Growth Profiles of human autosomal trisomies at midgestation

Barr, Mason

doi:10.1002/tera.1420500605

Cited by 14 publications

(19 citation statements)

References 18 publications

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“…Splenomegaly and renomegaly have been documented in trisomy 13 [Barr, 1994a]. It can be speculated that the splenomegaly may be related to abnormal hemoglobin found in trisomy 13 [Gorlin et al, 1990].…”

Section: Resultsmentioning

confidence: 95%

“…While cystic renal disease is fairly common in trisomy 13, the cases analyzed showed no renal cysts but were nonetheless quite large. No clear evidence of visceromegaly was found in trisomy 18 or trisomy 21 [Barr, 1994a]. In the case of anencephaly, after adjusting for the effect of the absent brain, it was evident that thymus weight was increased and progressively so as age increased [Barr, 1997a].…”

Section: Resultsmentioning

confidence: 99%

“…All weights used in this study were measured by one prosector using the same equipment and techniques. Fetuses with autosomal trisomies, Ullrich-Turner syndrome, or anencephaly were excluded since they were the subject of separate analyses [Barr, 1994a[Barr, ,b, 1997a. Twins were included as a check of the validity of the screening method and to search for correlation with maternal characteristics and gestational events.…”

Section: Methodsmentioning

confidence: 99%

“…A number of these analyses have been reported [Johnson et al, 1989;Pridjian et al, 1991;Barr, 1994aBarr, ,b, 1997a. Here I will explore the occurrence of visceromegaly among fetuses with certain types of anomalies and those sharing some particular gestational experiences or maternal characteristics.…”

Section: Introductionmentioning

confidence: 95%

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Correlates of prenatal visceromegaly

Barr

1998

Am. J. Med. Genet.

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Aside from recognized overgrowth syndromes, instances of visceromegaly are not uncommon at perinatal autopsy. The database of the University of Michigan Teratology Unit was screened for individual viscera exceeding the 90th centile for body and brain weight standards. The data were stratified for several maternal (hypertension, diabetes, obesity), gestational (chorioamnionitis, oligohydramnios, amniorrhaea, polyhydramnios), and fetal (body wall defect, cardiac malformation, renal malformation, diaphragmatic hernia, nonimmune hydrops, twin transfusion syndrome) characteristics and tested for statistically significant excessive numbers of heavy organs. The most striking associations were heavy adrenal glands and liver with chorioamnionitis, heavy heart with polyhydramnios and in the twin transfusion syndrome, and heavy heart and liver with nonimmune hydrops. Excessive brain weight for body weight had a number of correlations, each most likely reflecting growth restriction with sparing of brain growth.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

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Correlates of prenatal visceromegaly

Barr

1998

Am. J. Med. Genet.

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“…(Lockwood et al 1987;Benacerraf et al 1987) The other biometric parameters were also evaluated, but the most significant changes were observed in the length of the extremities. (Barr Jr M.;1994) Various criteria have been described for the determination of short FL. Lockwood and Brumsfield used the biparietal diameter (BPD) to FL ratio in order to evaluate the risk of Down syndrome.…”

Section: Femur Length and Aneuplodiesmentioning

confidence: 99%

Prenatal Evaluation of Fetuses Presenting with Short Femurs

Uğurlucan¹,

Kayserili²,

Yüksel³

2012

Prenatal Diagnosis - Morphology Scan and Invasive Methods

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Organ asymmetries as correlates of other anomalies

Barr

2001

Am. J. Med. Genet.

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Fetuses with deviations in the normal left versus right weight relationships of the paired viscera were examined for correlation with particular malformations, syndromes, or other common factors. Alterations of the normal pattern were observed among cases with cytogenetic anomalies, diaphragmatic hernia, renal duplication, dyshydramnios, and single umbilical artery. A reversal of the left versus right weight pattern was found in the adrenals of cases with hepatic situs inversus but not in those with heterotaxic cardiac lesions. Recipient twins in the twin-twin transfusion syndrome had reduced left lung weights, presumably because of inhibition of lung growth by the enlarged heart. The side of umbilical artery absence did not predict either the nature or complexity of associated malformations. However, it is suggestive that there is discordance between the side of the missing artery and unilateral renal abnormality and that there is preferential absence of the right or left artery, depending on the karyotype.

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Growth Profiles of human autosomal trisomies at midgestation

Cited by 14 publications

References 18 publications

Correlates of prenatal visceromegaly

Correlates of prenatal visceromegaly

Prenatal Evaluation of Fetuses Presenting with Short Femurs

Organ asymmetries as correlates of other anomalies

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