“…According to several authors, the SG approach offers a highly predictable alternative to access the root canals in comparison to freehand drilling in challenging cases (Ali & Arslan, 2021;Buchgreitz et al, 2016Buchgreitz et al, , 2019aBuchgreitz et al, , 2019bByun et al, 2015;Casadei et al, 2020;Connert et al, 2017Connert et al, , 2018Connert et al, , 2019Kostunov et al, 2021;Krastl et al, 2016;Krug et al, 2020;Lara-Mendes et al, 2018aLlaquet Pujol et al, 2021;Loureiro et al, 2020;Maia et al, 2019;Shi et al, 2018; Tchorz et al, 2019;Todd et al, 2021;Torres et al, 2019Torres et al, , 2021bZehnder et al, 2016). However, the application of SG for endodontic access may be burdened with multiple sources of errors during the workflow because of an inadequate intraoral scan or impression, CBCT artefacts, human error during the design leading to poor alignment during meshing of digital and CBCT renderings, and inconsistency in resin thickness during 3D printing, which ultimately may cause instability of the guide (Jain et al, 2020b) (Table 2).…”