Guggulsterone, an anti-inflammatory phytosterol, inhibits tissue factor and arterial thrombosis

Chemical composition and anti-arthritic activity of Anacyclus valentinus extract on adjuvant-induced arthritis in rats

“…On the one hand, the increase in the weight of the spleen occurs following the release of the cytokines causing a perturbation of the histology of this organ. On the other hand, the variation in thymus weight is due to the suppression or imbalance of the immune system [28]. In the present study, it was found that MEAV significantly decreased the spleen index and thymus index induced by FCA compared with FCA group.…”

Evaluation of anti-inflammatory potential of ayurvedic formulation Rheumacure in animal model of rheumatoid arthritis

“…Whereas, the decrease in thymus weight is due to a suppression of immune system. 17,18 Treatment produced decrease in index of spleen of the arthritic rats, whereas no significant impact on the index of thymus was observed. The decrease in thymus weights in the dexamethasone treated rats was higher as compared to RC treated group indicates that RC played an important role in the immune system mainly by inhibiting the enlargement of the spleen and the expansion of immune cells of thymus, which may be due to presence of suvarna makshik bhasma and shankh bhasma, a mineral which has been reported to have immunoprotective effects.…”

“…The effect may be due to suppression of inflammation and inhibition of synthesis of chemical mediators because RC contains Mahayogaraj Guggulu, Trayodashang Guggulu which have been proved to be anti-inflammatory by the mechanisms may be associated with the inhibition of inflammatory mediator overproduction. 17 The RC also contains Maharasnadi Kwath, Suvarna Makshik Bhasma and Shankh Bhasma which is a very famous Ayurvedic medicine used in Vata disorders like Kampavata, hemiplegia, paraplegia, Neck pain, low back pain, rheumatoid arthritis, osteoarthritis, knee pain and hip pain.…”

Laminin receptor activation inhibits endothelial tissue factor expression

“…Human aortic endothelial cells (HAEC; Clonetics, Allschwil, Switzerland), human umbilical venous endothelial cells (HUVEC; Clonetics) and human aortic vascular smooth muscle cells (HASMC, Clonetics) were cultured on fibronectin as described [20]. Cells were rendered quiescent in medium supplemented with 0.5% fetal bovine serum for 24 hours before stimulation with 5 ng/mL TNF-α (R&D Systems, Minneapolis, MN) or 10 μM histamine (Sigma, St. Louis, MO).…”

“…RNA was extracted from HAEC using TRIzol Reagent (Invitrogen, Carlsbad, CA) and real-time PCR performed as described [20]. …”