Growth Responses to Human Growth Hormone in Patients With Intrauterine Growth Retardation

Growth Hormone Treatment of Short Children Born Small for Gestational Age

“…In the pioneering studies attempting to normalize the short stature of children with insufficient catch-up growth, GH was administered with low frequency (4,5) or in substitution doses (6)(7)(8). The observed growth responses were heterogeneous and difficult to interpret.…”

Therapy with Growth Hormone – Old and New Indications

“…Disappointing results were also published by Grunt et al [62]. In contrast was the report of Foley et al [63] who achieved a doubling of the growth velocity in two thirds of their cases. Further favorable experiences were reported by Lanes et al [64], The explanation for these better outcomes lies in the GH dosis employed, 2 mg/m2 daily, i.e.…”

“…With conventional replace ment doses, Foley et al [63] and Soyka et al [65] did not achieve increased growth rates. Butenandt [48], who partly employed rather high doses did not obtain better results.…”

“…Butenandt [48], who partly employed rather high doses did not obtain better results. Remarkable exceptions are 3 patients with multi ple cartilaginous exostoses, observed by Foley et al [63], Martinez et al [66] and Bierich [67],…”

Plasma Somatomedin Activity and Urinary Hydroxyproline Excretion during Administration of Human Growth Hormone in Children with Short Stature

“…However, in many cases it is difficult to con clude if slow growth is the consequence of GH deficiency or if there are other mecha nisms involved. This is certainly the case in patients with borderline GH responses, but even at the extremes there are unexpected exceptions: some children with low GH re sponses show hardly any height acceleration on hGH therapy [Tanner et al, 1971], while others with normal GH responses accelerate their growth substantially [Grunt et al, 1972;Crawford et al, 1974;Escamilla, 1974;Foley et al, 1974;Wise et al, 1975;Trygstad, 1977;Kowarski et al, 1978;Rudman et al. 1981], If patients, in addition to their slow growth velocity and low GH secretion, have other features such as congenital abnormali ties or obesity, it becomes even more difficult to understand the pathophysiology of their growth failure.…”