BackgroundThere is an association between overweight status and life span in kenneled dogs, but a similar association has not been reported for pet dogs.ObjectivesTo examine the effects of being overweight in middle age on the life span of neutered clientâowned dogs.AnimalsFiftyâthousand sevenâhundred eighty seven middleâaged neutered clientâowned dogs attending a network of approximately 900 veterinary hospitals across North America.MethodsRetrospective caseâcontrol study. For each of 12 breeds, groups of dogs aged between 6.5 and 8.5 years were identified as being in âoverweightâ or ânormalâ body condition. Within each breed and sex, differences in life span between dogs in normal body condition and overweight body condition in the 2 groups were then analyzed by Cox proportional hazards models.ResultsFor all breeds, instantaneous risk of death for dogs in overweight body condition was greater than those in normal body condition throughout the age range studied, with hazard ratios ranging from 1.35 (99.79% confidence interval [CI] 1.05â1.73) for German Shepherd dog to 2.86 (99.79% CI 2.14â3.83) for Yorkshire Terrier. In all breeds, median life span was shorter in overweight compared with normal weight dogs, with the difference being greatest in Yorkshire Terriers (overweight: 13.7âyears, 99.79% CI 13.3â14.2; normal: 16.2âyears, 99.79% CI 15.7â16.5) and least in German Shepherd dogs (overweight: 12.1âyears, 99.79% CI 11.8â12.4; normal: 12.5âyears, 99.79% CI 12.2â12.9).Conclusions and Clinical ImportanceVeterinary professionals should consider promoting healthy body condition for dogs, particularly from midlife onward.