Guided bone regeneration in pig calvarial bone defects using autologous mesenchymal stem/progenitor cells – A comparison of different tissue sources

Stockmann, Philipp; Park, Jung; Wilmowsky, Cornelius von; Nkenke, Emeka; Felszeghy, Endre; Dehner, Jan Friedrich; Schmitt, Christian; Tudor, Christian; Schlegel, Karl Andreas

doi:10.1016/j.jcms.2011.05.004

Cited by 118 publications

(98 citation statements)

References 38 publications

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“…Furthermore, a few in vivo studies have indicated that ADSCs secrete large amounts of bone morphogenetic proteins (BMPs), which accelerate osteogenesis [21]. However, a study by Stockmann et al [22] failed to reveal no statistical difference in bone reconstruction with SCs compared to autogenous bone. BM-MSCs have also been used in bone distractions in animal models [23].…”

Section: The Use Of Selected Sc Fractions In Plastic and Reconstructimentioning

confidence: 99%

The Use of Stem Cells in Plastic and Reconstructive Surgery

Koźlik

Wójcicki

2014

Adv Clin Exp Med

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As part of their clinical practice, plastic surgeons perform procedures in the fields of skin and adipose tissue grafting, the reconstruction of compound tissue loss and congenital malformations, the treatment of acute and chronic wounds and burns, as well as cosmetic surgery. On account of the great expectations associated with their use in therapy, stem cells (SCs) are increasingly frequently employed in in vitro experiments, animal models and clinical trials. The most commonly utilized SCs for these purposes are adult stem cells (AS), which are present in small amounts in every tissue; among these are two types of cells: bone marrow mesenchymal stem cells (BM-MSCs) and adipose-derived stem cells (ADSCs). The aim of this review is to present current findings in experimental research on the use of stem cells in the field of plastic and reconstructive surgery. Many studies have described the progress of trials using ADSCs and BM-MSCs mainly in the treatment of compound tissue loss and chronic wounds. The use of their paracrine, proangiogenic and osteogenic functions is emphasized. However, because of the very high harvesting and culturing expenses and the limited availability of data on their safety for human use, SCs are not a first-choice therapy. Further developments in SC research and gradually decreasing costs mean that along with commercial-scale SC culturing, the use of SCs will become a viable alternative to traditional surgical procedures (Adv Clin Exp Med 2014, 23, 6, 1011-1017).

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Section: The Use Of Selected Sc Fractions In Plastic and Reconstructimentioning

confidence: 99%

The Use of Stem Cells in Plastic and Reconstructive Surgery

Koźlik

Wójcicki

2014

Adv Clin Exp Med

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“…The sample size was guided by our previous experiments in which this model was used and by literature reports (Compston et al 1986;Stockmann et al 2012;Jensen et al). The same power, significance level, and expected effect size as in Paper 1 were applied.…”

Section: Papermentioning

confidence: 99%

“…The observation time of 5 weeks was also chosen based on the results of a previous longitudinal study in which this animal model was used (Stockmann et al 2012). …”

Section: Observation Timementioning

confidence: 99%

The effect of erythropoietin on bone

Rölfing¹

2014

Acta Orthopaedica

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“…These studies from in vitro experiments and animal models have questioned the ability of aMSCs for regenerative orthopaedics. Nevertheless, other work has shown equal or superior osteogenesis from aMSCs when compared with bmMSCs [32,36,38]. Although this debate remains unclear it will be critical to evaluate candidate stem cells from the specific patient population to be treated.…”

Section: Discussionmentioning

confidence: 99%

Adipose-derived Mesenchymal Stem Cells Are Phenotypically Superior for Regeneration in the Setting of Osteonecrosis of the Femoral Head

Wyles

Houdek

Crespo‐Diaz

et al. 2015

Clin Orthop Relat Res

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Background Bone marrow-derived mesenchymal stem cells (bmMSCs) have been used as a cellular therapeutic option for treatment of osteonecrosis of the femoral head. However, use of bmMSCs as a treatment adjuvant for orthopaedic disorders in general has achieved limited success. Adipose-derived MSCs (aMSCs) may be a moreefficient regenerative cell source given their greater quantity and protection from physiologic stress.

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Guided bone regeneration in pig calvarial bone defects using autologous mesenchymal stem/progenitor cells – A comparison of different tissue sources

Cited by 118 publications

References 38 publications

The Use of Stem Cells in Plastic and Reconstructive Surgery

The Use of Stem Cells in Plastic and Reconstructive Surgery

The effect of erythropoietin on bone

Adipose-derived Mesenchymal Stem Cells Are Phenotypically Superior for Regeneration in the Setting of Osteonecrosis of the Femoral Head

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