Guided bone regeneration with Pericardium membranes

Gupta, Swati; Gupta, Richa

doi:10.9790/0853-131156165

Cited by 6 publications

(5 citation statements)

References 21 publications

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“…Using biologically safe and natural compounds are effective, especially when they have low cost and better toleration by patients [9]. Several surgical techniques have been used in skin wound healing including dressings, and most of these techniques depending on the bioproducts derived from animal sources (xenografts) (for example, dermal tissue, intestinal submucosa, pericardial, and amniotic membranes) [10-13]. The serum contains a group of proteins that do not involve blood clotting electrolytes, hormones, and antibodies that have antimicrobial and anti-inflammatory activities [8].…”

Section: Introductionmentioning

confidence: 99%

Histological assessment of the efficiency of rabbit serum in healing skin wounds

Majeed

Abood

2019

Vet World

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Aim:This study aimed to investigate the impact of rabbit serum on skin wound healing with the help of histological examination.Materials and Methods:A total of ten indigenous rabbits were used in this study. The animals were divided into two groups: control and serum- treated. The histological assessment was done with a paraffin embedding technique and the histological sections were stained with H&E stain.Results:Severe infiltration of polymorphonuclear leukocytes with severe fibrin deposits were seen in serum treated group at 2 days post-injury; at 7 days post-injury the changes revealed moderate fibroplasia, fibrin deposit and severe infiltration of both mononuclear and polymorphonuclear leukocytes; at 14 days post-injury, there were marked epithelization and dermal deposition of collagen fibers; and at 21 days post-injury, the epidermis completed epithelization and the dermis showed neither fibroplasia nor infiltration of mononuclear and polymorphonuclear leukocytes.Conclusion:The results indicated that rabbit’s serum can prevent wound infection, accelerate epithelialization and cutaneous regeneration with less granulation.

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Section: Introductionmentioning

confidence: 99%

Histological assessment of the efficiency of rabbit serum in healing skin wounds

Majeed

Abood

2019

Vet World

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“…Human gene therapy involves modifying or manipulating the expression of a gene to alter the biological properties of cells. Genetic modification of cells can be used to control periodontal diseases and help to reconstruct damaged periodontal apparatus in periodontal tissue engineering [ 59 , 60 ]. Gene-based therapeutics would carry a gene into progenitor tissues, signaling them to differentiate into a phenotype favoring regeneration and repair, transforming a defect [ 61 ].…”

Section: Gene Therapymentioning

confidence: 99%

Future Drug Targets in Periodontal Personalised Medicine—A Narrative Review

Yadalam

Varatharajan

Fageeh

et al. 2022

JPM

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Periodontal disease is an infection-driven inflammatory disease characterized by the destruction of tooth-supporting tissues. The establishment of chronic inflammation will result in progressive destruction of bone and soft tissue changes. Severe periodontitis can lead to tooth loss. The disease has complex pathogenesis with an interplay between genetic, environmental, and host factors and pathogens. Effective management consists of plaque control and non-surgical interventions, along with adjuvant strategies to control inflammation and disrupt the pathogenic subgingival biofilms. Recent studies have examined novel approaches for managing periodontal diseases such as modulating microbial signaling mechanisms, tissue engineering, and molecular targeting of host inflammatory substances. Mounting evidence suggests the need to integrate omics-based approaches with traditional therapy to address the disease. This article discusses the various evolving and future drug targets, including proteomics, gene therapeutics, vaccines, and nanotechnology in personalized periodontal medicine for the effective management of periodontal diseases.

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“…Este é um tecido de natureza elástica, tornando-o de fácil manuseio e ideal para ser aplicado em GBR, de forma a impedir a invasão de tecidos não-osteogénicos competitivos na zona do defeito ósseo (Maurer, T. et al, 2018;Bai, M. et al, 2014). A biocompatibilidade destes materiais xenógenos está, no entanto, dependente da sua purificação, pelo que vários protocolos têm vindo a ser desenvolvidos nesse âmbito, de forma a manter apenas a estrutra tridimensional e a ECM acelular do pericárdio (Gupta, S. & Gupta, D., 2014;Gardin, C. et al, 2015). A fixação destas membranas com glutaraldeído após a purificação já demonstrou vantagens adicionais, como otimização das suas propriedades mecânicas, sem apresentar citotoxicidade.…”

Section: Membranas Xenógenas Para Reparo óSseounclassified

Biomateriais sintéticos e xenógenos com alto potencial clínico para reparo tecidual

Souza¹,

Carvalho

Henriques

et al. 2019

RevSALUS

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O objetivo do presente trabalho foi realizar uma revisão da literatura sobre o uso de biomateriais de origem animal (xenógeno) e sintética para o reparo do tecidual. Diferentes materiais cerâmicos e poliméricos sintéticos e xenógenos são aplicados para o reparo ósseo. Dentre os cerâmicos, a mistura de hidroxiapatite e ?-TCP (60-70/40-30 wt%), apatite carbonada e hidroxiapatite de origem bovina ou suína são comumente aplicados, no entanto a taxa de absorção dos materiais sintéticos é lenta quando comparado ao processo de cicatrização na presença dos xenógenos. Além disso, a resposta biológica de materiais sintéticos ainda é inferior à resposta aos materiais xenógenos. Tendo em consideração os diversos polímeros, os materiais xenógenos (ex. colagénio, quitosana) têm apresentado uma resposta biológica mais adequada quando comparado aos sintéticos (ex. PLGA, PLDLA). A cicatrização tecidual óssea é um processo que envolve fases de migração celular, deposição de proteínas e minerais, formação vascular, e desenvolvimento de tecidos conectivo e ósseo. O desenvolvimento de polímeros sintéticos com taxa de absorção adequada ao processo de reparo tecidual associada a uma alta bioatividade e promoção da angiogénese tem sido o alvo de estudos recentes. Além disso, combinação de sintéticos e xenógenos também torna-se uma alternativa com alto potencial de sucesso clínico.

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Guided bone regeneration with Pericardium membranes

Cited by 6 publications

References 21 publications

Histological assessment of the efficiency of rabbit serum in healing skin wounds

Histological assessment of the efficiency of rabbit serum in healing skin wounds

Future Drug Targets in Periodontal Personalised Medicine—A Narrative Review

Biomateriais sintéticos e xenógenos com alto potencial clínico para reparo tecidual

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