Combined Cycle Power Plants (CCPPs) are imperative for power generation with the capability for deciphering power shortage during peak and off peak hours. To perk up the recital of the plant, foremost locations of exergy losses are to be identified and analyzed. In the present work, exergetic analysis of a CCPP is carried out using the computer programming tool Engineering Equation Solver (EES). The effects of overall pressure ratio and turbine inlet temperature on the exergy destruction in the CPR are investigated. The results obtained are compared with that of simple gas turbine cycle power plant. During real time operation of CCPP exergy destruction in different components is associated with change in overall pressure ratio and turbine inlet temperature (TIT). Out of the total exergy destruction in the cycle it is the combustion chamber (CC) which is responsible for the maximum exergy destruction. Nearly 60% of the total exergy is destroyed in CC. Results clearly show that with increase in complicacy of the power plant structure, irreversibility of the processes can be improved.