Growth retardation in pediatric inflammatory bowel diseases – pathogenesis and treatment

Pytrus, Tomasz; Iwańczak, Barbara

doi:10.5114/pg.2013.34833

Cited by 2 publications

(3 citation statements)

References 38 publications

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“…Some studies also suggested that IBD in infants follows a more severe course than in older patients, whereas other studies did not imply a similar poor prognosis [ 6 , 9 , 13 , 14 ]. Overall, the disease manifestations are primarily colonic and rapidly progress to pancolitis.…”

Section: Discussionmentioning

confidence: 99%

Demographic characteristics of children with early clinical manifestation of inflammatory bowel disease

Szymańska

Szczepański

et al. 2016

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IntroductionInflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is a chronic condition of the colon and small intestine. The disease is common in young people (children and young adults), but it is rare in children younger than five years of age. Therefore, IBD developing during the first years of life (under the age of 5) is known as an early-onset IBD (EO-IBD), and it is considered to be a specific entity with a distinct phenotype. However, the available data on that issue are still insufficient.AimTo determine the characteristics and clinical course of children with early-onset IBD.Material and methodsWe performed a retrospective database analysis of 47 infants younger than 5 years old diagnosed with IBD. Patient's demographic data, including age, sex, and age at disease onset, were collected in 6 paediatric hospitals in Poland. Disease location was established on the basis of the review of all endoscopic, colonoscopic, histopathological, and radiological records. All possible complications were reported, as well as any treatment and its efficacy. Since the diagnosis was established all patients have been on follow up.ResultsAmong 47 children registered in the database, 23 (49%) had a diagnosis of CD, 16 (34%) had UC, and 8 (17%) had IC (indeterminate colitis). The mean age at diagnosis was 28.5 ±27.5 months; 57.4% were male. The most common location/type of disease was ileocolonic disease (L3). The most common complication of IBD was anaemia, found in 30 (63.8%) children. The observed course of the disease was either severe or moderate. In 4 children younger than 2 years old, surgery was performed.ConclusionsInflammatory bowel disease in children younger than 5 years old includes UC, CD, and a relatively high proportion of IC. In early-onset IBD severe and moderate course of the disease is usually observed. Disease manifestation in these patients is predominantly ileocolonic.

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Section: Discussionmentioning

confidence: 99%

Demographic characteristics of children with early clinical manifestation of inflammatory bowel disease

Szymańska

Szczepański

et al. 2016

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“…Diffuse alveolar hemorrhage has been described after infusion of infliximab in patients with CD [ 122 ]. The number of reports on infliximab-induced lung complications may be growing, with the increasing acceptance of this therapeutic option for the treatment of IBD [ 123 ]. In the context of both UC and CD, non-specific interstitial pneumonia (NSIP) was described recently [ 124 , 125 ].…”

Section: Drug-related Lung Pathology In Inflammatory Bowel Disease Pamentioning

confidence: 99%

“…This interaction is crucial for a control response to infection at the intestinal mucosa and to regulate autophagy [ 136 ]. The defective polymorphic variant (R702W) occurs in about 15% of CD patients, and is a risk factor of a more severe course [ 123 ]. The same functional polymorphic variant was linked to severe chronic sarcoidosis [ 138 ].…”

Section: Possible Links Between Bowel and Lung Diseasementioning

confidence: 99%

Pulmonary manifestations of inflammatory bowel disease

Majewski¹,

Piotrowski²

2015

aoms

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Bronchopulmonary signs and symptoms are examples of variable extraintestinal manifestations of the inflammatory bowel diseases (IBD). These complications of Crohn's disease (CD) and ulcerative colitis (UC) seem to be underrecognized by both pulmonary physicians and gastroenterologists. The objective of the present review was to gather and summarize information on this particular matter, on the basis of available up-to-date literature. Tracheobronchial involvement is the most prevalent respiratory presentation, whereas IBD-related interstitial lung disease is less frequent. Latent and asymptomatic pulmonary involvement is not unusual. Differential diagnosis should always consider infections (mainly tuberculosis) and drug-induced lung pathology. The common link between intestinal disease and lung pathology is unknown, but many hypotheses have been proposed. It is speculated that environmental pollution, common immunological mechanisms and predisposing genetic factors may play a role.

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Growth retardation in pediatric inflammatory bowel diseases – pathogenesis and treatment

Cited by 2 publications

References 38 publications

Demographic characteristics of children with early clinical manifestation of inflammatory bowel disease

Demographic characteristics of children with early clinical manifestation of inflammatory bowel disease

Pulmonary manifestations of inflammatory bowel disease

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