Guided bone regeneration (GBR) using membranes and calcium sulphate after apicectomy: a comparative histomorphometrical study

Yoshikawa, G.; Murashima, Yoshio; Wadachi, Reiko; Sawada, Naomasa; Suda, Hiroshi

doi:10.1046/j.1365-2591.2002.00473.x

Cited by 54 publications

(56 citation statements)

References 26 publications

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“…Yoshikawa et al, 4 in an experimental study in dogs with the use of e-PTFE membranes and CaS after apicectomy, found that bone regeneration with the use of CaS was similar to that obtained using e-PTFE and superior to controls. Pecora et al, 3 in a study using CaS in the surgical treatment of a through and through periradicular lesion, found that the addition of calcium sulfate to conventional surgical treatment of this type of endodontic lesions may contribute to an improvement of the clinical outcome.…”

Section: Discussionmentioning

confidence: 91%

“…[5][6][7][8][9][10][11][12] Calcium sulfate has been successfully used to treat periodontal disease, endodontic lesions, alveolar bone loss, and maxillary sinus augmentation. 3,4,[13][14][15][16][17] Calcium sulfate may act as a binder, facilitating healing and preventing loss of the grafting material; moreover, it is tissue compatible, and does not interfere with the healing process. 18 Calcium sulfate has also been used with other materials, such as autogenous bone, 2 DFDBA, 18 polymers, or HA; 19 in these cases there was a favorable effect on the potential for osteogenesis.…”

Section: Introductionmentioning

confidence: 99%

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Bone‐defect healing with calcium‐sulfate particles and cement: An experimental study in rabbit

et al. 2003

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Calcium sulfate (CaS) has been shown to be a reasonable alternative to autogenous bone graft for treating bone lesions in dentistry. The aim of this work was an histological study of the bone healing of defects treated with calcium sulfate in the form of cement or beads, in animal. Eight New Zealand rabbits, weighing about 2.5 Kg were used in this study. In each rabbit, four 6 mm bone defects were created in the tibial metaphysis. The 2 defects in the right tibia were filled with calcium sulfate as cement, while the 2 defects in the left one were filled with calcium sulfate as beads. Four rabbits were killed after respectively 2 and 4 weeks, with an intravenous injection of Tanax, and the block sections, containing the bone defects, were retrieved. A total of 16 defects filled by cement and a total of 16 defects filled by beads were retrieved. The specimens were processed to obtain thin ground sections with the Precise 1 Automated System. In the first phases of healing it was possible to observe an intense osteoblastic activity, and in some areas osteoid matrix was present. After two weeks the calcium sulfate (both cement and beads) was still present, and biological fluids and cells were present inside the material. Newly formed bone surrounded the calcium sulfate and filled about 10% of the defect. After four weeks the calcium sulfate was almost completely resorbed and substituted by new bone. Approximately 34% of the defects were filled by newly formed bone. BEI and XRM evaluations showed the structural components of the filled defects. In none of the specimens were inflammatory cells present. No significant differences were found using both calcium sulfate as cement and beads, and they both have shown a high biocompatibility, appearing to promote newly bone formation in the rabbit model, and they did not induce any untoward effect on the bone regeneration processes.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Bone‐defect healing with calcium‐sulfate particles and cement: An experimental study in rabbit

et al. 2003

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“…In such cases, the defect area must first be reconstructed before artificial tooth root implantation. To this end, guided bone regeneration (GBR) procedures have been noted as a reliable periodontal regeneration and alveolar augmentation therapy, and have registered high success rates in recent years [4]. Currently, there are two material systems for GBR procedures, namely degradable and non-degradable membrane materials [5].…”

Section: Introductionmentioning

confidence: 99%

Development of a Novel Degradation-Controlled Magnesium-Based Regeneration Membrane for Future Guided Bone Regeneration (GBR) Therapy

Lin

Hung

Lee

et al. 2017

Metals

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Abstract:This study aimed to develop and evaluate the ECO-friendly Mg-5Zn-0.5Zr (ECO505) alloy for application in dental-guided bone regeneration (GBR). The microstructure and surface properties of biomedical Mg materials greatly influence anti-corrosion performance and biocompatibility. Accordingly, for the purpose of microstructure and surface modification, heat treatments and surface coatings were chosen to provide varied functional characteristics. We developed and integrated both an optimized solution heat-treatment condition and surface fluoride coating technique to fabricate a Mg-based regeneration membrane. The heat-treated Mg regeneration membrane (ARRm-H380) and duplex-treated regeneration membrane group (ARRm-H380-F24 h) were thoroughly investigated to characterize the mechanical properties, as well as the in vitro corrosion and in vivo degradation behaviors. Significant enhancement in ductility and corrosion resistance for the ARRm-H380 was obtained through the optimized solid-solution heat treatment; meanwhile, the corrosion resistance of ARRm-H380-F24 h showed further improvement, resulting in superior substrate integrity. In addition, the ARRm-H380 provided the proper amount of Mg-ion concentration to accelerate bone growth in the early stage (more than 80% new bone formation). From a specific biomedical application point of view, these research results point out a successful manufacturing route and suggest that the heat treatment and duplex treatment could be employed to offer custom functional regeneration membranes for different clinical patients.

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“…1,2 In some cases, such as through-and-through osseous defects and in combined endodontic-periodontal lesions, there is large bone destruction which hinders apical healing by periodontal tissue regeneration. 3 Osseous defects may be repaired in two ways: healing by periodontal tissue regeneration or by fibrous scar tissue. Natural regeneration of large bone defects is usually incomplete and occurs by fibrous tissue.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, if a non-resorbable membrane is used, a second surgery is required to remove the membrane. 3 Lyophilized anorganic bovine bone is among the different types of material used for grafting. It is a xenograft obtained through deproteinization at high temperatures.…”

Section: Introductionmentioning

confidence: 99%

Alveolar bone regeneration in rats after grafting of anorganic bovine bone and thick synthetic bioceramic

Garcia¹,

Garcia²,

Tartari³

et al. 2014

Dental Press Endod

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Guided bone regeneration (GBR) using membranes and calcium sulphate after apicectomy: a comparative histomorphometrical study

Abstract: The data suggests that e-PTFE membrane is more effective compared to resorbable membranes and controls for bone regeneration after apicectomy, and that calcium sulphate could be substituted for e-PTFE membrane.

Cited by 54 publications

References 26 publications

Bone‐defect healing with calcium‐sulfate particles and cement: An experimental study in rabbit

Bone‐defect healing with calcium‐sulfate particles and cement: An experimental study in rabbit

Development of a Novel Degradation-Controlled Magnesium-Based Regeneration Membrane for Future Guided Bone Regeneration (GBR) Therapy

Alveolar bone regeneration in rats after grafting of anorganic bovine bone and thick synthetic bioceramic

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