Growth performance, intestinal histomorphology, gut microflora and ghrelin gene expression analysis of broiler by supplementing natural growth promoters: A nutrigenomics approach

Gilani, Syed Muddassar Hussain; Rashid, Zubia; Galani, Saddia; Ilyas, Sahar; Sahar, Shagufta; Hassan, Zahoor Ul; Al‐Ghanim, Khalid A.; Zehra, Sitwat; Azhar, Abid; Al‐Misned, Fahad A.; Ahmed, Z.; Al-Mulham, N.; Mahboob, Shahid

doi:10.1016/j.sjbs.2021.03.008

Cited by 18 publications

(10 citation statements)

References 33 publications

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“…The nutrients' toxic and potentially detrimental effects should also be investigated in detail. A detailed investigation of the nutrigenomic effects of the nutrients will help farmers formulate better feed formulations and curtail the use of antibiotics, the resistance against which is becoming an alarming situation around the world [ 178 , 179 ].…”

Section: Strategies To Alleviate Biological Stress During the Transit...mentioning

confidence: 99%

Nutrigenomic Interventions to Address Metabolic Stress and Related Disorders in Transition Cows

Hassan

Nadeem

Javed

et al. 2022

BioMed Research International

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For dairy cattle, the period involving a shift from late pregnancy to early lactation termed transition or periparturient is an excruciating phase. Health-related disorders are likely to happen in this time frame. Timely postpartum and metabolic adjustments to this new physical state demands correct management strategies to fulfill the cow’s needs for a successful transition to this phase. Among the management strategies, one of the most researched methods for managing transition-related stress is nutritional supplementation. Dietary components directly or indirectly affect the expression of various genes that are believed to be involved in various stress-related responses during this phase. Nutrigenomics, an interdisciplinary approach that combines nutritional science with omics technologies, opens new avenues for studying the genome’s complicated interactions with food. This revolutionary technique emphasizes the importance of food-gene interactions on various physiological and metabolic mechanisms. In animal sciences, nutrigenomics aims to promote the welfare of livestock animals and enhance their commercially important qualities through nutritional interventions. To this end, an increasing volume of research shows that nutritional supplementation can be effectively used to manage the metabolic stress dairy cows undergo during the transition period. These nutritional supplements, including polyunsaturated fatty acids, vitamins, dietary amino acids, and phytochemicals, have been shown to modulate energy homeostasis through different pathways, leading to addressing metabolic issues in transition cows.

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Section: Strategies To Alleviate Biological Stress During the Transit...mentioning

confidence: 99%

Nutrigenomic Interventions to Address Metabolic Stress and Related Disorders in Transition Cows

Hassan

Nadeem

Javed

et al. 2022

BioMed Research International

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“…Our result concerning the IGF-1 and GHr has supported the growth performance traits. This result was supported by [ 66 ], which revealed that liquorice ( Glycyrrhiza glabra ) was utilized to increase feed efficiency. The phytobiotics’ anti-bacterial, immunomodulatory, antioxidative, and growth-promoting capabilities and their abundance of physiologically active chemicals may be to blame for the increased weight gain in the host [ 67 ].…”

Section: Discussionmentioning

confidence: 60%

Licorice Extract Supplementation Affects Antioxidant Activity, Growth-Related Genes, Lipid Metabolism, and Immune Markers in Broiler Chickens

