Growth Velocity of Some Fetal Parameters

Guihard-Costa, Anne-Marie; Larroche, Jeanne‐Claudie

doi:10.1159/000243887

Cited by 31 publications

(9 citation statements)

References 7 publications

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“…This is comparable with previous MR volumetric studies, performed on 3D reconstructed data within smaller gestational age ranges, which presented growth ranges of 10.22–17% (Clouchoux et al 2011; Rajagopalan et al 2011; Scott et al 2011). The volume range increased from around 30 weeks of gestation suggesting that individual variation starts to arise and becomes greater with progressing age as previously shown (Guihard-Costa and Larroche 1992; Scott et al 2011; Snijders and Nicolaides 1994). Cortical volume increased at a relative growth rate of 14.78% per week in our sub-cohort of fetuses.…”

Section: D Volumetric Measurementssupporting

confidence: 75%

“…The supratentorial brain tissue followed a quadratic growth pattern indicating accelerated growth at this stage of development as demonstrated by the increasing growth velocity in brain weight in the third trimester (Guihard-Costa and Larroche 1992). The absolute volume increased between 22 and 38 weeks at a relative growth rate of 13.04% per week.…”

Section: D Volumetric Measurementsmentioning

confidence: 96%

“…The relative growth rate of the cerebellum exceeded that of the supratentorial brain tissue as previously shown in post-mortem and MR studies (Clouchoux et al 2011; Grossman et al 2006; Hatab et al 2008; Limperopoulos et al 2010; Vatansever et al 2013). The cerebellum exhibits an abrupt acceleration in growth velocity from 24 weeks of gestation in comparison with the supratentorial brain and maintains this acceleration until birth (Guihard-Costa and Larroche 1992; Moss and Noback 1956). Cerebellar volume related to supratentorial brain tissue volume by a scaling exponent of 1.25.…”

Section: D Volumetric Measurementsmentioning

confidence: 99%

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Normative biometry of the fetal brain using magnetic resonance imaging

et al. 2016

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The fetal brain shows accelerated growth in the latter half of gestation, and these changes can be captured by 2D and 3D biometry measurements. The aim of this study was to quantify brain growth in normal fetuses using Magnetic Resonance Imaging (MRI) and to produce reference biometry data and a freely available centile calculator (https://www.developingbrain.co.uk/fetalcentiles/). A total of 127 MRI examinations (1.5 T) of fetuses with a normal brain appearance (21–38 gestational weeks) were included in this study. 2D and 3D biometric parameters were measured from slice-to-volume reconstructed images, including 3D measurements of supratentorial brain tissue, lateral ventricles, cortex, cerebellum and extra-cerebral CSF and 2D measurements of brain biparietal diameter and fronto-occipital length, skull biparietal diameter and occipitofrontal diameter, head circumference, transverse cerebellar diameter, extra-cerebral CSF, ventricular atrial diameter, and vermis height, width, and area. Centiles were constructed for each measurement. All participants were invited for developmental follow-up. All 2D and 3D measurements, except for atrial diameter, showed a significant positive correlation with gestational age. There was a sex effect on left and total lateral ventricular volumes and the degree of ventricular asymmetry. The 5th, 50th, and 95th centiles and a centile calculator were produced. Developmental follow-up was available for 73.1% of cases [mean chronological age 27.4 (±10.2) months]. We present normative reference charts for fetal brain MRI biometry at 21–38 gestational weeks. Developing growth trajectories will aid in the better understanding of normal fetal brain growth and subsequently of deviations from typical development in high-risk pregnancies or following premature delivery.Electronic supplementary materialThe online version of this article (doi:10.1007/s00429-016-1342-6) contains supplementary material, which is available to authorized users.

