Grupo sanguíneo PI y su relación con cicatriz renal en Pacientes con infección urinaria.

Abstract

Renal scars and P blood subgroup Possible relationships between renal scars and P blood group have been 'ecently emphasized. Urinary tract infections, an important factor in the production of renal scar, are mainly caused by specific types of E. coll, which has the ability to adhere through fimbriae, to receptors of the urinary tract epithelium that are structurally related to antigens detected in people with blood group P1. We looked for Pi subgroup in 30 children with vesicourete r a5 reflux and rena! scar and 30 patients with equivalent degrees of reflux but without evidence of renal scar. Sex and age were unmatched. Thefrequency of PI blood subgroup was similar in both kinds of patients (56.7% vs. 66.7, n.s.) so we could not demonstrate that P1 subgroup can be a useful Indirect risk marker for rena' scar formation.

Genetic markers and acute febrile urinary tract infection in the 1st year of life

“…E. coli with P-fimbriae would then attach to these receptors, rendering these individuals more susceptible to urinary infection by this microorganism [17]. Other investigators [7,9,11,12], however were unable to confirm this association, and another group [6] observed a significant excess of the P2 phenotype. Associations were also observed in the ABO system (excess of A and lack of O among patients) [13], MN (deficiency of MN) [8], Rh (excess of Rh-) [11], Lewis (excess of Le (a-b-)) [9,16], ABH secretion (excess of non-secretors) [14], and HLA (excess of A2 and A3, lack of A10, B5, BW16, BW35) [1,4], although in the latter case the significance disappeared after correction for the number of comparisons performed.…”