Abo-Samaha

Alghamdi

El-Shobokshy

et al. 2022

Life

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The objective of this study was to evaluate the Glycyrrhiza glabra effect on growth performance, blood parameters, antioxidant and lysosomal activity, histology and immunohistochemistry of liver and intestine, and the gene expression profile of broiler chickens. A total of 180 Cobb500 broiler chicks (one-week-old) were used in this study. Chicks were distributed randomly into three treatment groups; the first group received drinking water without any supplementation (control group). In contrast, birds in groups 2 and 3 received licorice supplementation in drinking water with 0.4 and 0.8 g licorice/liter, respectively. Results revealed that licorice at a 0.4 g/L of water level improved body weight, weight gain, feed intake, and FCR. Licorice also exhibits a broad range of biological activities such as hypolipidemic, hypoglycemic, hepatoprotective, immunostimulant, and antioxidant effects. The morphometric analysis of different parameters of the intestine revealed a significant increase in the intestinal villi length, width, and villi length/crypt depth in the group supplemented with licorice 0.4 gm/L compared to other groups. The number of CD3 positive in both duodenum and ileum was increased in the licorice 0.4 gm/L group compared to other groups. The expression of growth-related genes was significantly increased with licorice supplementation and modulation of the lipid metabolism genes in the liver and upregulated to the mRNA expression of both superoxide dismutase (SOD1) and Catalase (CAT). Our results revealed that licorice supplementation increased the growth performance of broiler chickens and impacted the birds’ antioxidant activity through modulation of the growth-related genes, lipid metabolic markers, and antioxidant-related pathways.

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“…However, no effects on egg production, shell-less eggs' rate, or egg weight have been previously reported when red garlic cloves are used in laying hens feeding or the combination of garlic and onion extracts [35,36]. Other effects have been informed by the use of other growth promoters, phytobiotics, organic acids, and their combination [37]; for example, the use of a phytobiotic mixture composed by ginger rhizome, liquorice, ashwagandha roots, black seeds, and leaves of green tea in the supplementation of one-day-old chickens, alone or in combination with organic acids, resulted in an increase in feed intake and body weight in the phytobiotic-supplemented birds, as well as improving the villus height and villusheight/crypt-depth ratio in ileum, jejunum, and duodenum while down regulating the ghrelin gene expression. Results also suggested that Lactobacillus spp.…”

Section: Discussionmentioning

confidence: 99%

Allium-Based Phytobiotic for Laying Hens’ Supplementation: Effects on Productivity, Egg Quality, and Fecal Microbiota

et al. 2022

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The poultry industry is constantly demanding novel strategies to improve the productivity and health status of hens, prioritizing those based on the holistic use of natural resources. This study aimed to assess the effects of an Allium-based phytobiotic on productivity, egg quality, and fecal microbiota of laying hens. One hundred and ninety-two 14-week-old Lohmann Lite LSL hens were allocated into an experimental farm, fed with a commercial concentrate with and without the Allium-based phytobiotic, and challenged against Salmonella. Productivity, egg quality, and fecal microbiota were monitored for 20 weeks. Results showed that the phytobiotic caused an increase on the number of eggs laid (p < 0.05) and in the feed conversion rate (p < 0.05); meanwhile, egg quality, expressed as egg weight, albumin height, haugh units, egg shell strength, and egg shell thickness remained unchanged (p > 0.05), although yolk color was decreased. Fecal microbiota structure was also modified, indicating a modulation of the gut microbiota by increasing the presence of Firmicutes and Bacteroidetes but reducing Proteobacteria and Actinobacteria phyla. Predicted changes in the functional profiles of fecal microbiota suggest alterations in metabolic activities that could be responsible for the improvement and maintenance of productivity and egg quality when the phytobiotic was supplemented; thus, Allium-based phytobiotic has a major impact on the performance of laying hens associated with a possible gut microbiota modulation.

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Growth performance, intestinal histomorphology, gut microflora and ghrelin gene expression analysis of broiler by supplementing natural growth promoters: A nutrigenomics approach

Cited by 18 publications

References 33 publications

Nutrigenomic Interventions to Address Metabolic Stress and Related Disorders in Transition Cows

Nutrigenomic Interventions to Address Metabolic Stress and Related Disorders in Transition Cows

Licorice Extract Supplementation Affects Antioxidant Activity, Growth-Related Genes, Lipid Metabolism, and Immune Markers in Broiler Chickens

Allium-Based Phytobiotic for Laying Hens’ Supplementation: Effects on Productivity, Egg Quality, and Fecal Microbiota

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