Gualou-Xiebai herb pair and its active ingredients act against atherosclerosis by suppressing VSMC-derived foam cell formation via regulating P2RY12-mediated lipophagy

Bao, Youli; Zhu, Li; Wang, Yuting; Liu, Jiahui; Liu, Zijian; Li, Zhenglong; Zhou, An; Wu, Hongfei

doi:10.1016/j.phymed.2024.155341

Phytomedicine

2024

DOI: 10.1016/j.phymed.2024.155341

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Gualou-Xiebai herb pair and its active ingredients act against atherosclerosis by suppressing VSMC-derived foam cell formation via regulating P2RY12-mediated lipophagy

Youli Bao,

Li Zhu,

Yuting Wang

et al.

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Cited by 2 publications

References 39 publications

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NCOA4 linked to endothelial cell ferritinophagy and ferroptosis:a key regulator aggravate aortic endothelial inflammation and atherosclerosis

Zhu,

Liu,

Liu

et al. 2025

Redox Biology

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NCOA4 linked to endothelial cell ferritinophagy and ferroptosis:a key regulator aggravate aortic endothelial inflammation and atherosclerosis

Zhu,

Liu,

Liu

et al. 2025

Redox Biology

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An update on ox-LDL-inducing vascular smooth muscle cell-derived foam cells in atherosclerosis

Guo,

2024

Front. Cell Dev. Biol.

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Excess cholesterol accumulation induces the accumulation of foam cells, eventually accelerating atherosclerosis progress. Historically, the mechanisms of macrophage-derived foam cells have attracted attention because of their central role in plaque development, which was challenged by lineage tracing in union with single-cell sequencing (sc-seq). Accumulated studies have uncovered how vascular smooth muscle cells (VSMCs) proliferate and migrate to the vascular intima and accumulate, then transform into foam cells induced by surplus lipids, finally accounting for 30% to 70% of the total foam cells within the plaque of both mice and humans. Therefore, the mechanisms of VSMC-derived foam cells have received increasing attention. The review intends to summarize the transformation mechanism of VSMCs into foam cells induced by oxidized low-density lipoproteins (ox-LDL) in atherosclerosis.

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Gualou-Xiebai herb pair and its active ingredients act against atherosclerosis by suppressing VSMC-derived foam cell formation via regulating P2RY12-mediated lipophagy

Cited by 2 publications

References 39 publications

NCOA4 linked to endothelial cell ferritinophagy and ferroptosis:a key regulator aggravate aortic endothelial inflammation and atherosclerosis

NCOA4 linked to endothelial cell ferritinophagy and ferroptosis:a key regulator aggravate aortic endothelial inflammation and atherosclerosis

An update on ox-LDL-inducing vascular smooth muscle cell-derived foam cells in atherosclerosis

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