Guanxin V alleviates ventricular remodeling after acute myocardial infarction with circadian disruption by regulating mitochondrial dynamics

Cheng, Songyi; Wu, Jing; Pei, Yinghao; Tong, Huaqin; Fan, Manlu; Xiang, Qian; Ding, Yuhan; Xie, Liang; Zhang, Haowen; Sun, Weixin; Zhang, Xiaoxiao; Zhu, Yongchun; Gu, Ning

doi:10.1007/s11325-023-02974-2

Sleep Breath

2023

DOI: 10.1007/s11325-023-02974-2

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Guanxin V alleviates ventricular remodeling after acute myocardial infarction with circadian disruption by regulating mitochondrial dynamics

Songyi Cheng,

Jing Wu,

Yinghao Pei

et al.

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2024

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Cited by 2 publications

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Effect of traditional Chinese medicine on metabolism disturbance in ischemic heart diseases

Wang,

Song,

et al. 2024

Journal of Ethnopharmacology

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Effect of traditional Chinese medicine on metabolism disturbance in ischemic heart diseases

Wang,

Song,

et al. 2024

Journal of Ethnopharmacology

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Research progress on the natural products in the intervention of myocardial infarction

Guo,

Wang,

et al. 2024

Front. Pharmacol.

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Coronary heart disease is a prevalent cardiovascular ailment globally, with myocardial infarction (MI) being one of its most severe manifestations. The morbidity and mortality of MI are escalating, showing an increasing trend among younger, highly educated individuals, thereby posing a serious threat to public health. Currently, thrombolysis, percutaneous coronary intervention, and coronary artery bypass grafting are the primary clinical treatments for MI. Although these methods significantly reduce patient mortality, complications often result in poor prognoses. Due to limitations in chemical synthetic drug research, the focus has shifted towards developing herbs based on natural substances. Natural medicines represent a novel approach for safer and more effective MI management and treatment. They can control multiple pathogenic variables by targeting various pathways and systems. This paper investigates the molecular mechanisms of MI and evaluates the application of natural products and medicinal plants in MI treatment over the past 5 years, demonstrating their specific good therapeutic potential and superior tolerance. These natural therapies have been shown to mitigate myocardial cell damage caused by MI through mechanisms such as oxidative stress, inflammation, apoptosis, angiogenesis, myocardial fibrosis, autophagy, endoplasmic reticulum stress, mitophagy, and pyroptosis. This review offers the latest insights into the application of natural products and medicinal plants in MI treatment, elucidating their mechanisms of action and serving as an important reference for MI prevention.

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Guanxin V alleviates ventricular remodeling after acute myocardial infarction with circadian disruption by regulating mitochondrial dynamics

Cited by 2 publications

References 36 publications

Effect of traditional Chinese medicine on metabolism disturbance in ischemic heart diseases

Effect of traditional Chinese medicine on metabolism disturbance in ischemic heart diseases

Research progress on the natural products in the intervention of myocardial infarction

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