Growth Rate of Liver Metastases From Stomach and Colonic Cancer by Tumor Marker and It's Clinical Significance

Mai, Masayoshi; Akimoto, Ryuichi; Kusama, Satoru

doi:10.5833/jjgs.18.927

Cited by 5 publications

(2 citation statements)

References 3 publications

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“…The tumor marker doubling time was calculated to be nearly equal to the tumor doubling time obtained from images from the same patients. Takahashi concluded that the tumor marker doubling time represented the cancer growth rate and was clinically useful as a surrogate to determine the tumor doubling time [ 46 ].…”

Section: Tumor Growth Ratementioning

confidence: 99%

“…Regarding lung metastases, it was previously reported that the mean tumor doubling time for metastasis from colorectal cancers was 109–118 days [ 36 , 37 , 49 ]. Moreover, the tumor doubling times for liver metastasis and gastric/colorectal cancers were observed to be 24.7 ± 11.8 and 68.2 ± 33.4 days, respectively [ 46 ]. The tumor doubling time for lung metastases was also longer than that for liver metastases and there was a tendency for the growth rate of lung metastases to be slower.…”

Section: Tumor Growth Ratementioning

confidence: 99%

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Chronology of gastrointestinal cancer

Murakami

Matsubara

2017

Surg Today

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The “chronology of cancer” is a concept that describes the nature of cancers through the measure of time. The field extends from carcinogenesis to development, progression, and metastasis. Carcinogenesis is a multi-step process, which results from the accumulation of multiple genetic or epigenetic alterations. Various chronologies of gastrointestinal cancers have been reported for carcinogenesis caused by different risk factors. These chronologies are useful for developing cancer prevention strategies. The tumor growth rate is one of the most important factors in this field. Combining the factors of time and tumor growth enables us to estimate the time at which cancer or metastasis occurred, retrospectively, and to predict the survival of cancer patients, prospectively. It is noteworthy that these chronologies differ significantly among individual cases, even of cancers derived from the same organ. Thus, they are useful for individualization. We can apply the knowledge obtained in this field to the basic research and the diagnosis and treatment of cancers. The chronology of cancer is a classical but interesting field, which helps us consider and explore the essence of cancer. We review the topics related to the chronology of gastrointestinal cancer, ranging from carcinogenesis to metastasis.

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Section: Tumor Growth Ratementioning

confidence: 99%

Section: Tumor Growth Ratementioning

confidence: 99%

Chronology of gastrointestinal cancer

Murakami

Matsubara

2017

Surg Today

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Factors influencing growth rate of recurrent stomach cancers as determined by analysis of serum carcinoembryonic antigen

Mai

Kusama²

1995

Cancer

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Background. Although there are many reports regarding the growth rate of human tumors, those discussing stomach cancer are rare due to the difficulty in evaluating the growth rate of stomach cancer. Stomach cancers grow with either a large central depression or through severe invasion. Metastatic sites of stomach cancer, however, grow expandingly, as with pulmonary tumors. Methods. The reported doubling time estimate, based on the serum level of carcinoembryonic antigen (CEA), agreed with the actual tumor doubling time investigated in 112 previously untreated patients with recurrent gastric cancers. The influencing factors of the CEA doubling time were studied clinicopathologically, and a possible correlation between postoperative survival and the CEA doubling time was noted. Results. The CEA doubling time ranged from 12 to 105 days, with a mean of 37.5 ± 20.5 days (mean ± standard deviation) and a median of 32 days. The CEA doubling time did not differ significantly between sexes or between patients of varying ages. However, the CEA doubling time was significantly shorter in patients with papillary adenocarcinoma than in those with well or moderately differentiated tubular adenocarcinoma. The CEA doubling time of patients with poorly differentiated adenocarcinoma was divided into two groups—a shorter one and a longer one. The doubling time was also significantly shorter in patients with liver metastasis than in those with lymph node metastasis or peritoneal dissemination. Furthermore, among patients who did not receive any chemotherapy, a significant correlation was observed between the CEA doubling time and postoperative survival time. Most treated patients survived longer than untreated patients. Conclusion. The influencing factors on growth rates in recurrent stomach cancers were histologic type and metastatic sites. This growth rate plays an important role in determining the degree of biologic malignancy and may be influenced by some chemotherapeutic regimens. Cancer 1995;75:1497‐502.

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α‐fetoprotein‐producing rectal cancer: Calculated tumor marker doubling time

Satō

Sekine

Ohwada

1994

Journal of Surgical Oncology

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alpha-fetoprotein (AFP) production by rectal cancer is very rare. In the English literature there are only a few reported cases in which serum AFP level was > 1,000 ng/ml. A 43-year-old Japanese man with rectal cancer and liver metastases had a high serum AFP level (941 ng/ml) when first evaluated. Three weeks later, the serum AFP level was extremely elevated (7,060 ng/ml). He underwent abdominoperineal excision of the rectum and biopsy of liver metastases. The placement of an intrahepatic-arterial infusion catheter into the proper hepatic artery via the right gastroepiploic artery was also performed. Immunohistochemically, AFP-positive cells were identified in both the rectal and liver tumors. Nine days postoperatively, the serum AFP level was 2,000 ng/ml. In spite of intensive chemoimmunotherapy, serum AFP level was increased and 14 weeks after surgery was extremely elevated (267,300 ng/ml). The patient succumbed to cancer 3 months after surgery. To our knowledge, this is the first case of an AFP-producing rectal cancer in which AFP doubling time could be calculated as 12.8 days.

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Growth Rate of Liver Metastases From Stomach and Colonic Cancer by Tumor Marker and It's Clinical Significance

Cited by 5 publications

References 3 publications

Chronology of gastrointestinal cancer

Chronology of gastrointestinal cancer

Factors influencing growth rate of recurrent stomach cancers as determined by analysis of serum carcinoembryonic antigen

α‐fetoprotein‐producing rectal cancer: Calculated tumor marker doubling time

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