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Section: D Volumetric Measurementssupporting

confidence: 75%

Section: D Volumetric Measurementsmentioning

confidence: 96%

Section: D Volumetric Measurementsmentioning

confidence: 99%

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Normative biometry of the fetal brain using magnetic resonance imaging

et al. 2016

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“…3D ultrasonography [14, 31] estimated an accelerating trajectory through 20 to 30 GW, as was shown in the present study. Further, a study of brain weight found that growth velocity of the infratentorial part of the brain (including the cerebellum) increased between 20 and 35 GW, after which the rate plateaued until term [4]. …”

Section: Discussionmentioning

confidence: 99%

“…In the later half of gestation, the human brain grows and increases in structural complexity at a more rapid rate than in any other period of development [1–4]. The cerebellar cortex is undergoing extensive foliation leading to accelerating increases in surface area [5, 6].…”

Section: Introductionmentioning

confidence: 99%

3D Morphometric Analysis of Human Fetal Cerebellar Development

et al. 2011

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To date, growth of the human fetal cerebellum has been estimated primarily from linear measurements from ultrasound and 2D magnetic resonance imaging (MRI). In this study, we use 3D analytical methods to develop normative growth trajectories for the cerebellum in utero. We measured cerebellar volume, linear dimensions, and local surface curvature from 3D reconstructed MRI of the human fetal brain (N = 46). We found that cerebellar volume increased approximately 7-fold from 20 to 31 gestational weeks. The better fit of the exponential curve (R2 = 0.96) compared to the linear curve (R2 = 0.92) indicated acceleration in growth. Within-subject cerebellar and cerebral volumes were highly correlated (R2 = 0.94), though the cerebellar percentage of total brain volume increased from approximately 2.4% to 3.7% (R2 = 0.63). Right and left hemispheric volumes did not significantly differ. Transcerebellar diameter, vermal height, and vermal anterior to posterior diameter increased significantly at constant rates. From the local curvature analysis, we found that expansion along the inferior and superior aspects of the hemispheres resulted in decreased convexity, which is likely due to the physical constraints of the dura surrounding the cerebellum and the adjacent brainstem. The paired decrease in convexity along the inferior vermis and increased convexity of the medial hemisphere represents development of the paravermian fissure, which becomes more visible during this period. In this 3D morphometric analysis of the human fetal cerebellum, we have shown that cerebellar growth is accelerating at a greater pace than the cerebrum and described how cerebellar growth impacts the shape of the structure.

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The timing hypothesis and body proportionality of the intra-uterine growth retarded infant

1999

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Intra‐uterine growth retardation (IUGR) is a heterogeneous designation, as seen in the fact that neonatal morbidity and mortality differ for IUGR infants that are disproportionate vs proportionate based on the ponderal index (weight/height3). Much less is known, however, concerning the etiology of these two forms. This study tests the hypothesis that the form of IUGR (proportionate vs disproportionate) is related to the timing of stress during gestation, specifically, that linear growth is compromised by second trimester stress and the ponderal index is compromised by third trimester stress. This hypothesis is tested using data on 755 full‐term mother‐infant pairs studied prospectively in rural northern Malawi where the seasonal stress of the pre‐harvest rainy season (PHRS) is a regular occurrence. The results indicate that exposure to PHRS in the second trimester is not associated with weight, length, or the ponderal index at birth. Exposure to PHRS in the third trimester is associated with diminished birth weight and length, but not ponderal index. The results do not support the timing hypothesis, at least as previously framed in the literature, and suggest the possibility that linear growth may precede or be more sensitive to prenatal stress than the ponderal index. Am. J. Hum. Biol. 11:638–646, 1999. © 1999 Wiley‐Liss, Inc.

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Growth Velocity of Some Fetal Parameters

Cited by 31 publications

References 7 publications

Normative biometry of the fetal brain using magnetic resonance imaging

Normative biometry of the fetal brain using magnetic resonance imaging

3D Morphometric Analysis of Human Fetal Cerebellar Development

The timing hypothesis and body proportionality of the intra-uterine growth retarded infant

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