Guided Tissue Regeneration: A Review

Jacob, Smitha Annie; Amudha, D.

doi:10.15406/jdhodt.2017.06.00197

Cited by 10 publications

(5 citation statements)

References 25 publications

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“…Several techniques such as the free gingival graft (FGG), laterally or coronally positioned flaps (CAF), subepithelial connective tissue graft (SCTG), guided tissue regeneration (GTR) based root coverage procedures have been suggested to resolve the above-mentioned issues. [ 2 ] CAF is recommended surgical technique where there is presence of adequate keratinized gingiva apical to recession defect. The subepithelial connective tissue graft (SCTG) with coronally advanced flap (CAF) is considered as the gold standard technique for root coverage.…”

Section: Introductionmentioning

confidence: 99%

A meta-analysis of amnion membrane in gingival recession

Lubaib

2023

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This systematic review was conducted to evaluate the effects of Amniotic Membrane (AM) as compared with other treatment modalities on the clinical outcomes, in gingival recession defects. Only Randomized controlled clinical trials published before 2020 were included. Studies were divided into 5 subgroups (1) Coronally advanced flap (CAF)+AM v/s Chorion membrane (CM) (2) CAF+AM v/s CAF+PRF (3) CAF+AM v/s CAF+Collagen membrane (4) CAF+AM v/s CAF (5) CAF+AM v/s CAF+ Subepithelial connective tissue graft (SCTG). Studies were evaluated for Recession Depth (RD) (Primary outcome); Clinical Attachment Level (CAL), Recession Width (RW) and Width of Keratinized Gingiva (WKG) (Secondary outcomes). The inverse variance approach was utilised in fixed or random effect models for the meta-analysis, which were chosen based on heterogeneity. Results suggested that the use of AM membrane showed comparable results in improving RD, RW, or CAL in the treatment of Miller Class-I and Class-II gingival recession compared to the other treatment modalities. However, CAF+AM resulted in statistically significant improvement in RD and RW than CAF+SCTG, though CAL gain was statistically more with CAF+SCTG. However, increase of WKG was found to be statistically significantly more in all the other treatment modalities as compared to CAF+AM. With properties like self-adherence, bioavailability and presence of growth factors AM with CAF can produce good aesthetic root coverage comparable to SCTG and PRF, where width of keratinized gingiva is adequate.

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Section: Introductionmentioning

confidence: 99%

A meta-analysis of amnion membrane in gingival recession

Lubaib

2023

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“…To date, enamel matrix derivative (EMD) is considered one of the few biomaterials for clinical use capable of demonstrating true periodontal regeneration. [28][29][30] Amelogenins are a family of highly conserved extracellular matrix proteins derived from a single gene and play a role in biomineralization and hard tissue formation. Amelogenins can have a positive effect on wound healing, bone formation.…”

Section: Introductionmentioning

confidence: 99%

The Application of an Enamel Matrix Protein (Emdogain) In Regenerative Periodontal Therapy. Clinical Series

Melker

2023

JBSMFS

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Objectives: The purpose of this clinical series is to present indications for regenerative therapy with EMD. Materials and Methods: The study included 53 patients with osseous defects from 7-15mm’s in depth. Each patient understood that the procedures were not within the normal treatment due to the severity of the defects but opted to accept treatment. Along with EMD each defect also had freeze fried demineralized bone placed in the defect as well. Results: Reentry of the original defects was undertaken at approximately 1 year after surgery. It was noted that for the most part significant improvement was noted in almost all defects. Exact improvement of defects was not calculated. In several cases 10-year reentry was undertaken and in fact further reduction in defects were noted. It could not be determined at any time over the 10-year period that the reduction in pocket depth was in fact bone as no histology was ever taken to verify what the defects were filled with. Conclusions: Clinical studies have indicated that treatment with EMD with freeze dried demineralized bone positively influences regenerative periodontal therapy.

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“…Thirty percent of the organic materials are mainly composed of collagen fibers and small amount of glycoprotein and proteoglycan [4]. Bone defect is a condition of discontinuity in the structure of bone tissue or cartilage caused by trauma and the bone capable to spontaneously regenerate as before without the formation of scar tissue [5,6]. Data from Riset Kesehatan Dasar (Riskesdas) in 2018 stated that the percentage bone defect cases in Indonesia was 5.5%.…”

Section: Introductionmentioning

confidence: 99%

Chitosan as Bone Scaffold and Graft Materials for Bone Regeneration: A Systematic Review

Wahjuningrum

Setyabudi

Cahyani

et al. 2022

Mal. J. Fund. Appl. Sci.

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Chitosan is a natural biodegradable polymer made from crustacean exoskeletons (shrimp and crab). Recently, natural material is preferably used in order to prevent any side effects from synthetic material. Previous research showed that chitosan has anti-bacterial properties, which can act as a bone graft scaffold material to increase in bone regeneration process. This article discusses the antibacterial effect of chitosan in the bone regeneration process. Bone graft consists of many primary graft materials which focus on alloplastic graft composite type. Bone graft is related to bone regeneration which associated with the process of secondary/indirect bone healing. The main trait of bone graft material is that it is not toxic to the chitosan’s host cell. Chitosan’s anti-bacterial effects can be associated with one of the three phases of bone defect healing, which is inflammation phase that acts to prevent bacterial invasion as an infectious disease in bone injury. Because of this, it can accelerate the polarization of macrophage M1 (secrete pro-inflammatory cytokine) to macrophage M2 (secrete anti-inflammatory cytokine) that relates to osteoblastogenesis. Osteoblastogenesis relates to the increase of osteoblast synthesis, deposition and mineralization of extracellular matrix leading to the maturation of osteoblast become osteocyte called ossification process.

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Guided Tissue Regeneration: A Review

Cited by 10 publications

References 25 publications

A meta-analysis of amnion membrane in gingival recession

A meta-analysis of amnion membrane in gingival recession

The Application of an Enamel Matrix Protein (Emdogain) In Regenerative Periodontal Therapy. Clinical Series

Chitosan as Bone Scaffold and Graft Materials for Bone Regeneration: A Systematic Review

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