Guide lines for management of adult histiocytic disease

Salama, Hind; Alhejazi, Ayman; Absi, Ahmed; Alshieban, Saeed; Alzahrani, Mohsen; Alaskar, Ahmed; Gmati, Giamal; Damlaj, Moussab; Abuelgasim, Khadega A.; Ali, Osama; Alghamdi, Abdulrahman; Alahmari, Bader; Almugairi, Areej; Al-Zahrani, Hazza; ALhashmi, Hanni; Jazieh, Abdul Rahman

doi:10.4103/joah.joah_48_18

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“…Recommendations for the management of adult histiocytic disease are sparse. In 2018, our first set of local guidelines were published 1 ; however, owing to the discovery of new molecular data and incorporation of targeted therapies, these guidelines need refinement and updating for the different categories of histiocytic diseases. This document will provide highlights for management of the most commonly encountered histiocytic diseases (Langerhans cell histiocytosis, Erdheim-Chester disease, Rosai-Dorfman disease, and hemophagocytic lymphohistiocytosis).…”

Section: Introductionmentioning

confidence: 99%

Highlights of the Management of Adult Histiocytic Disorders: Langerhans Cell Histiocytosis, Erdheim-Chester Disease, Rosai-Dorfman Disease, and Hemophagocytic Lymphohistiocytosis

Salama

Jazieh

Alhejazi

et al. 2021

Clinical Lymphoma Myeloma and Leukemia

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Histiocytic disorders are an exceptionally rare group of diseases with diverse manifestations and a paucity of approved treatments, thereby leading to various challenges in their diagnosis and management. With the discovery of novel molecular targets and the incorporation of targeted agents in the management of various adult histiocytic disorders, their management has become increasingly complex. In an attempt to improve the understanding of the clinical features and management of common adult histiocytic disorders (Langerhans cell histiocytosis, Erdheim-Chester disease, Rosai-Dorfman disease, and hemophagocytic lymphohistiocytosis), we created this document based on existing literature and expert opinion.

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Section: Introductionmentioning

confidence: 99%