Growth rates of metastatic brain tumors in nonsmall cell lung cancer

Yoo, Heon; Nam, Byung–Ho; Yang, Hee-Seok; Shin, Sang Hoon; Lee, Jin Soo; Lee, Jun Young

doi:10.1002/cncr.23676

Cited by 18 publications

(11 citation statements)

References 24 publications

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“…The results of this study showed that the median growth rate was 11.7 mm 3 /day, and this was almost same as our previous finding, 12.1 mm 3 /day [2].…”

Section: Discussionsupporting

confidence: 91%

“…The behavior of the metastatic brain tumor cells may be different (stage IV). (2) Tumor environment (angiogenesis, invasion, and growth factors) may be different in stage I and IV patients. (3) There may be a different tumor environment (extracellular matrix) of the lungs and brain.…”

Section: Discussionmentioning

confidence: 99%

“…Previously, we reported on the growth kinetics of metastatic brain tumors in patients with non-small cell lung cancer during chemotherapy, and calculated the growth rate after the development of chemo-resistance [2]. Thirty synchronous minimally symptomatic or asymptomatic metastatic brain tumors in 19 patients with non-small cell lung cancer that were treated with front-line chemotherapy until disease progression was detected by serial volumetric MRIs.…”

Section: Introductionmentioning

confidence: 99%

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Growth rate of newly developed metastatic brain tumors after thoracotomy in patients with non-small cell lung cancer

Yoo¹,

Jung²,

Nam³

et al. 2011

Lung Cancer

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“…The results of this study showed that the median growth rate was 11.7 mm 3 /day, and this was almost same as our previous finding, 12.1 mm 3 /day [2].…”

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Growth rate of newly developed metastatic brain tumors after thoracotomy in patients with non-small cell lung cancer

Yoo¹,

Jung²,

Nam³

et al. 2011

Lung Cancer

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“…This was calculated by using the measurements of the largest metastasis and the time from the date of surgery and the change in diameter of lesions over time using this volume doubling time (rounded to 60 days), assuming the metastases were spherical based [6]. We plotted the change in diameter over time of 2 mm and 5 mm diameter lesions and then plotted the maximum tumour diameter measured on the diagnostic scan against the number of days after surgery that the imaging was performed and the data of surgery was time 0.…”

Section: Methodsmentioning

confidence: 99%

Brain imaging before primary lung cancer resection: a controversial topic

Hudson¹,

Internullo²,

Edey³

et al. 2017

ecancer

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ObjectiveInternational and national recommendations for brain imaging in patients planned to undergo potentially curative resection of non-small-cell lung cancer (NSCLC) are variably implemented throughout the United Kingdom [Hudson BJ, Crawford MB, and Curtin J et al (2015) Brain imaging in lung cancer patients without symptoms of brain metastases: a national survey of current practice in England Clin Radiol https://doi.org/10.1016/j.crad.2015.02.007]. However, the recommendations are not based on high-quality evidence and do not take into account cost implications and local resources. Our aim was to determine local practice based on historic outcomes in this patient cohort.MethodsThis retrospective study took place in a regional thoracic surgical centre in the United Kingdom. Pathology records for all patients who had undergone lung resection with curative intent during the time period January 2012–December 2014 were analysed in October 2015. Electronic pathology and radiology reports were accessed for each patient and data collected about their histological findings, TNM stage, resection margins, and the presence of brain metastases on either pre-operative or post-operative imaging. From the dates given on imaging, we calculated the number of days post-resection that the brain metastases were detected.Results585 patients were identified who had undergone resection of their lung cancer. Of these, 471 had accessible electronic radiology records to assess for the radiological evidence of brain metastases. When their electronic records were evaluated, 25/471 (5.3%) patients had radiological evidence of brain metastasis. Of these, five patients had been diagnosed with a brain metastasis at initial presentation and had undergone primary resection of the brain metastasis followed by resection of the lung primary. One patient had been diagnosed with both a primary lung and a primary bowel adenocarcinoma; on review of the case, it was felt that the brain metastasis was more likely to have originated from the bowel cancer. One had been clinically diagnosed with a cerebral abscess while the radiology had been reported as showing a metastatic deposit. Of the remaining 18/471 (3.8%) patients who presented with brain metastases after their surgical resection, 12 patients had adenocarcinoma, four patients had squamous cell carcinoma, one had basaloid, and one had large-cell neuroendocrine. The mean number of days post-resection that the brain metastases were identified was 371 days, range 14–1032 days, median 295 days (date of metastases not available for two patients).ConclusionThe rate of brain metastases identified in this study was similar to previous studies. This would suggest that preoperative staging of the central nervous system may change the management pathway in a small group of patients. However, for this group of patients, the change would be significant either sparing them non-curative surgery or allowing aggressive management of oligometastatic disease. Therefore, we would recommend pre-operative brain imagin...

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“…In our cases series, 70% of patients died of primary cancer progression, and we had also reported previously the growth rate of metastatic brain tumor from NSCLC. The volume doubling time was about 3 months [ 22 23 ]. After resection of metastatic brain tumors, we usually followed up patients with brain MRI or CT every 3 months, and since most of the local or distant brain metastases appeared as small asymptomatic lesions, administration of radiation therapy after brain disease progression is discovered may also be effective.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Postoperative Chemotherapy for Patients with Metastatic Brain Tumors from Non-Small Cell Lung Cancer

Hong

Joo

Shin

et al. 2015

Brain Tumor Res Treat

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BackgroundThe purpose of this study is to evaluate the effect of postoperative chemotherapy on recurrence and survival in patients after resection of metastatic brain tumors from non-small cell lung cancers.MethodsPatients who went through resection of a single metastatic brain tumor from non-small cell lung cancer from July 2001 to December 2012 were reviewed. Those selected were 77 patients who survived more than 3 months after surgery were selected. Among them, 44 patients received various postoperative systemic chemotherapies, 33 patients received postoperative adjuvant whole brain radiotherapy (WBRT). Local/distant recurrence rate, local/distant recurrence free survival, disease free survival (DFS), and overall survival were compared between the two groups.ResultsAmong the 77 patients, there were 19 (24.7%) local recurrences. Local recurrence occurred in 7 (21.2%) of 33 patients in the adjuvant radiotherapy (RT) group and in 12 (27.3%) of the 44 patients in the chemotherapy group (p=0.542). Among the 77 patients, there were 34 (44.1%) distant recurrences. Distant recurrence occurred in 7 (21.2%) of the 33 patients in the adjuvant RT group and in 27 (61.4%) of the 44 patients in the chemotherapy group (p<0.0005). Patients' survival in terms of local recurrence free survival, distant recurrence free survival, DFS, and overall survival was not shown to be statistically different between the two groups before and after adjusting for covariates.ConclusionThere was no significant difference observed between postoperative adjuvant chemotherapy and adjuvant WBRT in terms of patients' survival. Postoperative chemotherapy is more feasible and may be an appropriate option for simultaneous control of both primary and metastatic lesions.

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Growth rates of metastatic brain tumors in nonsmall cell lung cancer

Cited by 18 publications

References 24 publications

Growth rate of newly developed metastatic brain tumors after thoracotomy in patients with non-small cell lung cancer

Growth rate of newly developed metastatic brain tumors after thoracotomy in patients with non-small cell lung cancer

Brain imaging before primary lung cancer resection: a controversial topic

The Efficacy of Postoperative Chemotherapy for Patients with Metastatic Brain Tumors from Non-Small Cell Lung Cancer

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