2007
DOI: 10.1016/j.mrfmmm.2007.02.014
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GSTM1, GSTT1 and CYP1A1 detoxification gene polymorphisms and susceptibility to smoking-related coronary artery disease: A case-only study

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Cited by 63 publications
(52 citation statements)
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“…Another study conducted in Brazil showed that the prevalence of GSTT1-null genotype was higher in patients from the city of Vitória subjected to coronary angiography (Maciel et al, 2009). Manfredi et al (2007) also identified the prevalence of the null GSTT1 genotype associated with a three times greater risk for the development of coronary artery disease in patients with type II diabetes and smokers from Italy showing a large vessel obstruction.…”
Section: Discussionmentioning
confidence: 93%
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“…Another study conducted in Brazil showed that the prevalence of GSTT1-null genotype was higher in patients from the city of Vitória subjected to coronary angiography (Maciel et al, 2009). Manfredi et al (2007) also identified the prevalence of the null GSTT1 genotype associated with a three times greater risk for the development of coronary artery disease in patients with type II diabetes and smokers from Italy showing a large vessel obstruction.…”
Section: Discussionmentioning
confidence: 93%
“…Marinković et al (2013) highlight the importance of genetic polymorphisms involved in the biotransformation and atherosclerosis to better study the expression of the gene and then elucidate their interaction to the environment. Several studies have been related to the polymorphism of GSTT1 in patients with atherosclerosis (Hayek et al, 2006;Manfredi et al, 2007;Maciel et al, 2009;Bazo et al, 2011;Taspinar et al, 2012).…”
Section: Discussionmentioning
confidence: 99%
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“…GSTM1 and GSTT1 polymorphisms, however, were not significantly associated with lipid parameters (25). In Italy, Manfredi et al (26) found no significant differences in CYP1A1 genotypes frequencies between smokers with CAD and without CAD, but did establish a significant association between combined GSTM1 (null) plus GSTT1(null) genotypes and CAD risk. In Turkey, a significant CAD risk was established in the carriers of the CYP1A1 variant plus GSTT1 null genotype (27).…”
Section: Discussionmentioning
confidence: 95%
“…Furthermore, a potential modification by smoking status has been suggested but not addressed in studies with sufficient power. 11,12,17,18,20,22,24,25,27,30,32 Consequently, large studies with sufficient power to determine main as well as interaction effects of exact copy numbers of GSTM1 and GSTT1 are needed.We examined the hypothesis that CNV in GSTM1 or GSTT1 associates with risk of ischemic heart disease (IHD), myocardial infarction (MI), ischemic cerebrovascular disease (ICVD), ischemic stroke (IS), or any ischemic vascular event and that GST genotype interacts with smoking exposure on disease end points. Similar hypotheses also were tested for 2 functional genetic variants in GSTP1, I105V (rs1695) and A114V (rs1138272).…”
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confidence: 99%