The effort to suppress the development of fusarium wilt disease is by a consortium of antagonistic microbes. This study aimed to determine the effect of microbial consortium and bulb size on the development of fusarium wilt disease and the effect on plant resistance of small bulbs to fusarium wilt. This research was conducted on coastal land, Sri Gading Village, Sanden District, Bantul Regency. The experiment used a split-plot with 2 factors : seed treatment and bulb size with 8 treatments. The factors include K1U1: Consortia microbial and small bulbs, K1U2: Consortia microbial and medium bulbs, K1U3: Consortia microbial and big bulbs, K1U4: Consortia microbial and mixed bulbs, K2U1: Without consortia microbial and small bulbs, K2U2: Without consortia microbial and medium bulbs, K2U3: Without consortia microbial and big bulbs, K2U4: Without consortia microbial and mixed bulbs. Data were analyzed statistically SAS (Statistical Analysis System) ANOVA 5% and further tested with DMRT (Duncan's Multiple Distance Test) at the 5% level of significance. The percentage data which is not normally distributed are transformed to transformation arcsin√x. The results showed there was no interaction between the use of microbial consortium and bulb size on the development of fusarium wilt disease and yield of shallot. The giving of consortium antagonists could not increase plant resistance to fusarium wilt and yield. The decline in production is generally related to climate change which has an impact on increasing plant diseases. There is a need for cultivation adaptation in dealing with the effects of climate change.