2024
DOI: 10.1101/2024.05.03.592285
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GUIDE deconstructs genetic architectures using association studies

Daniel Lazarev,
Grant Chau,
Alex Bloemendal
et al.

Abstract: Genome-wide association studies have revealed that the genetic architecture of most complex traits is characterized by a large number of distinct effects scattered across the genome. Functional enrichment analyses of these results suggest that the associations for any given complex trait are not purely random. Thus, we set out to leverage the genetic association results from many traits with a view to identifying the set of modules, or latent factors, that mediate these associations. The identification of such… Show more

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