Guanylyl cyclase mediates ANP-induced vasoconstriction of  murine splenic vessels

Andrew, Peter; Kaufman, Susan

doi:10.1152/ajpregu.00417.2002

Cited by 16 publications

(9 citation statements)

References 30 publications

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“…In addition, a vasoconstrictory effect of NO has been shown in the dogfish shark Squalus acanthias (Evans and Gunderson, 1998;Evans, 2000). Interestingly, a vasoconstriction mediated by cGMP signalling has recently been demonstrated in murine splenic vessels (Andrews and Kaufman, 2003).…”

Section: Discussionmentioning

confidence: 98%

Nitric oxide control of the dorsal aorta and the intestinal vein of the Australian short-finned eel Anguilla australis

Jennings

Broughton

Donald

2004

Journal of Experimental Biology

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of the endothelium. The nicotine-mediated dilation was blocked by the NOS inhibitor, N ω -nitro-L-arginine (L-NNA; 10 -4 ·mol·l -1 ), and ODQ (10 -5 ·mol·l -1 ). More specifically, the neural NOS inhibitor, N ω -propyl-Larginine (10 -5 ·mol·l -1 ), significantly decreased the dilation induced by nicotine (3×10 -4 ·mol·l -1 ). Furthermore, indomethacin (10 -5 ·mol·l -1 ) did not affect the nicotinemediated dilation, suggesting that prostaglandins are not involved in the response. Finally, the calcium ionophore A23187 (3×10 -6 ·mol·l -1 ) caused an endothelium-dependent dilation that was abolished in the presence of indomethacin. We propose the absence of an endothelial NO system in eel vasculature and suggest that neurally derived NO contributes to the maintenance of vascular tone in this species. In addition, we suggest that prostaglandins may act as endothelially derived relaxing factors in A. australis.

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Section: Discussionmentioning

confidence: 98%

Nitric oxide control of the dorsal aorta and the intestinal vein of the Australian short-finned eel Anguilla australis

Jennings

Broughton

Donald

2004

Journal of Experimental Biology

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“…Moreover, the splenic activity of ANP appeared to be specifically mediated by the natriuretic peptide receptor A (NPR-A) because local infusion of an NPR-Cspecific agonist did not change splenic hemodynamics or intravascular pressure . Furthermore, we demonstrated that in contrast to ANP's accepted role as a vasodilator, this hormone in fact caused endotheliumindependent vasoconstriction of isolated murine splenic blood vessels, which was mediated via guanylyl cyclase A (GC-A) (Andrew and Kaufman 2003;Ehmke 2003). ANPinduced vasoconstriction is not peculiar to the spleen.…”

Section: Mechanisms Underlying Splenic Fluid Extravasationmentioning

confidence: 90%

Role of spleen in integrated control of splanchnic vascular tone: physiology and pathophysiologyThis article is part of a Special Issue on Information Transfer in the Microcirculation.

Hamza

Kaufman

2009

Can. J. Physiol. Pharmacol.

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Aside from its established immunologic and hematologic functions, the spleen also plays an important role in cardiovascular regulation. This occurs through changes in intrasplenic microvascular tone, as well as through splenic neurohormonal modulation of the renal and mesenteric vascular beds. Splenic regulation of blood volume occurs predominantly through fluid extravasation from the splenic circulation into lymphatic reservoirs; this is controlled by direct modulation of splenic pre- and postcapillary resistance by established physiologic agents such as atrial natriuretic peptide (ANP), nitric oxide (NO), and adrenomedullin (ADM). In addition to physiologic fluid regulation, splenic extravasation is a key factor in the inability to maintain adequate intravascular volume in septic shock. The spleen also controls renal microvascular tone through reflex activation of the splenic afferent and renal sympathetic nerves. This splenorenal reflex not only contributes to the physiologic regulation of blood pressure, but also contributes to the cardiovascular dysregulation associated with both septic shock and portal hypertension. In septic shock, the splenorenal reflex protectively limits splenic extravasation and potentially promotes renal sodium and water reabsorption and release of the vasoconstrictor angiotensin II; this function is eventually overwhelmed as shock progresses. In portal hypertension, on the other hand, the splenorenal reflex-mediated reduction in renal vascular conductance exacerbates sodium and water retention in the kidneys and may eventually contribute to renal dysfunction. Preliminary evidence suggests that the spleen also may play a role in the hemodynamic complications of portal hypertension via neurohormonal modulation of the mesenteric vascular bed. Lastly, the spleen itself may be a source of a vasoactive factor.

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“…A pressure myograph system (Living Systems Instrumentation, USA) was used to determine arteriolar myogenic reactivity and responsiveness to nitric oxide, as previously described [19], [20].…”

Section: Methodsmentioning

confidence: 99%

Interleukin-1 Regulates Multiple Atherogenic Mechanisms in Response to Fat Feeding

et al. 2009

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BackgroundAtherosclerosis is an inflammatory process that develops in individuals with known risk factors that include hypertension and hyperlipidaemia, influenced by diet. However, the interplay between diet, inflammatory mechanisms and vascular risk factors requires further research. We hypothesised that interleukin-1 (IL-1) signaling in the vessel wall would raise arterial blood pressure and promote atheroma.Methodology/Principal Findings Apoe−/− and Apoe−/−/IL-1R1−/− mice were fed high fat diets for 8 weeks, and their blood pressure and atherosclerosis development measured. Apoe−/−/IL-R1−/− mice had a reduced blood pressure and significantly less atheroma than Apoe−/− mice. Selective loss of IL-1 signaling in the vessel wall by bone marrow transplantation also reduced plaque burden (p<0.05). This was associated with an IL-1 mediated loss of endothelium-dependent relaxation and an increase in vessel wall Nox 4. Inhibition of IL-1 restored endothelium-dependent vasodilatation and reduced levels of arterial oxidative stress.Conclusions/SignificanceThe IL-1 cytokine system links atherogenic environmental stimuli with arterial inflammation, oxidative stress, increased blood pressure and atherosclerosis. This is the first demonstration that inhibition of a single cytokine can block the rise in blood pressure in response to an environmental stimulus. IL-1 inhibition may have profound beneficial effects on atherogenesis in man.

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Guanylyl cyclase mediates ANP-induced vasoconstriction of murine splenic vessels

Cited by 16 publications

References 30 publications

Nitric oxide control of the dorsal aorta and the intestinal vein of the Australian short-finned eel Anguilla australis

Nitric oxide control of the dorsal aorta and the intestinal vein of the Australian short-finned eel Anguilla australis

Role of spleen in integrated control of splanchnic vascular tone: physiology and pathophysiologyThis article is part of a Special Issue on Information Transfer in the Microcirculation.

Interleukin-1 Regulates Multiple Atherogenic Mechanisms in Response to Fat Feeding

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