GRP78 and next generation cancer hallmarks: An underexplored molecular target in cancer chemoprevention research

Madhavan, Shenbagam; Sangeetha, N.

doi:10.1016/j.biochi.2020.05.005

Cited by 23 publications

(14 citation statements)

References 61 publications

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“…ER oxidative stress but translocation of this protein to the membrane also aims to meet the increased demand for glucose inside the infected and stressed cell, since GRP78 contributes to increased glucose uptake into cells (Madhavan and Nagarajan, 2020). In fact, elevated GRP78 levels are significantly higher in COVID-19 infected patients with or without pneumonia than in healthy controls and also tend to be higher than in COVID-negative patients with pneumonia (Sabirli et al, 2021).…”

Section: Increased Glucose Consumption By Cells In Sars-cov-2 Infectionmentioning

confidence: 99%

Changes in Glycolytic Pathway in SARS-COV 2 Infection and Their Importance in Understanding the Severity of COVID-19

et al. 2021

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COVID-19 is an infectious disease caused by Coronavirus 2 (SARS-CoV-2) that may lead to a severe acute respiratory syndrome. Such syndrome is thought to be related, at least in part, to a dysregulation of the immune system which involves three main components: hyperactivity of the innate immune system; decreased production of type 1 Interferons (IFN) by SARS-CoV-2-infected cells, namely respiratory epithelial cells and macrophages; and decreased numbers of both CD4+ and particularly CD8+ T cells. Herein, we describe how excessive activation of the innate immune system and the need for viral replication in several cells of the infected organism promote significant alterations in cells’ energy metabolism (glucose metabolism), which may underlie the poor prognosis of the disease in severe situations. When activated, cells of the innate immune system reprogram their metabolism, and increase glucose uptake to ensure secretion of pro-inflammatory cytokines. Changes in glucose metabolism are also observed in pulmonary epithelial cells, contributing to dysregulation of cytokine synthesis and inflammation of the pulmonary epithelium. Controlling hyperglycolysis in critically ill patients may help to reduce the exaggerated production of pro-inflammatory cytokines and optimise the actions of the adaptive immune system. In this review, we suggest that the administration of non-toxic concentrations of 2-deoxy-D-glucose, the use of GLUT 1 inhibitors, of antioxidants such as vitamin C in high doses, as well as the administration of N-acetylcysteine in high doses, may be useful complementary therapeutic strategies for these patients, as suggested by some clinical trials and/ or reports. Overall, understanding changes in the glycolytic pathway associated with COVID-19 infection can help to find new forms of treatment for this disease.

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Section: Increased Glucose Consumption By Cells In Sars-cov-2 Infectionmentioning

confidence: 99%

Changes in Glycolytic Pathway in SARS-COV 2 Infection and Their Importance in Understanding the Severity of COVID-19

et al. 2021

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“…Reprogramming metabolism is an important feature of cancer pathogenesis. 114 Cancer cells activate or inhibit metabolic pathways such as aerobic glycolysis (also known as the Warburg effect), 115 disordered lipid metabolism, 116 and glutamine-dependent anaplerosis to accelerate cell proliferation. 117 Recent studies report that m 6 A modification plays an important role in regulation of metabolic reprogramming of cancer.…”

Section: Role Of M 6 a Modification In Cancer Metabolic Reprogramingmentioning

confidence: 99%

Regulatory role and mechanism of m6A RNA modification in human metabolic diseases

Zhang¹,

Chen²,

Zheng³

et al. 2021

Molecular Therapy - Oncolytics

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Metabolic diseases caused by disorders in amino acids, glucose, lipid metabolism, and other metabolic risk factors show high incidences in young people, and current treatments are ineffective. N 6 -methyladenosine (m 6 A) RNA modification is a posttranscriptional regulation of gene expression with several effects on physiological processes and biological functions. Recent studies report that m 6 A RNA modification is involved in various metabolic pathways and development of common metabolic diseases, making it a potential disease-specific therapeutic target. This review explores components, mechanisms, and research methods of m 6 A RNA modification. In addition, we summarize the progress of research on m 6 A RNA modification in metabolism-related human diseases, including diabetes, obesity, non-alcoholic fatty liver disease, osteoporosis, and cancer. Furthermore, opportunities and the challenges facing basic research and clinical application of m 6 A RNA modification in metabolism-related human diseases are discussed. This review is meant to enhance our understanding of the molecular mechanisms, research methods, and clinical significance of m 6 A RNA modification in metabolism-related human diseases.

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“…Tumour‐immune cells interaction is a significant territory of research in regard to prognosis in CRC. Cancer accelerating inflammation orchestrates a strong immune cell response and the tumour microenvironment (TME) are arising as crucial obstacles to the development of effective therapies 6,7 . Specifically, tumour‐associated macrophages (TAMs) are dominating immune cells in the TME and have been implicated in neoplastic progression, survival and metastatic dissemination in various solid tumours 8,9 .…”

Section: Introductionmentioning

confidence: 99%

“…Cancer accelerating inflammation orchestrates a strong immune cell response and the tumour microenvironment (TME) are arising as crucial obstacles to the development of effective therapies. 6 , 7 Specifically, tumour‐associated macrophages (TAMs) are dominating immune cells in the TME and have been implicated in neoplastic progression, survival and metastatic dissemination in various solid tumours. 8 , 9 Meanwhile, TAMs also play a pivotal role in influencing the tumour activity and prognosis of CRC.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value and predictive biomarkers of phenotypes of tumour‐associated macrophages in colorectal cancer

Sun

Yang

et al. 2022

Scand J Immunol

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Background The roles of different subtypes of tumour‐associated macrophages (TAMs) in predicting the prognosis of colorectal cancer (CRC) remain controversial. In this study, different subtypes of TAMs were investigated as prognostic and predictive biomarkers for CRC. Methods Expressions of CD68, CD86 and CD163 were investigated by immunohistochemistry (IHC) and immunofluorescence (IF), and the correlation between the expression of CD86 and CD163 was calculated in colorectal cancer tissues from 64 CRC patients. Results The results showed that high expressions of CD86+ and CD68+CD86+ TAMs as well as low expression of CD163+ and CD68+CD163+ TAMs were significantly associated with favourable overall survival (OS). The level of CD86 protein expression showed a negative correlation with CD163 protein expression. In addition, CD86 protein expression remarkably negatively correlated with tumour differentiation and tumour node metastasis (TNM) stage, while CD163 protein expression significantly positively correlated with tumour differentiation and tumour size. As an independent risk factor, high expression of CD86 TAMs had prominently favourable prognostic efficacy, while high expression of CD68+CD163+ TAMs had significantly poor prognostic efficacy. Conclusions These results indicate that CD86+ and CD68+CD163+ TAMs as prognostic and predictive biomarkers for CRC.

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GRP78 and next generation cancer hallmarks: An underexplored molecular target in cancer chemoprevention research

Cited by 23 publications

References 61 publications

Changes in Glycolytic Pathway in SARS-COV 2 Infection and Their Importance in Understanding the Severity of COVID-19

Changes in Glycolytic Pathway in SARS-COV 2 Infection and Their Importance in Understanding the Severity of COVID-19

Regulatory role and mechanism of m6A RNA modification in human metabolic diseases

Prognostic value and predictive biomarkers of phenotypes of tumour‐associated macrophages in colorectal cancer

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