2003
DOI: 10.1016/s0006-3495(03)70018-6
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Growth Velocities of Branched Actin Networks

Abstract: The growth of an actin network against an obstacle that stimulates branching locally is studied using several variants of a kinetic rate model based on the orientation-dependent number density of filaments. The model emphasizes the effects of branching and capping on the density of free filament ends. The variants differ in their treatment of side versus end branching and dimensionality, and assume that new branches are generated by existing branches (autocatalytic behavior) or independently of existing branch… Show more

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Cited by 130 publications
(166 citation statements)
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References 38 publications
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“…These include the thermal ratchet model for polymerization-dependent force Oster, 1996a,b, 2003), filament side-branching (Carlsson, 2001(Carlsson, , 2003, and filament-turnover (Mogilner and EdelsteinKeshet, 2002;Grimm et al, 2003). An overarching recent objective has been to start combining diverse aspects of cell motility into a framework of a spatial cell.…”
Section: Discussionmentioning
confidence: 99%
“…These include the thermal ratchet model for polymerization-dependent force Oster, 1996a,b, 2003), filament side-branching (Carlsson, 2001(Carlsson, , 2003, and filament-turnover (Mogilner and EdelsteinKeshet, 2002;Grimm et al, 2003). An overarching recent objective has been to start combining diverse aspects of cell motility into a framework of a spatial cell.…”
Section: Discussionmentioning
confidence: 99%
“…In the case of L. monocytogenes, it is an important feature because these bacteria have to cross cell membranes to disseminate: they must keep moving against the force exerted by these obstacles. Various force-velocity relations have been predicted by different theoretical models of actin-based propulsion (30,(34)(35)(36)) (see ref. 37 for review).…”
Section: Discussionmentioning
confidence: 99%
“…Directionally biased branching has important implications for branched actin assembly in vivo, where autocatalytic nucleation amplifies small effects (26,42). A large fraction of filaments in a branched actin network adopt an approximately −35°orientation (43), and the side of a bent filament experiencing extensional strain is the same side that typically faces the bending force.…”
Section: A Fluctuation Gating Model For Branching By the Arp2/3 Complmentioning
confidence: 99%