2014
DOI: 10.1016/j.jinorgbio.2013.12.007
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Guanidine platinum(II) complexes: synthesis, in vitro antitumor activity, and DNA interactions

Abstract: The novel guanidine compounds trans-[Pt(NH2Me)2{NH=C(NHMe)NR}2](Cl)2 (R = NEt2 [7], NC5H10 [8]) (trans-7,8) were synthesized by the nucleophilic addition of methylamine to dialkylcyanamide ligands of the push–pull nitrile complexes trans-[PtCl2(RCN)2] (R = NEt2, NC5H10). In vitro cytotoxicity tests conducted for the entire series of the guanidine complexes, i.e. trans-7,8, the neutral cis- or trans-[PtCl2{NH=C(NH2)R}2] (cis-1–3 and trans-1–3) and the cationic cis- or trans-[Pt(NH3)2{NH=C(NH2)R}2](Cl)2 (cis-4–6… Show more

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Cited by 31 publications
(16 citation statements)
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“…IC 50 was the concentration [µM/L] of a tested compound required to achieve half maximal inhibition of cells proliferation 23. The normal modes description was made by visual inspection of the individual modes using the GaussView program.…”
mentioning
confidence: 99%
“…IC 50 was the concentration [µM/L] of a tested compound required to achieve half maximal inhibition of cells proliferation 23. The normal modes description was made by visual inspection of the individual modes using the GaussView program.…”
mentioning
confidence: 99%
“…Therefore, FGFR3 expression may lead to the activation of the MAPK pathway. Furthermore, numerous studies have provided evidence to suggest that the NME2 gene may be associated with cancer (42,43).…”
Section: Discussionmentioning
confidence: 99%
“…Instead of a bi-dentate aromatic ligand, the platinum (II) center is coordinated with two mono-dentate, cyanamide groups, with a positive charge on the nitrogen atom of the trimethylamine substituent. This cyanamide-containing complex has been employed to evaluate on its anti-tumor activity and DNA interaction [35]. Similar structures have been found as precursors for different metal complexes (Pt, Zn, Ni, Pd, Co).…”
Section: Design Of Platinum Complexes and Evaluation Of Their Cytotoxmentioning
confidence: 92%