Background: Hypotension, or low arterial blood pressure (ABP), is a common complication during general anaesthesia, even in otherwise healthy animals. Recognition of the problem and an understanding of why it is occurring is necessary so that appropriate treatment can be implemented. Persistent hypotension may lead to organ injury if left untreated and can contribute to poor patient outcomes.Aim of the article: This article discusses the pathophysiology of hypotension during general anaesthesia and the treatment options available. Part one of this two‐part series, published in last month's In Practice, reviewed the physiology and measurement of ABP.