Guided Bone Regeneration in the Edentulous Atrophic Maxilla Using Deproteinized Bovine Bone Mineral (DBBM) Combined with Platelet-Rich Fibrin (PRF)—A Prospective Study

Abstract

Background: Bone regeneration procedures represent a major challenge in oral surgery. This study aimed to evaluate a composite PRF/particulate xenograft in guided bone regeneration. Methods: Edentulous patients with horizontal ridge deficiencies in the anterior maxilla and candidates to an immediate-loading full-arch rehabilitation were included. Horizontal linear measurements indicating bone gain were assessed from computer beam computer tomography (CBCT) scans obtained at pre-surgery, post-surgery, and the 12-month follow-up. Mean bone values were presented as mean ± 95% CI. Non-parametric tests were used as appropriate, and the effect size was calculated with Cohen’s d repeated measures. Results: Eighteen patients were rehabilitated with 72 implants. The mean horizontal bone width was 4.47 [4.13–4.80] mm pre-surgically, 9.25 [8.76–9.75] mm post-surgically, and 7.71 [7.28–8.14] mm 12 months after. Conclusions: PRF associated with a xenograft seems to promote an effective horizontal bone gain. Randomized clinical trials are needed to confirm the benefits of this surgical approach.

Platelet-rich fibrin as an autologous biomaterial for bone regeneration: mechanisms, applications, optimization

“…In another study, PRF was mixed with deproteinized bovine bone mineral (DBBM) and applied to bone augmentation in the severely atrophic alveolar ridge of the maxillary edentulous anterior region. After 1 year, the survival rate of the implants was 98.61%, while the average alveolar bone width was 4.47 mm before the surgery, 9.25 mm right after the surgery, and 7.71 mm 1 year later ( Carames et al, 2022 ). In a study conducted by Gözde Işık et al, they utilized bovine-derived allografts in combination with or without i-PRF for GBR during simultaneous implant placement.…”

Simultaneous Implant and Guided Bone Regeneration Using Bovine-Derived Xenograft and Acellular Dermal Matrix in Aesthetic Zone

“…The clinical manifestation of GBR faces distinct challenges, notably in regions exhibiting vertical bone damage, with volume reductions ranging from 11% to 22% within six months post-tooth loss. Addressing these challenges is paramount for the successful implementation of GBR across diverse clinical contexts, underlining its pivotal role in contemporary dental practices [ 2 , 3 ].…”

“…When combined with autogenous bone or growth factors, these materials serve as a framework, facilitating the adhesion and proliferation of osteoprogenitor cells. This comprehensive understanding of grafting materials and techniques is crucial for optimizing outcomes in bone augmentation procedures [ 2 , 5 ].…”

Application of Fibrin Associated with Photobiomodulation as a Promising Strategy to Improve Regeneration in Tissue Engineering: A Systematic Review

“…The three-dimensional structure of fibrin allows for a series of cellular interactions and provides a temporary matrix in which cells can proliferate, organize, and perform their functions, especially at injured or inflamed sites. Thus, fibrin has been used with the aim of accelerating healing and regeneration in several surgical procedures, especially in medicine in the areas of orthopedics [ 5 , 6 ], neurology [ 7 , 8 , 9 ], and plastic surgery [ 10 , 11 ], as well as in dentistry in the areas of periodontics [ 12 , 13 ], implantology [ 14 , 15 ], and oral and maxillofacial surgery [ 16 , 17 ].…”