additional studies are required to understand why some events occur and their consequences throughout gestation, allowing the determination of new biomarkers or cut-offs that can be helpful for early diagnosis and improve reproductive efficiency.

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Section: Maternal Stressmentioning

confidence: 99%

Section: Maternal Stressmentioning

confidence: 99%

Pregnancy Complications and Feto-Maternal Monitoring in Rabbits

Pinto-Pinho,

Pinto,

Monteiro

et al. 2023

Veterinary Sciences

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Models of Intrauterine growth restriction and fetal programming in rabbits

López-Tello

Álvarez

González-Bulnes³

et al. 2019

Molecular Reproduction Devel

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Intrauterine growth restriction (IUGR) affects approximately 10% of human pregnancies globally and has immediate and life‐long consequences for offspring health. However, the mechanisms underlying the pathogenesis of IUGR and its association with later health and disease outcomes are poorly understood. To address these knowledge gaps, the use of experimental animals is critically important. Since the 50's different environmental, pharmacological, and surgical manipulations have been performed in the rabbit to improve our knowledge of the control of fetal growth, fetal responses to IUGR, and mechanisms by which offspring may be programmed by an adverse gestational environment. The purpose of this review is therefore to summarize the utility of the rabbit as a model for IUGR research. It first summarizes the knowledge of prenatal and postnatal development in the rabbit and how these events relate to developmental milestones in humans. It then describes the methods used to induce IUGR in rabbits and the knowledge gained about the mechanisms determining prenatal and postnatal outcomes of the offspring. Finally, it discusses the application of state of the art approaches in the rabbit, including high‐resolution ultrasound, magnetic resonance imaging, and gene targeting, to gain a deeper integrative understanding of the physiological and molecular events governing the development of IUGR. Overall, we hope to engage and inspire investigators to employ the rabbit as a model organism when studying pregnancy physiology so that we may advance our understanding of mechanisms underlying IUGR and its consequences in humans and other mammalian species.

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Ultrasound Local Heating Improve Foetal Physiological Development in Maternal Hyperparathyroidism

Hashim

Dom

2016

Jurnal Teknologi

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Parathyroid disorder associated with hypercalcemia during pregnancy reduces the normal foetal growth, skeletal mineralization and serum calcium concentration. Hypercalcemia increases the risk of birth loss and foetal postpartum complications which includes intrauterine growth retardation, low birth weight, preterm delivery, neonatal hypocalcaemia, tetany and still-birth. Human and animal study exhibit benefits from local hyperthermia induced by ultrasound exposure. Ten-month-old primiparous New Zealand White (NZW) does were assigned into three different groups; control (C), healthy NZW does and free from ultrasound insonation; hyperparathyroidism (HPT), a positive control group having hypercalcemia conditions established through administering phosphate intravenously for 5 months and free from parathyroid ultrasound insonation; treatment (T), an experimental group experiencing hypercalcemia condition and receiving parathyroid ultrasound insonation during pregnancy as intervention to hyperparathyroidism. In treatment group rabbit were exposed for 30, 60 and 90 minutes of parathyroid ultrasound exposure on 1st, 2nd and 3rd gestational stage accordingly. Following birth, foetal serum calcium (SCa), body weight (BW), crown-to-rump length (CRL), total body length (TBL), bi-parietal diameter (BPD) and femur length (FL) of the foetal were measured. Maternal hypercalcemia during pregnancy produced small to gestational age (SGA) progeny with significant reduction of BW, CRL, TBL, BPD, FL and SCa compared to normal. While the outcome of ultrasound exposure given during middle 2nd gestational stage resulted in significantly increase in progeny mean average BW, CRL, TBL, BPD FL and SCa compared to HPT group. Ultrasound induced local heating demonstrated an improved in the physiological development of progeny in the cases of maternal hypercalcemia condition.

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Growth pattern of rabbit fetuses during normal pregnancy and with inhibition of the “gestation dominant”

Cited by 4 publications

References 0 publications

Pregnancy Complications and Feto-Maternal Monitoring in Rabbits

Pregnancy Complications and Feto-Maternal Monitoring in Rabbits

Models of Intrauterine growth restriction and fetal programming in rabbits

Ultrasound Local Heating Improve Foetal Physiological Development in Maternal Hyperparathyroidism

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