The traditional power system relay protection technology in high altitude areas is more inefficient. This paper analyzes the main sources of interference of relay protection equipment in high altitude areas and proposes a targeted strategy to improve the anti-interference technology of relay protection. The mathematical model of relay protection failure is established, and the support vector machine algorithm model is used to realize the construction of the relay protection state algorithm model so that the macro data in the operation process of relay protection equipment is converted into microdata, which improves the management ability of relay protection equipment. Subsequently, the mathematical model of anti-interference calculation of relay protection devices is used to process the collected interference signals, eliminate the interference signals after accurate identification, and improve the anti-interference ability of relay protection equipment. The relay protection device undergoes testing after the construction of the relay protection state algorithm model and anti-interference calculation model. The experimental results show that the equipment failure rate under the relay protection state algorithm is less than 0.8%, the annual failure rate of equipment components is less than 0.2%, and the overall analog output error rate amplitude is only half of that under the original anti-jamming technology when adopting the mathematical model of anti-jamming calculation of relay protection device, which proves that the anti-jamming ability enhancement strategy proposed in this paper is capable of reducing the relay protection in high-altitude areas caused by false and refusal to act. Equipment losses in high altitude areas.