Guided mode resonances and photonic crystals for biosensing and imaging

Drayton, Alexander; Barth, Isabel; Krauss, Thomas F.

doi:10.1016/bs.semsem.2019.01.002

Cited by 8 publications

(6 citation statements)

References 54 publications

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“…This results in a surface functionalized with a monolayer of NHS esters which can form a covalent bond with free amines exposed on the antibody surface. We also note that the physical thickness of the SM(PEG)6 monolayer is < 3 nm, which is much shorter than the evanescent tail of the GMR mode of >100 nm (Drayton et al, 2019). We thus do not expect the SM(PEG)6 spacer to adversely affect the sensitivity of the GMR.…”

Section: Introductionmentioning

confidence: 76%

Guided mode resonance sensor for the parallel detection of multiple protein biomarkers in human urine with high sensitivity

Kenaan

Barth

et al. 2020

Biosensors and Bioelectronics

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The rising cost of global healthcare provision and new approaches to managing disease are driving the development of low-cost biosensing modalities, such as label-free photonic methods based on dielectric resonances. Here, we use the combined sensing and imaging capability of a guided mode resonance (GMR) sensor to detect multiple biomarkers (troponin, procalcitonin and C-Reactive Protein) in parallel in undiluted urine samples. A key requirement of such a biosensor is the simple and direct functionalization with suitable antibodies to ensure the disease-specific detection of protein biomarkers. Here, antibodies were immobilized using a succinimidyl-[(Nmaleimidopropionamido)-hexaethyleneglycol] ester (SM(PEG)6) spacer. The polyethylene glycol (PEG) chemistry enables low detection limits of 10 pg mL -1 or better for all protein biomarkers, while minimizing non-specific binding compared to more commonly used strategies such as (3-Aminopropyl)triethoxysilane (APTES) or dextran. Our approach supports the vision of a simple yet highly sensitive diagnostic platform that could be used for pre-screening patients for a wide range of diseases at point-of-care, thereby relieving the pressure on overstretched healthcare services.

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Section: Introductionmentioning

confidence: 76%

Guided mode resonance sensor for the parallel detection of multiple protein biomarkers in human urine with high sensitivity

Kenaan

Barth

et al. 2020

Biosensors and Bioelectronics

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“…This approach avoids the need to pass light through the bulk of the liquid, as operation in transmission would require, ensuring that the coherent light does not accumulate phase noise due to turbulence introduced by the microfluidic system. With these boundary conditions, a common-path interferometric approach can exploit the fact that these dielectric nanostructures support two modes of orthogonal polarization with different phase sensitivities 19 . We refer to the mode with the dominant electric field oriented along the grating grooves (y direction, Fig.…”

Section: Phase-sensitive Detection Principlementioning

confidence: 99%

Common-path interferometric label-free protein sensing with resonant dielectric nanostructures

et al. 2020

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Research toward photonic biosensors for point-of-care applications and personalized medicine is driven by the need for high-sensitivity, low-cost, and reliable technology. Among the most sensitive modalities, interferometry offers particularly high performance, but typically lacks the required operational simplicity and robustness. Here, we introduce a common-path interferometric sensor based on guided-mode resonances to combine high performance with inherent stability. The sensor exploits the simultaneous excitation of two orthogonally polarized modes, and detects the relative phase change caused by biomolecular binding on the sensor surface. The wide dynamic range of the sensor, which is essential for fabrication and angle tolerance, as well as versatility, is controlled by integrating multiple, tuned structures in the field of view. This approach circumvents the trade-off between sensitivity and dynamic range, typical of other phase-sensitive modalities, without increasing complexity. Our sensor enables the challenging label-free detection of procalcitonin, a small protein (13 kDa) and biomarker for infection, at the clinically relevant concentration of 1 pg mL −1 , with a signal-to-noise ratio of 35. This result indicates the utility for an exemplary application in antibiotic guidance, and opens possibilities for detecting further clinically or environmentally relevant small molecules with an intrinsically simple and robust sensing modality.

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“…Types of the Periodical Structure. When designing a GMR device, one of the simplest diffractive elements to select is one-dimensional grating 25 as shown in the left side in Figure 1g. The refractive index profile changes periodically along one direction, the x-axis in the figure.…”

Section: Introductionmentioning

confidence: 99%

Polymer-Based Guided-Mode Resonance Sensors: From Optical Theories to Sensing Applications

Fallah,

Hakim,

Boonruang

et al. 2023

ACS Appl. Polym. Mater.

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Guided mode resonances and photonic crystals for biosensing and imaging

Cited by 8 publications

References 54 publications

Guided mode resonance sensor for the parallel detection of multiple protein biomarkers in human urine with high sensitivity

Guided mode resonance sensor for the parallel detection of multiple protein biomarkers in human urine with high sensitivity

Common-path interferometric label-free protein sensing with resonant dielectric nanostructures

Polymer-Based Guided-Mode Resonance Sensors: From Optical Theories to Sensing Applications

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