GSTM1 null polymorphisms is associated with laryngeal cancer risk: a meta-analysis

Abstract

Many studies have examined the association between the GSTM1 (null or non-null genotype) polymorphism and laryngeal cancer risk in various populations, but their results have been inconsistent. To assess this relationship more precisely, a meta-analysis was performed. PubMed was searched for case-control studies published up to December 2013. Data were extracted and pooled odds ratios (OR) with 95 % confidence intervals (CI) were calculated. Ultimately, 23 studies, comprising 2,562 laryngeal cancer cases and 4,091 controls, were included. Overall, for null versus present, the pooled OR was 1.22 (95 % CI = 1.10-1.36), and the heterogeneity was found in all studies. In the stratified analysis by ethnicity, significant risks were found among Asians (OR = 1.71; 95 % CI = 1.34-2.19; P = 0.011 for heterogeneity) and in Caucasians (OR = 1.13, 95 % CI = 1.00-1.27; P = 0.036 for heterogeneity). In conclusion, this meta-analysis demonstrates that the GSTM1 null gene polymorphism is an increased risk of laryngeal cancer in Asians and Caucasians.

A genetic view of laryngeal cancer heterogeneity

“…GSTM1 null genotype appears to confer increased SCCHN and particularly laryngeal increased risk (OR D 1.22, 95% CI 1.1-1.36). 21,22 The variant Val allele of the CYP1A1 Ile462Val polymorphism is another consistent susceptibility maker for SCCHN, with a 35% increased risk in a meta-analysis of 12 studies. 22 Presenting fast metabolizing alleles for alcohol dehydrogenase (ADH), ADH1B and ALDH2 genes, resulted in increased acetyladehyde levels and associated with HNSCC significantly interacting with alcohol consumption.…”

“…21,22 The variant Val allele of the CYP1A1 Ile462Val polymorphism is another consistent susceptibility maker for SCCHN, with a 35% increased risk in a meta-analysis of 12 studies. 22 Presenting fast metabolizing alleles for alcohol dehydrogenase (ADH), ADH1B and ALDH2 genes, resulted in increased acetyladehyde levels and associated with HNSCC significantly interacting with alcohol consumption. 23 In a case-control study single nucleotide polymorphisms (SNPs) in nucleotide excision repair (NER) genes such as ERCC5, ERCC6 and RAD23B could modify laryngeal cancer risk.…”