Guided bone regeneration simultaneous with implant placement using bovine-derived xenograft with and without liquid platelet-rich fibrin: a randomized controlled clinical trial

Işık, Gözde; Yüce, Meltem Özden; TOPBAS, Nazan KOCAK; Günbay, Tayfun

doi:10.1007/s00784-021-03987-5

Cited by 24 publications

(26 citation statements)

References 51 publications

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“…Year of publication ranged from 2010 to 2021. Overall, nine studies 10 , 12 , 40 , 41 , 42 , 43 , 44 , 45 , 46 were included and all were designed as parallel‐arm RCTs (Table 2 ). All the studies were performed in university settings with no predominant geographical location.…”

Section: Resultsmentioning

confidence: 99%

“…The most frequent method of assessment was three‐dimensional radiographic methods, including computed tomography and CBCT ( n = 5). 12 , 40 , 41 , 44 , 46 Clinical assessments using a caliper were performed in two studies 10 , 42 and only in two studies histomorphometric assessments were performed. 10 , 43 PROMs was assessed in one study.…”

Section: Resultsmentioning

confidence: 99%

“…Overall, seven studies 10 , 40 , 41 , 42 , 43 , 45 , 46 explored the effects of biologics on horizontal ridge augmentation (HRA), while two studies 12 , 44 evaluated HRA and vertical ridge augmentation (VRA). In three studies, 10 , 41 , 45 conventional guided bone regeneration (GBR) by means of an absorbable barrier membrane was performed in the test and control groups. In one study, GBR was only applied in the test group, while the control group consisted of autogenous block grafts harvested from the mandibular ramus.…”

Section: Resultsmentioning

confidence: 99%

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Efficacy of biologics for alveolar ridge preservation/reconstruction and implant site development: An American Academy of Periodontology best evidence systematic review

Amo¹,

Monje

2022

Journal of Periodontology

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Background: The use of biologics may be indicated for alveolar ridge preservation (ARP) and reconstruction (ARR), and implant site development (ISD). The present systematic review aimed to analyze the effect of autologous bloodderived products (ABPs), enamel matrix derivative (EMD), recombinant human platelet-derived growth factor-BB (rhPDGF-BB), and recombinant human bone morphogenetic protein-2 (rhBMP-2), on the outcomes of ARP/ARR and ISD therapy (i.e., alveolar ridge augmentation [ARA] and maxillary sinus floor augmentation [MSFA]). Methods: An electronic search for eligible articles published from January 2000 to October 2021 was conducted. Randomized clinical trials evaluating the efficacy of ABPs, EMD, rhBMP-2, and rhPDGF-BB for ARP/ARR and ISD were included according to pre-established eligibility criteria. Data on linear and volumetric dimensional changes, histomorphometric findings, and a variety of secondary outcomes (i.e., clinical, implant-related, digital imaging, safety, and patientreported outcome measures [PROMs]) were extracted and critically analyzed. Risk of bias assessment of the selected investigations was also conducted. Results: A total of 39 articles were included and analyzed qualitatively. Due to the high level of heterogeneity across studies, quantitative analyses were not feasible. Most studies in the topic of ARP/ARR revealed that the use of biologics rendered similar results compared with conventional protocols. However, when juxtaposed to unassisted healing or socket filling using collagen sponges, the application of biologics did contribute to attenuate post-extraction alveolar ridge atrophy in most investigations. Additionally, histomorphometric outcomes were positively influenced by the application of biologics. The use of biologics in ARA Both authors contributed equally to this study.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Efficacy of biologics for alveolar ridge preservation/reconstruction and implant site development: An American Academy of Periodontology best evidence systematic review

Amo¹,

Monje

2022

Journal of Periodontology

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“…Through the combined effects of surface resorption and loss of bundle bone following tooth loss causes a noticeable shift in alveolar bone and results in a predictable dimensional alteration. [10] Therefore, an attempt to restore the bone resorbed is required when aiming to resort dentition using implants. [11] Low-speed centrifugation concept was introduced to increase cellular content and growth factor release, which results in liquid PRF.…”

Section: Prf In Gbrmentioning

confidence: 99%

“…An investigation was conducted to assess how augmentation change ridge dimension using liquid PRF with simultaneous implant installation. [10] Control group was bovine bone alone while test group was bovine bone-liquid PRF. At 6 months postoperative, tested group had a slightly greater increase in augmentation than control group.…”

Section: Prf In Gbrmentioning

confidence: 99%

Evaluating the Benefits of Platelet Rich-Fibrin in Periodontal Regeneration: A Literature Review

Albahar¹,

Abu-Ta’a²

2023

OJST

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Introduction: Platelet Rich-Fibrin (PRF) is a biological matrix derived from a patient's own blood, rich in growth factors and platelets. Its use in various periodontal and non-periodontal procedures is gaining recognition due to its potential in promoting tissue regeneration. The purpose of this review was to evaluate the benefits of using PRF in intra-bony defect regeneration, guided-bone regeneration, and sinus floor elevation. Methods: The study searched PubMed for manuscripts published between 2017 and 2022 to better understand the clinical and radiological effects of PRF. The manuscripts were divided into the following sections: intra-bony defect regeneration, guided-bone regeneration, and sinus floor elevation. Results: In intra-bony defects, PRF improved clinical and radiological parameters when compared with OFD alone, with a significant difference in wound healing at 7 days. In GBR, a CBCT evaluation shows no statistical difference between the PRF-autogenous bone complex group and the bovine bone-collagen membrane complex regarding volume change of the augmented bone with a 16% rate of bone loss following a 6-month healing period. Also, a slight increase in bone thickness has been seen when liquid PRF is used. In sinus floor elevation, results revealed no differences in graft volume between PRF group and control group at any of the evaluated time points. Although higher implant stability immediately postoperatively, higher new bone formation, the lesser amount of residual graft and earlier implant placement. Conclusion: Platelet Rich-Fibrin is widely accepted for use in periodontal surgery and dentistry due to its minimally invasive nature and low risk of adverse effects, with positive results in tissue regeneration. There is evidence that PRF leads to improved and faster healing, as well as cost-effective regenerative procedures compared to other treatments.

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Complication rates of guided bone regeneration using titanium-reinforced PTFE membranes: a retrospective analysis

Zeller,

Schenk,

Bonsmann

et al. 2024

Clin Oral Invest

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Guided bone regeneration simultaneous with implant placement using bovine-derived xenograft with and without liquid platelet-rich fibrin: a randomized controlled clinical trial

Cited by 24 publications

References 51 publications

Efficacy of biologics for alveolar ridge preservation/reconstruction and implant site development: An American Academy of Periodontology best evidence systematic review

Efficacy of biologics for alveolar ridge preservation/reconstruction and implant site development: An American Academy of Periodontology best evidence systematic review

Evaluating the Benefits of Platelet Rich-Fibrin in Periodontal Regeneration: A Literature Review

Complication rates of guided bone regeneration using titanium-reinforced PTFE membranes: a retrospective analysis

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