Guanidinbernsteinsäure und Urämie

Dobbelstein, H; Grunst, J.; Schubert, G.; Edel, H. H.

doi:10.1007/bf01732918

Cited by 13 publications

(9 citation statements)

References 10 publications

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“…The 74 ± 7.5% we obtained is comparable with the 85% decrease re ported by Dobbelstein et al [26]. Kopple et al [23] ob tained a 39±21% decrease, Cohen [6] one o f approxi mately 42% and Perez et al [22] a 53 ±5% decrease for G S A .…”

Section: Discussionsupporting

confidence: 77%

“…The lower decreases for G S A , compared to ours, obtained by Kopple et al [23] and Perez et al [22], could be explained by differences in dialysis time and blood flow rate. Perez et al [22] reported a decrease in plasma G S A immediately after dialysis that was proportional to those o f urea and creatinine; we obtained, like Dobbelstein et al [26], a greater decrease for G S A than for C T N (56 ±9.2%) and urea (61 ±7.4%). Perez et al [24] reported unchanged G and M G levels after a single H D .…”

Section: Discussionsupporting

confidence: 60%

“…Previous reports evaluating the dialyzability o f G C s dealt only with a limited number of substances using different, less sensitive assay methods [6,[22][23][24][25][26]. Some of these studies considered rather small and heterogeneous groups o f patients and lacked sufficient documentation on the H D prescription.…”

Section: Introductionmentioning

confidence: 99%

“…Although controversial [8], guanidinosuccinic acid (G SA ) is believed to be related to the uremic bleeding diathesis [9. 10].…”

Section: Introductionmentioning

confidence: 99%

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Serum Guanidino Compound Levels and the Influence of a Single Hemodialysis in Uremic Patients Undergoing Maintenance Hemodialysis

Deyn

Marescau

Lornoy

et al. 1987

Nephron

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Guanidino compounds are increased in uremia and are highly suspected to be uremic toxins. The serum levels of 11 guanidino compounds and the influence of a single hemodialysis were evaluated in 30 steady-state uremic patients undergoing maintenance hemodialysis. Guanidino compound levels were detected using liquid cation exchange chromatography with a highly sensitive fluorescence detection method. Highly standardized dialysis procedures were performed. Before hemodialysis, high levels were found for guanidinosuccinic acid, N-α-acetylarginine, argininic acid, creatinine, γ-guanidinobutyric acid, guanidine and methylguanidine. Guanidinosuccinic acid reached levels associated with toxic effects in vitro. After hemodialysis, although lowered, guanidinosuccinic acid, creatinine, guanidine and methylguanidine were still markedly increased. No differences in the percent decrease, during a single hemodialysis, of the studied compounds were found using different membranes such as cellulose acetate, cuprophane and polyacrylonitrile membranes. Substantial differences, however, in the percent decrease of the different guanidino compounds were found, ranging from 25 ± 13% for arginine to 74 ± 7.5% for guanidinosuccinic acid. Data reported here show that guanidino compounds are raised in serum of uremic patients undergoing maintenance hemodialysis, before as well as after a single hemodialysis, while substantial differences in the percent decrease of the different guanidino compounds are found.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionsupporting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

“…Although controversial [8], guanidinosuccinic acid (G SA ) is believed to be related to the uremic bleeding diathesis [9. 10].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Serum Guanidino Compound Levels and the Influence of a Single Hemodialysis in Uremic Patients Undergoing Maintenance Hemodialysis

Deyn

Marescau

Lornoy

et al. 1987

Nephron

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“…The reduction of arginine turnover rate in the urea cycle may play an important role to decrease the MG production be cause the reduced urea production during periods II and III is considered to indicate a lowered turnover rate. The role of GSA as a uremic toxin has been estimated from clinical studies [51,52] and some toxic effects in vitro [16.27-31]. By these reports, GSA is likely to have a bio chemical basis for uremic signs.…”

Section: Discussionmentioning

confidence: 99%

Effect of Low Protein Diet and Surplus of Essential Amino Acids on the Serum Concentration and the Urinary Excretion of Methylguanidine and Guanidinosuccinic Acid in Chronic Renal Failure

Ando¹,

Orita²,

Nakata³

et al. 1979

Nephron

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20 patients with moderate renal failure (serum creatinine 4.5–12.0 mg/dl) and some uremic symptoms on a diet ad libitum were treated with a high caloric diet containing 0.5–0.7 g/kg/day protein, supplemented with eight essential amino acids and histidine in the form of solution and/or granules. During the treatment uremic symptoms subsided or diminished without the signs of malnutrition, SUN and the ratio SUN/S-creatinine fell and the nitrogen balance and the ratio N-balance/intake N improved. The serum concentration and the urinary excretion of MG and GSA of the 12 patients were determined by Stein’s method using the modified Sakaguchi reaction. In all patients, the serum, concentration and the urinary excretion of MG and GSA diminished remarkably during the treatment with a low protein diet alone and furthermore with a low protein diet and essential amino acid supply. We concluded that conservative treatment – low nitrogen diet supplemented with sufficient calories and essential amino acids – improved the nutritional state of uremic subjects, and decreased the metabolic production of MG and GSA. The results show that the supplementation of essential amino acids to uremic patients may be a useful treatment.

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Pathogenese und Klinik von Organstörungen bei Urämie: Encephalo- und Neuropathien

Dobbelstein

1974

Achtzigster Kongress

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Guanidinbernsteinsäure und Urämie

Cited by 13 publications

References 10 publications

Serum Guanidino Compound Levels and the Influence of a Single Hemodialysis in Uremic Patients Undergoing Maintenance Hemodialysis

Serum Guanidino Compound Levels and the Influence of a Single Hemodialysis in Uremic Patients Undergoing Maintenance Hemodialysis

Effect of Low Protein Diet and Surplus of Essential Amino Acids on the Serum Concentration and the Urinary Excretion of Methylguanidine and Guanidinosuccinic Acid in Chronic Renal Failure

Pathogenese und Klinik von Organstörungen bei Urämie: Encephalo- und Neuropathien

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