Background: Radicular cyst enucleation and reconstruction with bone graft is a surgical procedure used to remove a cyst that has formed around a tooth root. The procedure involves making an incision in the gum tissue to expose the cyst, removing the cyst and any affected bone, and then filling the resulting defect with a bone graft. The bone graft is typically taken from the patient's own body, such as from the chin or the iliac crest, and is used to promote new bone growth and help stabilize the surrounding teeth. After the procedure, the gum tissue is sutured back into place, and the patient may be prescribed pain medication and antibiotics to help manage any discomfort or infection. The success of the procedure depends on the size and location of the cyst, as well as the patient's overall oral health. Purpose: To aim management of cyst enucleation and reconstruction bone defect with bovine bone graft and protein rich plasma (PRP). Case(s): A female 19 years old with the chief complaint of the patient have caries io the lower left jaw tooth. The patient complains of frequent oedemmon left cheek site. On panoramic radiologic examination, a radiolucent lesion with a radiopaque border was found in the apical region of tooth 36. Case Management: The patient underwent enucleation of cyst and bone defect reconstruction with general anaesthesia. After 14 days, the sutures were removed and the wound were healed. Conclusion: This case of radicular cyst can be used for guideline with enucleation of radicular cyst and bone defect reconstrtion