2021
DOI: 10.1002/adfm.202102160
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GSH‐Depleted Nanozymes with Dual‐Radicals Enzyme Activities for Tumor Synergic Therapy

Abstract: Although inspiring progress has been achieved in tumor nanocatalytic therapies based on tailor‐made nanozymes for converting hydrogen peroxide into reactive oxygen species (ROS) efficiently, most cytotoxic hydroxyl radicals do not spread far enough within a cell to damage the primary organelles for effective tumor therapy due to their short half‐life time (≈1 µs). Developing a novel nanocatalyst platform involving longer half‐life time ROS is desired. To this end, Fe3O4‐Schwertmannite nanocomposites (Fe3O4‐Sch… Show more

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Cited by 46 publications
(39 citation statements)
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“…Therefore, combination therapy involving additional therapeutics is necessary. [ 23–28 ] This however complicates fabrication, encapsulation, delivery, and release processes, making it not practical due to poor reproducibility, reduced effectiveness, high side‐effects, and high cost.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Therefore, combination therapy involving additional therapeutics is necessary. [ 23–28 ] This however complicates fabrication, encapsulation, delivery, and release processes, making it not practical due to poor reproducibility, reduced effectiveness, high side‐effects, and high cost.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, combination therapy involving additional therapeutics is necessary. [23][24][25][26][27][28] This however complicates fabrication, encapsulation, delivery, and release processes, making it not practical Catalytic cancer therapy based on nanozymes has recently attracted much interest. However, the types of the current nanozymes are limited and their efficiency is usually compromised and not sustainable in the tumor microenvironment (TME).…”
mentioning
confidence: 99%
“…However, the extremely short half-life (∼1 µs) of •OH restricts its future application. This problem was addressed by constructing Fe 3 O 4 nanocrystals coated with Schwertmannite (Sch) matrix (Sch@Fe 3 O 4 ), which possessed the ability to generate SO 4 • - radicals from SO 4 2- when attacked by •OH radicals in a cascade reaction ( Wu et al, 2021 ). Fe 3 O 4 hollow core generates •OH in Fenton’s reaction, which is converted to SO 4 •- (half-life of ∼30 µs) by nanoscale cellular pseudopodia-shaped Sch grown on the Fe 3 O 4 core.…”
Section: Research Progress In Ros-mediated Therapeutic Applications O...mentioning
confidence: 99%
“…This inhibition leads to a dilemma on the use of multimodal therapy, which has already demonstrated a superadditive effect for cancer treatment. [ 12–20 ] Currently, stunning GSH depletion strategies that are used in combination with cancer therapy are mainly focused on the direct elimination of GSH [ 4,21–28 ] or on the elimination of its upstream molecules, such as L‐cysteine, which are required for the synthesis of GSH. [ 1,29 ] Various enzyme inhibitors efficiently block the generation of intracellular GSH.…”
Section: Introductionmentioning
confidence: 99%
“…This inhibition leads to a dilemma on the use of multimodal therapy, which has already demonstrated a superadditive effect for cancer treatment. [12][13][14][15][16][17][18][19][20] Currently, stunning GSH depletion strategies that are used in combination with cancer therapy are mainly focused on the direct elimination of GSH [4,[21][22][23][24][25][26][27][28] or on the elimination of its upstream molecules, such as L-cysteine, which are required for the synthesis of GSH. [1,29] Various enzyme inhibitors efficiently block Excessive glutathione (GSH), which is produced owing to abnormal metabolism of tumor cells, scavenges photo-induced reactive oxygen species (ROS) and consumes chemotherapeutic drugs, thereby attenuating the efficacy of photodynamic therapy and chemotherapy, respectively.…”
mentioning
confidence: 99%