GSTM1 null genotype as risk factor for late-onset Alzheimer's disease in Italian patients

Glutathione S-transferase genes and the risk of recurrent miscarriage in Italian women

“…A number of studies have highlighted that functional genetic variants in cytosolic GST genes have health implications related to the oxidative stress susceptibility and are associated with an increased risk of different multifactorial diseases (13)(14)(15). However, the genetic association between GST variant and disease risk is strongly affected by environmental conditions and ethnicity of the study populations (16).…”

Glutathione S-transferases variants as risk factors in Alzheimer’s disease

“…Moreover, other GSTs genes, e.g., GSTA1, GSTO2, may also play a role in the development of Alzheimer's disease. One research [18] suggested that GSTA1 rs3957356 was associated with the increased AD in Dominant model. Positive effect of rs156697 on GSTO2 was also found [32] among older ([80 years old) AD patients.…”

“…13 documents were excluded because of insufficient genotypic data among cases and controls. According to the inclusion criteria, 17 articles [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28], were finally selected for further analysis (see Fig. 1, literature selections in each stage).…”

Glutathione transferases and neurodegenerative diseases

“…In fact, the onset of the disease was an average age of 68 years among patients carrying the GSTM1 gene, compared to the average age of 57 years among those with null genotype (Ahmadi et al, 1999;Perez-Pastene et al, 2007). Also with regard to AD, the null genotype is a risk factor (Piacentini et al, 2012a). The association between PD and pesticide exposure is enhanced in the presence of null GSTM1 gene .…”