Guided bone regeneration membrane made of polycaprolactone/calcium carbonate composite nano-fibers

Fujihara, K.; Kotaki, Masaya; Ramakrishna, Seeram

doi:10.1016/j.biomaterials.2004.09.014

Cited by 563 publications

(356 citation statements)

References 42 publications

Supporting

Mentioning

327

Contrasting

Unclassified

Order By: Relevance

“…Calcium was deposited according to cell orientation on PCL fibers. This observation is in agreement with previously published studies where random and aligned PCL nanofibers have been shown to promote osteogenesis 10, 11, 12, 22. Furthermore, MSC cultured on TCP have been shown to undergo osteogenic differentiation when cultured in osteogenic medium 40.…”

Section: Discussionsupporting

confidence: 93%

“…Bone matrix forms a nanometer‐sized composite of organic and inorganic materials with proteins in the range of 50–500 nm 30, 31. Electrospinning has been widely used to fabricate nanoscale substrates 10, 11, 12, 17, 18, 22, 28. Here, hBMSC orientation and morphology followed the orientation of aligned and random PCL nanofibers.…”

Section: Discussionmentioning

confidence: 99%

“…Due to its cost‐effectiveness and versatility electrospinning has been utilized for the fabrication of fibrous scaffolds with diameters between nanometers to several micrometers 6. Commonly used materials for electrospinning are poly (ɛ‐caprolactone) (PCL) and PCL‐composites, which are attractive for bone tissue regeneration due to their mechanical properties, slow degradation rate, low cost and lack of toxicity 10, 11, 12. Due to their dimension and fibrous structure electrospun nanofibers resemble the native bone matrix and are thought to be an ideal artificial matrix to provide cues for the formation of calcified bone tissue 13, 14.…”

Section: Introductionmentioning

confidence: 99%

“…Bone marrow stromal cells and osteoblast‐like cells exhibited higher proliferation and differentiation as well as an increased alkaline phosphatase (ALP) production on sub‐micrometer sized fibers compared with micrometer‐scaled fiber meshes 10, 11, 16…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Hydrostatic pressure in combination with topographical cues affects the fate of bone marrow‐derived human mesenchymal stem cells for bone tissue regeneration

Reinwald

Haj

2017

J Biomedical Materials Res

View full text Add to dashboard Cite

Topographical and mechanical cues are vital for cell fate, tissue development in vivo, and to mimic the native cell growth environment in vitro. To date, the combinatory effect of mechanical and topographical cues as not been thoroughly investigated. This study investigates the effect of PCL nanofiber alignment and hydrostatic pressure on stem cell differentiation for bone tissue regeneration. Bone marrow‐derived human mesenchymal stem cells were seeded onto standard tissue culture plastic and electrospun random and aligned nanofibers. These substrates were either cultured statically or subjected to intermittent hydrostatic pressure at 270 kPa, 1 Hz for 60 min daily over 21 days in osteogenic medium. Data revealed higher cell metabolic activities for all mechanically stimulated cell culture formats compared with non‐stimulated controls; and random fibers compared with aligned fibers. Fiber orientation influenced cell morphology and patterns of calcium deposition. Significant up‐regulation of Collagen‐I, ALP, and Runx‐2 were observed for random and aligned fibers following mechanical stimulation; highest levels of osteogenic markers were expressed when hydrostatic pressure was applied to random fibers. These results indicate that fiber alignment and hydrostatic pressure direct stem cell fate and are important stimulus for tissue regeneration. © 2017 The Authors Journal of Biomedical Materials Research Part A Published by Wiley Periodicals, Inc. J Biomed Mater Res Part A: A: 629–640, 2018.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hydrostatic pressure in combination with topographical cues affects the fate of bone marrow‐derived human mesenchymal stem cells for bone tissue regeneration

Reinwald

Haj

2017

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…Compared to other polyester family members such as PLA, PGA, and PLGA, PCL has been used less frequently as a material for fabricating biomaterial scaffolds, mainly because of concern over its slower degradation kinetics [136]. However, the improved resistance to hydrolytic attack and lower cost than other biodegradable polymers also make PCL an attractive polymer for the fabrication of electrospun nanofibers [53,77,99,100,[137][138][139][140][141][142][143][144][145][146]. The rationale for using a biodegradable polymer with a longer half-life is to provide a structurally stable environment that is able to initiate and promote cell growth for a sufficient period of time.…”

Section: Synthetic Polymeric Nanofibrous Scaffoldsmentioning

confidence: 99%

Electrospinning Technology for Nanofibrous Scaffolds in Tissue Engineering

Li¹,

Shanti²,

Tuan³

2003

Nanotechnologies for the Life Sciences

View full text Add to dashboard Cite

The sections in this article are Introduction Nanofibrous Scaffolds Fabrication Methods for Nanofibrous Scaffolds Phase Separation Self‐assembly Electrospinning The Electrospinning Process History Setup Mechanism and Working Parameters Properties of Electrospun Nanofibrous Scaffolds Architecture Porosity Mechanical Properties Current Development of Electrospun Nanofibrous Scaffolds in Tissue Engineering Evidence Supporting the Use of Nanofibrous Scaffolds in Tissue Engineering Nanofibrous Scaffolds Enhance Adsorption of Cell Adhesion Molecules Nanofibrous Scaffolds Induce Favorable Cell– ECM Interaction Nanofibrous Scaffolds Maintain Cell Phenotype Nanofibrous Scaffolds Support Differentiation of Stem Cells Nanofibrous Scaffolds Promote in vivo ‐like 3 D Matrix Adhesion and Activate Cell Signaling Pathway Biomaterials Electrospun into Nanofibrous Scaffolds Natural Polymeric Nanofibrous Scaffolds Synthetic Polymeric Nanofibrous Scaffolds Composite Polymeric Nanofibrous Scaffolds Nanofibrous Scaffolds Coated with Bioactive Molecules Engineered Tissues using Electrospun Nanofibrous Scaffolds Skin Blood Vessel Cartilage Bone Muscle Ligament Nerve Current Challenges and Future Directions Conclusion

show abstract

Biomedical Applications of Nanotechnology

Labhasetwar¹,

Leslie‐Pelecky²

2007

View full text Add to dashboard Cite

The ability to investigate substances at the molecular level has boosted the search for materials with outstanding properties for use in medicine. The application of these novel materials has generated the new research field of nanobiotechnology, which plays a central role in disease diagnosis, drug design and delivery, and implants. In this review, we provide an overview of the use of metallic and metal oxide nanoparticles, carbon-nanotubes, liposomes, and nanopatterned flat surfaces for specific biomedical applications. The chemical and physical properties of the surface of these materials allow their use in diagnosis, biosensing and bioimaging devices, drug delivery systems, and bone substitute implants. The toxicology of these particles is also discussed in the light of a new field referred to as nanotoxicology that studies the surface effects emerging from nanostructured materials.

show abstract

Guided bone regeneration membrane made of polycaprolactone/calcium carbonate composite nano-fibers

Cited by 563 publications

References 42 publications

Hydrostatic pressure in combination with topographical cues affects the fate of bone marrow‐derived human mesenchymal stem cells for bone tissue regeneration

Hydrostatic pressure in combination with topographical cues affects the fate of bone marrow‐derived human mesenchymal stem cells for bone tissue regeneration

Electrospinning Technology for Nanofibrous Scaffolds in Tissue Engineering

Biomedical Applications of Nanotechnology

Contact Info

Product

Resources

About