Guías de práctica clínica de la Sociedad Española de Cardiología en hipertensión arterial

Romero, F. Lombera; Alonso, Vivencio Barrios; Arcos, Federico Soria; Peralta, Luis Placer; Fernández, José Marı́a; Abadal, Luis Tomás; Padial, Luis Rodrı́guez; Juanatey, José Ramón González

doi:10.1016/s0300-8932(00)75065-2

Cited by 41 publications

(2 citation statements)

References 115 publications

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“…In accordance with the Spanish Society of Cardiology’s Guidelines on Arterial Hypertension criteria [20], hypertensive individuals were defined as those whose systolic arterial pressure was ≥140 mmHg and/or whose diastolic arterial pressure was ≥90 mmHg, measured on two separate occasions separated by at least two weeks. NCEP-ATPIII 2001 [21] criteria were used in determining hypercholesterolemia.…”

Section: Methodsmentioning

confidence: 99%

CD36 overexpression: a possible etiopathogenic mechanism of atherosclerosis in patients with prediabetes and diabetes

López-Carmona

Plaza-Serón

Vargas-Candela

et al. 2017

Diabetol Metab Syndr

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RationaleCD36 is a scavenger receptor located on monocytes which is involved in foam cell transformation.AimTo evaluate CD36 expression under different glycemic states in both healthy subjects and in atherosclerotic patients.Subjects and methodsIn order to evaluate the possible effects of hyperglycemia on CD36 expression in healthy subjects, an in vitro experiment was carried out using monocyte in three different conditions: extreme hyperglycemia (HG), euglycemia (EG) and in the absence of glucose. On the other hand, three groups of atherosclerotic patients were evaluated according to their glycemic conditions: normoglycemic (NG), prediabetic (preDM) and diabetic (DM) patients. CD36 expression (mRNA, non-glycated and glycated protein) was analyzed in monocytes.ResultsCD36 mRNA expression in the in vitro experiment peaked at 4 and 24 h under HG conditions. No differences in mRNA levels were found in the EG and control group. The level of non-glycated proteins was higher in HG and EG conditions compared with control group. Glycated protein expression was inhibited by glucose in a sustained manner. In atherosclerotic patients, a significant association was observed when comparing glycated CD36 protein expression in DM with NG patients (p = 0.03). No significant differences were found in mRNA and non-glycated CD36 expression in these patients. Moreover, BMI, insulin, weight and treatment were shown to be related to CD36 expression (mRNA, non-glycated and glycated protein levels, depending of the case) in atherosclerotic patients.ConclusionsHyperglycemia is an important modulator of CD36 mRNA and non-glycated protein expression in vitro, increasing de novo synthesis in healthy subjects. In atherosclerotic patients, there are progressive increases in CD36 receptors, which may be due to a post-translational stimulus.

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Section: Methodsmentioning

confidence: 99%

CD36 overexpression: a possible etiopathogenic mechanism of atherosclerosis in patients with prediabetes and diabetes

López-Carmona

Plaza-Serón

Vargas-Candela

et al. 2017

Diabetol Metab Syndr

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“…Almost half of hypertensive patients are not on treatments, and a higher proportion of patients with hypertension, diabetes, and kidney disease are not on treatment. Therefore, a simple treatment is recommended to improve compliance [10] and early initiation of medication for higher risk patients [11]. …”

Section: Introductionmentioning

confidence: 99%

Characteristics and Factors Associated With Antihypertensive Medication Use in Patients Attending Peruvian Health Facilities

Mejía

Failoc‐Rojas

et al. 2017

Cureus

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Introduction Hypertension is a very common disease worldwide, and medication is needed to prevent its short-term and long-term complications. Our objective was to determine the characteristics and factors associated with antihypertensive medication use in patients attending Peruvian health facilities.Materials & MethodsWe performed a multicenter, cross-sectional study with secondary data. We obtained self-reported antihypertensive medication from patients attending health facilities in 10 departments of Peru. We looked for associations of the antihypertensive treatment according to sociopathological factors and obtained p values using generalized linear models.ResultsOf the 894 patients with hypertension, 61% (547) were women and 60% (503) were on antihypertensive treatment, of which 82% (389) had monotherapy and 52% (258) had recently taken their medication. Antihypertensive treatment was positively correlated with the patient's age (adjusted prevalence ratio [aPR]: 1.01; 95% confidence interval [CI]: 1.007 to 1.017; p value < 0.001), diabetes (aPR: 1.31; 95% CI: 1.11 to 1.55; p value = 0.001) and cardiovascular disease (aPR: 1.38; 95% CI: 1.26 to 1.51; p value < 0.001). Conversely, the frequency of antihypertensive treatment decreases with physical activity (aPR: 0.80; 95% CI: 0.70 to 0.92; p value = 0.001).ConclusionPatients who have comorbidities and advanced age are more likely to be on antihypertensive treatment. In contrast, patients with increased physical activity have a lower frequency of antihypertensive treatment. It is important to consider these factors for future preventive programs and to improve therapeutic compliance.

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Adecuación y rendimiento del ecocardiograma en atención primaria

Figuera

Fernández

et al. 2012

Atención Primaria

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Guías de práctica clínica de la Sociedad Española de Cardiología en hipertensión arterial

Cited by 41 publications

References 115 publications

CD36 overexpression: a possible etiopathogenic mechanism of atherosclerosis in patients with prediabetes and diabetes

CD36 overexpression: a possible etiopathogenic mechanism of atherosclerosis in patients with prediabetes and diabetes

Characteristics and Factors Associated With Antihypertensive Medication Use in Patients Attending Peruvian Health Facilities

Adecuación y rendimiento del ecocardiograma en atención primaria

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