Growth retardation in human cervical dysplasia-derived cell lines by beta-carotene through down-regulation of epidermal growth factor receptor

Muto, Yasutoshi; Fujii, Jun; Shidoji, Yoshihiro; Moriwaki, Hisataka; Kawaguchi, Tokuichi; Noda, Takahiro

doi:10.1093/ajcn/62.6.1535s

Cited by 70 publications

(20 citation statements)

References 14 publications

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“…Muto et al suggested that¯-carotene may prevent cervical carcinogenesis by inducing apoptosis in premalignant cervical dysplastic cells via down-regulation of epidermal growth factor receptor (32). We reported pro-apoptotic effects of canthaxanthin in both human colon adenocarcinoma and melanoma cells (33).…”

Section: Effects On Cell Proliferation Differentiation and Apoptosismentioning

confidence: 50%

Mitogenic and Apoptotic Signaling by Carotenoids: Involvement of a Redox Mechanism

Palozza

Serini²,

Nicuolo³

et al. 2001

IUBMB Life

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SummaryThe potential for carotenoids to modulate tumor growth is currently under investigation. Although epidemiological studies evidence that a high intake of vegetables, rich in carotenoids, decreases cancer incidence and mortality, clinical trials demonstrate that supplementation of¯-carotene to chronic smokers or to asbestos workers increases the risk for lung cancer. These contradictory ndings have renewed interest in elucidating the mechanism of action of carotenoids in biological systems. In this review, we show evidence for mitogenic and apoptotic effects of carotenoids and we support the hypothesis that these molecules may act as anticarcinogens or as procarcinogens through a redox mechanism. In particular, we report demonstrations for the anti-oxidant or pro-oxidant effects of carotenoids in vitro and in vivo, focusing our attention on the relationship existing between cell growth and redox status.

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Section: Effects On Cell Proliferation Differentiation and Apoptosismentioning

confidence: 50%

Mitogenic and Apoptotic Signaling by Carotenoids: Involvement of a Redox Mechanism

Palozza

Serini²,

Nicuolo³

et al. 2001

IUBMB Life

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“…Vitamin A, carotene or synthetic retinoids are capable of producing apoptosis in rat colonic tumor cells, 35 human prostate 36 and cervix, 37 and bovine mammary cells. 38 At least part of this effect may be mediated through the ability of the retinoids to block the effect of growth factors such as insulin-like growth factor-1 (IGF-1).…”

Section: Discussionmentioning

confidence: 99%

Carotenoids, antioxidants and ovarian cancer risk in pre- and postmenopausal women

Cramer¹,

Kuper²,

Harlow³

et al. 2001

Int. J. Cancer

106

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An inverse association between ovarian cancer risk, carotenoids and antioxidant vitamins has been suggested by several epidemiologic studies and 1 experimental trial of a vitamin A analogue. From a population-based study of 549 cases of ovarian cancer and 516 controls, we estimated the consumption of the antioxidant vitamins A, C, D and E and various carotenoids, including alpha-and beta-carotene and lycopene, using a validated dietary questionnaire. Multivariate logistic regression was used to calculate the exposure odds ratios adjusted for established ovarian cancer risk factors. Intakes of carotene, especially alpha-carotene, from food and supplements were significantly and inversely associated with risk for ovarian cancer, predominantly in postmenopausal women. Intake of lycopene was significantly and inversely associated with risk for ovarian cancer, predominantly in premenopausal women. Food items most strongly related to decreased risk for ovarian cancer were raw carrots and tomato sauce. Carotenoids include substances able to be converted into vitamin A, such as alpha-and beta-carotene, as well as other compounds, which cannot be converted into vitamin A but have more potent antioxidant properties, such as lycopene from tomatoes. Together with vitamins A, C and E, the carotenoids are believed to be important in cancer prevention because of their properties as antioxidants or their ability to affect cell differentiation or proliferation. Whether these substances affect risk for ovarian cancer is of interest given its high case-fatality ratio. Three case-control studies have reported that either beta-carotene or vitamin A might be inversely related to ovarian cancer risk. [1][2][3] In addition, an experimental trial to assess whether the vitamin A analogue, fenretinide, might prevent a second breast cancer yielded the surprising finding of a decreased risk for ovarian cancer. 4 In our report, we assessed the association between ovarian cancer and vitamins A, C, E and the carotenoids using data from a population-based case-control study. Taking the lead from an investigation of breast cancer suggesting that menopausal status might modify the association between carotenoids and breast cancer risk, 5 we examined whether menopausal status also influenced associations with ovarian cancer. MATERIAL AND METHODSThe parent study has been described previously. 6 Briefly, between May 1992 and March 1997, 1,080 incident cases of ovarian cancer among women residing in eastern Massachusetts or New Hampshire were identified through hospital tumor boards and statewide cancer registries. We excluded 203 of these cases because they had died (n ϭ 91), moved or had no phone (n ϭ 51), did not speak English (n ϭ 14) or had a nonovarian primary on review (n ϭ 47); 877 eligible women remained. Physicians denied access to 126 (14%) of these women, 136 (16%) declined to participate and 52 (6%) cases with nonepithelial tumors were excluded, leaving 563 cases with epithelial ovarian cancer, including tumors of borderline malignancy, ...

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“…In one of the earliest reports, b-carotene derived from Dunaliella was able to induce apoptosis in a preneoplastic cervical line, but not in a carcinoma-derived line (Muto et al, 1995;Toba et al, 1997). A differential effect of lutein on apoptotic pathways was reported for the MCF-7 mammary carcinoma cell line, SV40 transformed mammary cells, and normal human mammary cells.…”

Section: Growth Inhibitionmentioning

confidence: 97%

Carotenoid actions and their relation to health and disease

Krinsky

Johnson

2005

Molecular Aspects of Medicine

1,189

752

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Growth retardation in human cervical dysplasia-derived cell lines by beta-carotene through down-regulation of epidermal growth factor receptor

Cited by 70 publications

References 14 publications

Mitogenic and Apoptotic Signaling by Carotenoids: Involvement of a Redox Mechanism

Mitogenic and Apoptotic Signaling by Carotenoids: Involvement of a Redox Mechanism

Carotenoids, antioxidants and ovarian cancer risk in pre- and postmenopausal women

Carotenoid actions and their relation to health and disease

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