Gubernacular development in Müllerian inhibiting substance receptor-deficient mice

Bartlett, J.E.; Lee, S.M.Y.; Mishina, Yuji; Behringer, Richard R.; Yang, Na; Wolf, J.; Temelcos, Catherine; Hutson, John M.

doi:10.1046/j.1464-4096.2001.00783.x

Cited by 33 publications

(14 citation statements)

References 20 publications

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“…To directly test a role for this receptor in the developing retina, we specifically disrupted Bmpr1a gene function using the Six3Cre transgene, which drives Cre recombinase expression in the retina and ventral forebrain (Furuta et al, 2000). The conditional Bmpr1a allele results in a null allele upon Cre mediated recombination (Bartlett et al, 2002). In our mating scheme, we employ a combination of the null allele (Mishina et al, 1995) and conditional allele; mice transheterozygotes for these alleles (referred to as Bmpr1a -/fx below) are thus hemizygous for the Bmpr1a locus prior to Cre-mediated recombination.…”

Section: Bmpr1a Function Is Not Essential For Retinal Developmentmentioning

confidence: 99%

Distinct developmental programs require different levels of Bmp signaling during mouse retinal development

et al. 2005

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The Bmp family of secreted signaling molecules is implicated in multiple aspects of embryonic development. However, the cell-type-specific requirements for this signaling pathway are often obscure in the context of complex embryonic tissue interactions. To define the cell-autonomous requirements for Bmp signaling, we have used a Cre-loxP strategy to delete Bmp receptor function specifically within the developing mouse retina. Disruption of a Bmp type I receptor gene, Bmpr1a, leads to no detectable eye abnormality. Further reduction of Bmp receptor activity by removing one functional copy of another Bmp type I receptor gene, Bmpr1b, in the retina-specific Bmpr1a mutant background, results in abnormal retinal dorsoventral patterning. Double mutants completely lacking both of these genes exhibit severe eye defects characterized by reduced growth of embryonic retina and failure of retinal neurogenesis. These studies provide direct genetic evidence that Bmpr1a and Bmpr1b play redundant roles during retinal development, and that different threshold levels of Bmp signaling regulate distinct developmental programs such as patterning, growth and differentiation of the retina.

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Section: Bmpr1a Function Is Not Essential For Retinal Developmentmentioning

confidence: 99%

Distinct developmental programs require different levels of Bmp signaling during mouse retinal development

et al. 2005

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“…lar descent have been thought to be controlled by Mülle-rian inhibitory substance [Fentener van Vlissingen et al, 1988; but for contrary evidence, see Bartlett et al, 2002] by insulin-like 3 peptide [Nef and Parada, 1999;Tomiyama et al, 2003; but for contrary evidence, see Yuan et al, 2006] and by androgens. Much of the evidence for androgen involvement has derived from the blockade of androgen receptors during development by antiandrogens or from mutations of the androgen receptor, both of which can inhibit testicular descent [Hutson and Donahoe, 1986;Husmann and McPhaul, 1991b;Husmann et al, 1994;Spencer et al, 1991Spencer et al, , 1993Van der Schoot, 1992b].…”

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confidence: 99%

Does the Cranial Suspensory Ligament Have a Role in Cryptorchidism?

Kassim

Russell

Payne

2009

Cells Tissues Organs

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The cranial suspensory ligament (CSL) is a fibromuscular structure anchoring the embryonic gonad to the posterior abdominal wall in male and female mammals. Its persistence in females is believed to be responsible for retaining the ovaries within the abdomen, while its regression in males permits testis descent. Embryonic loss of the CSL in males is believed to be an androgen-dependent event, and failure of this process has been proposed as a cause of cryptorchidism. The present study demonstrates that the nuclei of mesenchymal cells in the caudal part of the CSL are immunoreactively positive for androgen receptor. We examined the effects of exposure of the non-steroidal antiandrogen flutamide during the period from gestational day 10 to birth on the development of the CSL and on testis descent. Exposure of male Albino Swiss rats to the antiandrogen flutamide during this period resulted in feminization of the external genitalia and the suppression of growth of the testes and male reproductive tracts. In adulthood, testes were found to be located in diverse positions including normal scrotal (50%), intra-abdominal (10%) and ectopic suprainguinal (40%). The CSL of the testis persisted into adulthood in all flutamide-treated males, regardless of testis location. In all cases, the ligament consisted of bundles of smooth muscle fibres in the retroperitoneal fat of the posterior abdominal wall. These findings suggest that androgen blockade during embryonic development interferes with testicular descent, but that maldescent cannot be correlated with either the persistence of the CSL of the testis or its structure.

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“…Particularly, first degree relatives of PMDS patients should undergo screening particularly if they suffer from undescended testis. Mutations involving chromosome 19 (receptor type 1) and chromosome 12 (receptor type 2) have been reported (3,6). Undescended testis accompanies PMDS because Müllerian structures block the descent of the testis.…”

Section: Discussionmentioning

confidence: 99%

A Rare Presentation of Germ Cell Neoplasia: Persistant Müllerian Duct Syndrome

Beksaç¹,

Dönmez²,

Aydın³

et al. 2017

uob

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Gubernacular development in Müllerian inhibiting substance receptor-deficient mice

Abstract: Although there was an observable effect on cremaster muscle development in these mutant mice, gubernacular development and testicular descent were otherwise normal, and thus there must be other reasons for the observed differences in humans with persistent Müllerian duct syndrome.

Cited by 33 publications

References 20 publications

Distinct developmental programs require different levels of Bmp signaling during mouse retinal development

Distinct developmental programs require different levels of Bmp signaling during mouse retinal development

Does the Cranial Suspensory Ligament Have a Role in Cryptorchidism?

A Rare Presentation of Germ Cell Neoplasia: Persistant Müllerian Duct Syndrome

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