Guided Inquiry in Sophomore Organic Lecture: Deducing Mechanisms by Reaction Mapping

Taber, Douglass F.

doi:10.26434/chemrxiv-2021-zg1d4

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…Another activity that falls outside the general course structure is spending one class (Weeks 6–9, Table ) on solving complicated rearrangement mechanisms using bonds broken/bonds formed mapping. , Relating strategies the students used to solve complex mechanisms in sophomore organic chemistry to the transformations in advanced organic chemistry allows for solving mechanisms not located in the literature. For example, the mechanism of an acid-catalyzed rearrangement is often not discussed in an article, and as that rearrangement is often unique to the molecule being synthesized, it is often difficult to find a helpful reference specific to the mechanism in question.…”

Section: Additional Class Activities Other Than Those In the General ...mentioning

confidence: 99%

To the Literature and Beyond: Teaching Advanced Organic Chemistry at a Primarily Undergraduate Institution

2022

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Offering an advanced organic chemistry course at a primarily undergraduate institution poses a challenge of condensing graduate organic synthesis into one course. This course was designed so students choose and read recent total synthesis papers from the literature in lieu of relying on a textbook or other preexisting course materials. Following the reading, students are required to propose a reasonable arrow-pushing mechanism for each step in the paper. The professor guides students on how to develop the ability to use resources (e.g., the primary literature, books, search engines, etc.) to propose mechanisms for reactions that are new to the students. In-class group work is implemented to promote active learning of complex topics. All mechanism proposals are presented to the entire class so that students become competent at communicating complex topics to others. Students not only learn many new reagents, reactions, and mechanisms relevant to modern organic synthesis but more importantly become proficient in finding detailed information on unfamiliar topics, a skill valuable to any scholar. As the course does not require the creation of materials such as problem sets or lecture notes, it can be taught with minimal preparation and work during the week by an instructor holding a PhD in synthetic organic chemistry or a closely related field.

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Section: Additional Class Activities Other Than Those In the General ...mentioning

confidence: 99%

To the Literature and Beyond: Teaching Advanced Organic Chemistry at a Primarily Undergraduate Institution

2022

View full text Add to dashboard Cite

show abstract

Guided Inquiry in Sophomore Organic Lecture: Deducing Mechanisms by Reaction Mapping

Cited by 1 publication

References 17 publications

To the Literature and Beyond: Teaching Advanced Organic Chemistry at a Primarily Undergraduate Institution

To the Literature and Beyond: Teaching Advanced Organic Chemistry at a Primarily Undergraduate Institution

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