GST null polymorphisms may affect the risk of coronary artery disease: evidence from a meta-analysis

Abstract

Background: Whether glutathione S-transferase (GST) null polymorphisms, namely GSTM1 null, GSTP1 null and GSTT1 null polymorphisms, influence the risk of coronary artery disease (CAD) or not remains unclear. Thus, the authors performed a meta-analysis to more robustly estimate associations between GST null polymorphisms and the risk of CAD by integrating the results of previous publications. Methods: Medline, Embase, Wanfang, VIP and CNKI were searched comprehensively for eligible studies, and 45 genetic association studies were finally selected to be included in this meta-analysis. Results: We found that GSTM1 null polymorphism was significantly associated with the risk of CAD in overall population (OR = 1.37, p = 0.003) and mixed population (OR = 1.61, p = 0.004), GSTP1 null polymorphism was significantly associated with the risk of CAD in overall population (OR = 1.23, p = 0.03), whereas GSTT1 null polymorphism was significantly associated with the risk of CAD in overall population (OR = 1.23, p = 0.02), Caucasians (OR = 1.23, p = 0.02) and East Asians (OR = 1.38, p < 0.0001). Conclusions: This meta-analysis demonstrated that GSTM1 null, GSTP1 null and GSTT1 null polymorphisms were all significantly associated with an increased risk of CAD.

Genetic variants of PON1, GSTM1, GSTT1, and locus 9p21.3, and the risk for premature coronary artery disease in Yucatan, Mexico

“…We focused on genetic variants of candidate genes which have been associated with the pathogenesis of coronary atherosclerosis. They, play key roles in the inactivation of pro‐oxidants and pro‐inflammatory mediators, lipid and xenobiotic metabolism, detoxification of reactive oxygen species, and regulation of cellular proliferation during the development of atherosclerosis (Almontashiri, 2017; Bhattacharyya et al, 2008; Su et al, 2020). These variants occur in Paraoxonase 1 ( PON1 , OMIM 168820), Glutathione S‐transferase M1 ( GSTM1 , OMIM 138350), Glutathione S‐transferase T1 ( GSTT1 , OMIM 600436), and a 58‐kb interval on chromosome 9p21.3 (OMIM 611139).…”

“…Epidemiological studies have indicated that the GSTM1 and GSTT1 null variants are associated with an increased risk of CAD, especially when several other factors, such as diabetes mellitus, hypertension, and cigarette smoking, are present (Grubisa et al, 2018; Kariž et al, 2012; Kim et al, 2008; Mir et al, 2016; Tamer et al, 2004). Likewise, the GSTM1 null genotype has been associated with the risk of CAD from a meta‐analysis in Caucasians, Asians, and mixed populations, whereas the GSTT1 null polymorphism was significantly associated with the risk of CAD in the overall population, Caucasians and East Asians (Su et al, 2020). In addition, the combined GSTM1/T1 null genotypes have been associated with the susceptibility to the development of CAD (Grubisa et al, 2018; Kim et al, 2008; Zhang & Zhang, 2014).…”

Association of GSTP1 Ile105Val polymorphism with the risk of coronary heart disease: An updated meta-analysis

“…Recently, one previous meta-analysis, conducted by Su et al [24], included 4,595 cases and 4,390 controls from 11 studies. They proved that GSTP1 null polymorphism was associated with the risk of CHD in the overall population (OR, 1.23; 95% CI, 1.02 to 1.48).…”

“…A number of case-control studies [4,7,8,[12][13][14][15][16][17][18][19][20][21][22][23] have investigated the relationship between GSTP1 Ile105Val polymorphism with the risk of CHD, with equivocal conclusions. Recently, one meta-analysis [24] revealed that a significant association exists between GSTP1 null genotype and CHD, and the other one [25] suggested that GSTP1 null genotype could impact individual susceptibility to atherosclerotic cardiovascular diseases. However, numerous relevant publications [4, 19,22,23] did not appear in their meta-analyses.…”

Variabilidade do número de cópias de GSTM1 e de GSTT1 no câncer oral: risco e evolução

“…Além da frequência dos genótipos nulos, a análise da presença/ausência de GSTM1 e de GSTT1 também foi empregada em investigações sobre a susceptibilidade de diferentes doenças como asma (Li et al, 2013), diabetes mellitus (Zhang et al, 2013a;Nath et al, 2019), doenças arteriais e coronarianas (Zhou et al, 2014;Grubisa et al, 2018;Su et al, 2020), hipertensão (Ge et al, 2015) e diferentes tipos tumorais (Sampaio et al, 2009). Dentre os resultados, foi demonstrada que os genótipos nulos de GSTM1 e de GSTT1 foram associados, de forma individual, ou em combinação entre si, com o aumento do risco de diabetes mellitus (Zhang et al, 2013;Nath et al, 2019) e de distúrbios arteriais (Grubisa et al, 2018).…”